My Oxford ABC and 123 : picture, rhyme, book.

Los niños más pequeños utilizando puzzles, chistes, juegos y distintas actividades aprenden las primeras letras y los primeros números. De una forma divertida, se preparan para leer, escribir y trabajar en la escuela. También es aconsejable para ampliar su vocabulario.

Farm 123.

Un primer libro para aprender a contar del uno al diez con los animales de la granja. Levanta las solapas y descubre lo que se esconde debajo de ellas.

Sequential 123-I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and 18-F-FDG-PET imaging)

Purpose Muscarinic acetylcholine receptors (mAChRs) play an important role in the generation of seizures. Single-photon emission computed tomography (SPECT) with ¹²³I-iododexetimide (IDEX) depicts tracer uptake by mAChRs. Our aims were to: (a) determine the optimum time for interictal IDEX SPECT imaging; (b) determine the accuracy of IDEX scans in the localisation of seizure foci when compared with video EEG and MR imaging in patients with temporal lobe epilepsy (TLE); (c) characterise the distribution of IDEX binding in the temporal lobes and (d) compare IDEX SPECT and ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in identifying seizure foci.
Methods We performed sequential scans using IDEX SPECT imaging at 0, 3, 6 and 24 h in 12 consecutive patients with refractory TLE undergoing assessment for epilepsy surgery. Visual and region of interest analyses of the mesial, lateral and polar regions of the temporal lobes were used to compare IDEX SPECT, FDG PET and MR imaging in seizure onset localisation.
Results The 6-h IDEX scan (92%; κappa=0.83, p=0.003) was superior to the 0-h (36%; kappa=0.01, p>0.05), 3-h (55%;κappa=0.13, p>0.05) and 24-h IDEX scans in identifying the temporal lobe of seizure origin. The 6-h IDEX scan correctly predicted the temporal lobe of seizure origin in two patients who required intracranial EEG recordings to define the seizure onset. Reduced ligand binding was most marked at the temporal pole and mesial temporal structures. IDEX SPECT was superior to interictal FDG PET (75%; κappa=0.66, p=0.023) in seizure onset localisation. MR imaging was non-localising in two patients in whom it was normal and in another patient in whom there was bilateral symmetrical hippocampal atrophy.
Conclusion The 6-h IDEX SPECT scan is a viable alternative to FDG PET imaging in seizure onset localisation in TLE.

O uso do poder de compra do estado como instrumento de política pública: a lei complementar nº 123/2006, sua implementação

This study aims to bring back the debate on the use of the purchasing power of the State as instrument to boost other public policies established by federal entities. Besides putting it in a context of innovation in the public sector, the study of this issue must consider all its variables and questions, whwther of legal, economic, social or political order, starting with the one I consider the most important: the possibility of the State to assert its power of puchasing in order to design and promote markets, searching to achieve other objectives rather than those traditionally accepted. Thus, in the analysis of a direct application of a new practice, this study evaluates the implementation of the Additional Law number 123/06, which gives a differentiating treatment to micro and small enterprises in public contracting. By means of interviews, information was collected with the relevant actors in in this phase. The conclusion was that aspects such as the heterogeneity of the segment of the MPE`s and their low capacity of articulation, along with the endogenous obstacles of the instituion of the bidding, contribute decively to the low stage of the implementation that occurs at this moment.

Excimer Laser no tratamento do vitiligo em 123 pacientes: estudo retrospectivo

Introduction: Vitiligo is cosmetically disfiguring and can cause significant psychological morbidity. Most therapies require protracted treatments and can lead to disappointing results. More recently, 308 nm Excimer laser has proven to be effective in treating vitiligo. Objective: To analyze the effectiveness and patient satisfaction of 308 nm Excimer treatment for vitiligo patches in a variety of locations on the body. Methods: Patients with generalized or localized vitiligo (n = 123, 321 lesions), were studied. The patients were treated at a private practice between 2007 and 2010. Two independent examiners analyzed the response to the therapy by comparing clinical and photographic records before and after treatment. Results: More than half (n = 77) of the patients presented repigmentation greater than 60%, 26 presented 40-59%, and 20% had levels less than 39%. Facial lesions responded better to treatment than those in other body parts. Elbows, hands and feet were the less sensitive areas. In general, the patients were satisfied with the treatment. Conclusion: The use of Excimer laser for treating vitiligo was effective and safe, producing satisfactory cosmetic results and improving patients' self esteem.

Differential effects of variation in athletes training on myocardial morphophysiological adaptation in men: Focus on I-123-MIBG assessed myocardial sympathetic activity

High intensity systematic physical training leads to myocardial morphophysiological adaptations. The goal of this study was to investigate if differences in training were correlated with differences in cardiac sympathetic activity.58 males (19-47 years), were divided into three groups: strength group (SG), (20 bodybuilders), endurance group (EG), (20 endurance athletes), and a control group (CG) comprising 18 healthy non-athletes. Cardiac sympathetic innervation was assessed by planar myocardial I-123-metaiodobenzylguanidine scintigraphy using the early and late heart to mediastinal (H/M) ratio, and washout rate (WR).Left ventricular mass index was significantly higher both in SG (P < .001) and EG (P = .001) compared to CG without a statistical significant difference between SG and EG (P = .417). The relative wall thickness was significantly higher in SG compared to CG (P < .001). Both left ventricular ejection fraction and the peak filling rate showed no significant difference between the groups. Resting heart rate was significantly lower in EG compared to CG (P = .006) and SG (P = .002). The late H/M ratio in CG was significantly higher compared to the late H/M for SG (P = .003) and EG (P = .004). However, WR showed no difference between the groups. There was no significant correlation between the parameters of myocardial sympathetic innervation and parameters of left ventricular function.Strength training resulted in a significant increase in cardiac dimensions. Both strength and endurance training seem to cause a reduction in myocardial sympathetic drive. However, myocardial morphological and functional adaptations to training were not correlated with myocardial sympathetic activity.

Ms. hebr. oct. 123 - [Sammelband in 10 Teilen: Handschriftenkonvolut]

Vorbesitzer: Abraham Merzbacher; viele Blätter sind falsch eingereiht, so daß eine eindeutige Zuordnung zu den einzelnen Teilen nicht immer möglich ist.