Hineh mah-tov u-mah-naʿim : Psalm 133 ; für Männerchor, Harmonium- und Pianoforte-Begleitung

componirt von Ed. Birnbaum

Bundeslied : [nach Psalm 133] ; für israelitische Cantoren

comp. ... von Adolph Schönfeld

Bundeslied : [nach Psalm 133]

comp. von A. Schönfeld

Ms. hebr. oct. 133 - [Sammelband in 6 Teilen: Handschriftenkonvolut]

Vorbesitzer: Abraham Merzbacher

Monitoring and Switching of First-line Antiretroviral Therapy in sub-Saharan Africa: Collaborative Analysis of Adult Treatment Cohorts.

BACKGROUND HIV-1 viral load (VL) testing is recommended to monitor antiretroviral therapy (ART) but not universally available. We examined monitoring of first-line and switching to second-line ART in sub-Saharan Africa, 2004-2013. METHODS Adult HIV-1 infected patients starting combination ART in 16 countries were included. Switching was defined as a change from a non-nucleoside reverse-transcriptase inhibitor (NNRTI)-based regimen to a protease inhibitor (PI)-based regimen, with a change of ≥1 NRTI. Virological and immunological failures were defined per World Health Organization criteria. We calculated cumulative probabilities of switching and hazard ratios with 95% confidence intervals (CI) comparing routine VL monitoring, targeted VL monitoring, CD4 cell monitoring and clinical monitoring, adjusted for programme and individual characteristics. FINDINGS Of 297,825 eligible patients, 10,352 patients (3·5%) switched during 782,412 person-years of follow-up. Compared to CD4 monitoring hazard ratios for switching were 3·15 (95% CI 2·92-3·40) for routine VL, 1·21 (1·13-1·30) for targeted VL and 0·49 (0·43-0·56) for clinical monitoring. Overall 58.0% of patients with confirmed virological and 19·3% of patients with confirmed immunological failure switched within 2 years. Among patients who switched the percentage with evidence of treatment failure based on a single CD4 or VL measurement ranged from 32·1% with clinical to 84.3% with targeted VL monitoring. Median CD4 counts at switching were 215 cells/µl under routine VL monitoring but lower with other monitoring (114-133 cells/µl). INTERPRETATION Overall few patients switched to second-line ART and switching occurred late in the absence of routine viral load monitoring. Switching was more common and occurred earlier with targeted or routine viral load testing.

Neue Beiträge zur Geschichte des Exilarchats : der Nachfolgestreit zwischen David ben Jehuda und Daniel um 825

Felix Lazarus

Ms. Barth. 133 - Medizinische Sammelhandschrift

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 825 - Freude über die bestehende Brieffreundschaft

u.a. aktuelle Ereignisse in Hamburg; Bitte um Mitbringsel aus Frankreich;