Northern Ireland Substitute Prescribing Database Report 31 March 2013

This bulletin summarises information on individuals referred to the Northern Ireland Substitute Prescribing Scheme (SPS). It relates to those referred up to and including the 31 March 2013 and focuses on those patients in contact with Substitute Prescribing treatment services during 2012/13.

Dictionnaire de théologie morale... ; suivi d'un Plan méthodique de la théologie laissé inédit par Bergier et d'après lequel on peut lire avec suite son dictionnaire... : présentant un exposé complet de la morale chrétienne, contenant une règle de conduite pour les principales circonstances de la vie, offrant un complément nécessaire à toutes les éditions du Dictionnaire.... Tome 31 / par M. l'abbé Pierrot,...

Collection : Encyclopédie théologique ...

31 mai 1916, bataille du Jutland : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54226

Bataille du Jutland, 31 mai 1916 : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54225

31 mai 1916, bataille du Jutland, à droite le "Queen Mary", à gauche le "Lion" : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54224

31-5-19, [basilique] Ste Clothilde, mariage du comte François de Vogüé avec Melle Clothilde de Durfort de Civrac de Lorge [Durfort-Civrac de Lorge ?] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54156

Mycobacterium tuberculosis epitope-specific interferon-g production in healthy Brazilians reactive and non-reactive to tuberculin skin test

The interferon (IFN)-γ response to peptides can be a useful diagnostic marker of Mycobacterium tuberculosis (MTB) latent infection. We identified promiscuous and potentially protective CD4+ T-cell epitopes from the most conserved regions of MTB antigenic proteins by scanning the MTB antigenic proteins GroEL2, phosphate-binding protein 1 precursor and 19 kDa antigen with the TEPITOPE algorithm. Seven peptide sequences predicted to bind to multiple human leukocyte antigen (HLA)-DR molecules were synthesised and tested with IFN-γ enzyme-linked immunospot (ELISPOT) assays using peripheral blood mononuclear cells (PBMCs) from 16 Mantoux tuberculin skin test (TST)-positive and 16 TST-negative healthy donors. Eighty-eight percent of TST-positive donors responded to at least one of the peptides, compared to 25% of TST-negative donors. Each individual peptide induced IFN-γ production by PBMCs from at least 31% of the TST-positive donors. The magnitude of the response against all peptides was 182 ± 230 x 106 IFN-γ spot forming cells (SFC) among TST-positive donors and 36 ± 62 x 106 SFC among TST-negative donors (p = 0.007). The response to GroEL2 (463-477) was only observed in the TST-positive group. This combination of novel MTB CD4 T-cell epitopes should be tested in a larger cohort of individuals with latent tuberculosis (TB) to evaluate its potential to diagnose latent TB and it may be included in ELISPOT-based IFN-γ assays to identify individuals with this condition.

Le Shah de Perse à son arrivée à Douvres [31 octobre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56797