A phase I study of combined docetaxel and repeated high activity Re-186-HEDP in castration-resistant prostate cancer (CRPC) metastatic to bone (the TAXIUM trial)

Purpose Bone-seeking radiopharmaceuticals have palliative benefit in castration-resistant prostate cancer (CRPC) metastatic to bone. Recent studies have shown improvement of survival and quality of life when radiopharmaceuticals were given repeatedly or in combination with chemotherapy. We designed a phase I study combining docetaxel and Re-186-labelled hydroxyethylidene diphosphonate (HEDP) in men with CRPC and bone metastases to evaluate toxicity.

Resolución No. 186

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Resolución N° 186 ¿Bajo que criterios evalúa la cámara de comercio la toma de decisiones en las sociedades de responsabilidad limitada ?

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Resolución N° 186 ¿Existe la necesidad algún requisito previo para que la cámara de comercio pueda estudiar la inscripción de actos de entidades sometidas a vigilancia de superintendencia financiera?

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Resolución N° 186 del 14 de agosto de 2007 ¿Bajo que criterios evalúa la Cámara de Comercio la toma de decisiones en las sociedades de responsabilidad limitada ?

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HG 186.9-187.0 D.E-1

Coarse grained sediment with a few fine grained matrices. Brown sediment with small to medium sized clasts. Clasts range from sub-angular to sub-rounded. Organic material present.

HG 186.9-187.0 D.E-2

Coarse grained sediment with small patches of a fine grained domain. The domain may contain organic material. Lineations and minor grain stack present throughout the section.

HG 186.9-187.0 D.E-3

Fractured and weathered grains throughout the section. Lineations and grain stacks throughout the section.

HG 186.9-187.0 D.E-4

Fine grained domain within a coarse grained domain. Lineations throughout the section. A few small patches of a clay domain seen towards the top left.

HG 186.15-186.25-1

Coarse grained section with two different fine grained domains. Towards the left hand side the domain is dark and has no inclusions of coarse grains. The right hand side has some coarser materials.

HG 186.15-186.25-2

Major grains crushing towards the top left with two fine grained domains in coarse grained sediment.