Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice

Chronic and excessive alcohol consumption is an established risk for hepatic inflammation and carcinogenesis. Luteolin is one of the most common flavonoids present in plants and has potential beneficial effects against cancer. In this study, we examined the effect and potential mechanisms of luteolin supplementation in a carcinogen initiated alcohol-promoted pre-neoplastic liver lesion mouse model. C57BL/6 mice were injected with diethylnitrosamine (DEN) [i.p. 25 mg/kg of body weight (BW)] at 14 days of age. At 8 weeks of age mice were group pair-fed with Lieber-DeCarli liquid control diet or alcoholic diet [ethanol (EtOH) diet, 27% total energy from ethanol] and supplemented with a dose of 30 mg luteolin/kg BW per day for 21 days. DEN-injected mice fed EtOH diet displayed a significant induction of pre-neoplastic lesions, a marker associated with presence of steatosis and inflammation. Dietary luteolin significantly reduced the severity and incidence of hepatic inflammatory foci and steatosis in DEN-injected mice fed EtOH diet, as well the presence of preneoplastic lesions. There was no difference on hepatic protein levels of sirtuin 1 (SIRT1) among all groups; however, luteolin supplementation significantly reversed alcohol-reduced SIRT1 activity assessed by the ratio of acetylated and total forkhead box protein O1 (FoXO1) and SIRT1 target proliferator-activated receptor gamma, coactivator 1 alpha (PGC1α). Dietary intake of luteolin prevents alcohol promoted pre-neoplastic lesions, potentially mediated by SIRT1 signaling pathway.

Hands-Free Navigation in Immersive Environments for the Evaluation of the Effectiveness of Indoor Navigation Systems

While navigation systems for cars are in widespread use, only recently, indoor navigation systems based on smartphone apps became technically feasible. Hence tools in order to plan and evaluate particular designs of information provision are needed. Since tests in real infrastructures are costly and environmental conditions cannot be held constant, one must resort to virtual infrastructures. This paper presents the development of an environment for the support of the design of indoor navigation systems whose center piece consists in a hands-free navigation method using the Microsoft Kinect in the four-sided Definitely Affordable Virtual Environment (DAVE). Navigation controls using the user's gestures and postures as the input to the controls are designed and implemented. The installation of expensive and bulky hardware like treadmills is avoided while still giving the user a good impression of the distance she has traveled in virtual space. An advantage in comparison to approaches using a head mounted display is that the DAVE allows the users to interact with their smartphone. Thus the effects of different indoor navigation systems can be evaluated already in the planning phase using the resulting system

Reb Jiśroel Bal-Šem-Ṭov : zain leben, lehre un wirken

fun Š. Tz. Zetzer

One-Step Identification of Five Prominent Chicken Salmonella Serovars and Biotypes.

Based on bacterial genomic data, we developed a one-step multiplex PCR assay to identify Salmonella and simultaneously differentiate the two invasive avian-adapted S. enterica serovar Gallinarum biotypes Gallinarum and Pullorum, and the most frequent, specific, and asymptomatic colonizers of chickens, serovars Enteritidis, Heidelberg, and Kentucky.

Debates lingüísticos en la revista Nosotros (1907-1920)

Partiendo de la noción williamsiana de las revistas como lugar de convergencia de tendencias que conviven en el entramado cultural, trataremos de rastrear las distintas concepciones acerca de la lengua que conviven en la revista Nosotros en un corpus que abarca desde su inicio en 1907 hasta 1920. Inicialmente vemos que los debates sobre la identidad nacional, que tocan el tema de la lengua nacional, conviven con cuestiones lingüísticas vinculadas a la gramática y la normativa, a la correcta transcripción al español de lenguas extranjeras, etc. Nuestra propuesta es ahondar en esta convivencia para delinear un panorama de las preocupaciones de índole lingüística que convergen en Nosotros

Debates lingüísticos en la revista Nosotros (1907-1920)

Partiendo de la noción williamsiana de las revistas como lugar de convergencia de tendencias que conviven en el entramado cultural, trataremos de rastrear las distintas concepciones acerca de la lengua que conviven en la revista Nosotros en un corpus que abarca desde su inicio en 1907 hasta 1920. Inicialmente vemos que los debates sobre la identidad nacional, que tocan el tema de la lengua nacional, conviven con cuestiones lingüísticas vinculadas a la gramática y la normativa, a la correcta transcripción al español de lenguas extranjeras, etc. Nuestra propuesta es ahondar en esta convivencia para delinear un panorama de las preocupaciones de índole lingüística que convergen en Nosotros

Debates lingüísticos en la revista Nosotros (1907-1920)

Partiendo de la noción williamsiana de las revistas como lugar de convergencia de tendencias que conviven en el entramado cultural, trataremos de rastrear las distintas concepciones acerca de la lengua que conviven en la revista Nosotros en un corpus que abarca desde su inicio en 1907 hasta 1920. Inicialmente vemos que los debates sobre la identidad nacional, que tocan el tema de la lengua nacional, conviven con cuestiones lingüísticas vinculadas a la gramática y la normativa, a la correcta transcripción al español de lenguas extranjeras, etc. Nuestra propuesta es ahondar en esta convivencia para delinear un panorama de las preocupaciones de índole lingüística que convergen en Nosotros