Zum Andenken an Niederlahnstein Saarbrücken Portraits Groups

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Albert and Elsa Einstein on the beach with Walter Adams; Santa Barbara, California Portraits; Groups

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Portrait of Moritz and Helene Leffmann Portraits Couples

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Nachum Glatzer studying Torah Portraits Men

Signed by photographer lower right

Henry Rosenbaum seated at a desk smoking a cigar and sketching; New York Portraits Men

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Photographic reproduction of charcoal portrait of Arnold Gottlieb Portraits Men

Signed by artist bottom right

Reproduction of studio portrait of Julie Ehrenberg nee Fischel Portraits Women

Original held by Paul Ehrenberg

Studio portrait of Charlotte (Lotte) Engel Levison; New Jersey Portraits Women

Signed by photographer

Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six large, independent cohort studies with a total of 19 713 participants. The meta-analysis estimate of TL heritability was 0.70 (95% CI 0.64–0.76) and is based on a pattern of results that is highly similar for twins and other family members. We observed a stronger mother–offspring (r=0.42; P-value=3.60 × 10−61) than father–offspring correlation (r=0.33; P-value=7.01 × 10−5), and a significant positive association with paternal age at offspring birth (β=0.005; P-value=7.01 × 10−5). Interestingly, a significant and quite substantial correlation in TL between spouses (r=0.25; P-value=2.82 × 10−30) was seen, which appeared stronger in older spouse pairs (mean age ≥55 years; r=0.31; P-value=4.27 × 10−23) than in younger pairs (mean age<55 years; r=0.20; P-value=3.24 × 10−10). In summary, we find a high and very consistent heritability estimate for TL, evidence for a maternal inheritance component and a positive association with paternal age.

Albert Einstein sailing with Margarete Lebach; Huntington Portraits; Couples

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