Opinion émise par Audouin contre la déclaration à exiger des ministres du culte : séance du 27 messidor an V ([Reprod.]) / Conseil des Cinq-cents

Collection : Les archives de la Révolution française ; 8.415

Advances in the pharmacological treatment of gastro-oesophageal cancer.

Despite a sharp decline in the incidence of gastric cancer during the second half of the 20th century, this malignancy remains the second leading cause of cancer mortality in the world. The incidence and mortality rate of gastric cancer increase with age; at present, the median ages at diagnosis are 67 years for men and 72 years for women in the US. This article reviews and discusses current medical treatment options for both the general population and elderly gastric cancer patients. Management of localized gastric cancer has changed significantly over recent years. Adjuvant chemoradiation is not generally recommended outside the US. After decades of trials of adjuvant chemotherapy with inconclusive results, a significant survival benefit for perioperative combination chemotherapy - as compared with surgery alone - in patients with resectable or locally advanced gastro-oesophageal cancer was recently demonstrated in the UK MAGIC trial. A further large, randomized trial from Japan demonstrated a significant survival benefit for adjuvant chemotherapy with S-1 after D2 resection for gastric cancer. However, both trials are applicable only to the population in which the trials were conducted. Specific data on elderly patients are missing. For patients with metastatic disease, oral fluoropyrimidines, such as capecitabine, have been developed. In Asian patients, treatment with the oral fluoropyrimidine S-1 is safe and effective. Docetaxel, oxaliplatin and irinotecan have demonstrated activity against gastric cancer in appropriately designed, randomized, phase III trials and have increased the available treatment options significantly. In addition, according to preliminary data, trastuzumab in combination with chemotherapy has significantly improved activity when compared to chemotherapy alone in patients with human epidermal receptor (HER)-2-positive gastric and gastro-oesophageal cancers. Thus, therapeutic decisions in patients with advanced gastric cancer may be adapted to the molecular subtype and co-morbidities of the individual patient. Data from retrospective analyses suggest that oxaliplatin seems to be better tolerated than cisplatin in elderly patients.

Quantification of magmatic and hydrothermal processes in a peralkaline syenite-alkali granite complex based on textures, phase equilibria, and stable and radiogenic isotopes

The Puklen complex of the Mid-Proterozoic Gardar Province, South Greenland, consists of various silica-saturated to quartz-bearing syenites, which are intruded by a peralkaline granite. The primary mafic minerals in the syenites are augite +/- olivine + Fe-Ti oxide + amphibole. Ternary feldspar thermometry and phase equilibria among mafic silicates yield T = 950-750degreesC, a(SiO2) = 0.7-1 and an f(O2) of 1-3 log units below the fayalite-magnetite-quartz (FMQ) buffer at 1 kbar. In the granites, the primary mafic minerals are ilmenite and Li-bearing arfvedsonite, which crystallized at temperatures below 750degreesC and at f(O2) values around the FMQ buffer. In both rock types, a secondary post-magmatic assemblage overprints the primary magmatic phases. In syenites, primary Ca-bearing minerals are replaced by Na-rich minerals such as aegirine-augite and albite, resulting in the release of Ca. Accordingly, secondary minerals include ferro-actinolite, (calcite-siderite)(ss), titanite and andradite in equilibrium with the Na-rich minerals. Phase equilibria indicate that formation of these minerals took place over a long temperature interval from near-magmatic temperatures down to similar to300degreesC. In the course of this cooling, oxygen fugacity rose in most samples. For example, late-stage aegirine in granites formed at the expense of arfvedsonite at temperatures below 300degreesC and at an oxygen fugacity above the haematite-magnetite (HM) buffer. The calculated delta(18)O(melt) value for the syenites (+5.9 to +6.3parts per thousand) implies a mantle origin, whereas the inferred delta(18)O(melt) value of <+5.1parts per thousand for the granitic melts is significantly lower. Thus, the granites require an additional low-delta(18)O contaminant, which was not involved in the genesis of the syenites. Rb/Sr data for minerals of both rock types indicate open-system behaviour for Rb and Sr during post-magmatic metasomatism. Neodymium isotope compositions (epsilonNd(1170 Ma) = -3.8 to -6.4) of primary minerals in syenites are highly variable, and suggest that assimilation of crustal rocks occurred to variable extents. Homogeneous epsilon(Nd) values of -5.9 and -6.0 for magmatic amphibole in the granites lie within the range of the syenites. Because of the very similar neodymium isotopic compositions of magmatic and late- to post-magmatic minerals from the same syenite samples a principally closed-system behaviour during cooling is implied. In contrast, for the granites an externally derived fluid phase is required to explain the extremely low epsilon(Nd) values of about -10 and low delta(18)O between +2.0 and +0.5parts per thousand for late-stage aegirine, indicating an open system in the late-stage history. In this study we show that the combination of phase equilibria constraints with stable and radiogenic isotope data on mineral separates can provide much better constraints on magma evolution during emplacement and crystallization than conventional whole-rock studies.

De Ate Homerica [et] Hesiodea

Dedicatio: Joseph Bremer [ruots. pr.], Abrahamus Paulin, Arvidus Paulin.

Método rápido de extração de DNA de bactérias

Desenvolveu-se um método rápido para extração de DNA de bactérias, que ao contrário de outros métodos, não requer o uso de enzimas, como lisozima e proteinase K, previamente, utilizado-se o carbonato de silício (carborundum) como agente físico para efetuar a quebrar da parede celular da bactéria. Com este método conseguiu-se extrair DNA bacteriano num menor tempo, além de mais rápido, ele mostrou-se mais simples e econômico, quando comparado aos métodos convencionais. O DNA obtido pode ser utilizado para diversas finalidades relacionadas ao DNA de bactérias, obtendo-se uma quantidade razoável de DNA, que varia de 725 µg/mL a 1170 µg/mL por cada 0,1 g de célula bacteriana, com ótima qualidade.

L'Univers

1870/07/22 (Numéro 1170).

Morbidade e mortalidade neonatais relacionadas à idade materna igual ou superior a 35 anos, segundo a paridade

OBJETIVO: avaliar a morbidade e a mortalidade neonatais relacionadas à idade materna igual ou superior a 35 anos. MÉTODOS: de 2.377 nascimentos em um ano, 316 (13,6%) eram de gestantes com idade igual ou superior a 35 anos. As gestantes selecionadas foram comparadas com mulheres entre 20 a 29 anos, randomicamente selecionadas entre 1170 delas (49,2%). Foram incluídas gestantes com idade gestacional acima de 22 semanas e recém nascido (RN) acima de 500 g. Foram excluídos 14 gemelares. Para avaliar a morbidade e a mortalidade foram consideradas as seguintes variáveis: índice de Apgar, peso ao nascer, malformações congênitas, adequação do peso ao nascer e a mortalidade neonatal até a alta hospitalar. RESULTADOS: quando avaliadas em conjunto nuliparas e multíparas, as gestantes com idade igual ou superior a 35 anos apresentaram uma proporção significativamente maior de resultados perinatais desfavoráveis, o que não se manteve quando foram excluídas as nulíparas. Multíparas com idade igual ou superior a 35 anos apresentaram maior proporção de índice de Apgar baixo no 1º minuto: 21,3 e 13,1% (p = 0,015); RN pequeno para a idade gestacional: 15,2 e 6,7% (p < 0,02); RN grande para a idade gestacional: 5,7 e 0,0% (p < 0,02); baixo peso ao nascer: 23,8 e 14,5% (p < 0,01) e prematuridade: 16,7 e 6,7% (p < 0,005), respectivamente. Não foram encontradas diferenças significativas para o índice Apgar baixo no 5º minuto, malformações congênitas, condições do recém-nascido no momento da alta hospitalar e mortalidade neonatal. CONCLUSÕES: ocorreu um aumento da morbidade neonatal nas gestantes com idade igual ou superior a 35 anos, porém sem aumento da mortalidade neonatal.

Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome

The etiology of respiratory distress syndrome (RDS) is multifactorial and multigenic. Studies have suggested that polymorphisms and mutations in the surfactant protein B (SP-B) gene are associated with the pathogenesis of RDS. The objectives of this study were to determine and compare the frequencies of SP-B gene polymorphisms in preterm babies with and without RDS. We studied 151 neonates: 79 preterm babies without RDS and 72 preterm newborns with RDS. The following four SP-B gene polymorphisms were analyzed: A/C at -18, C/T at 1580, A/G at 9306, and G/C at nucleotide 8714. The polymorphisms were detected by PCR amplification of genomic DNA and genotyping. The genotypes were determined using PCR-based converted restriction fragment length polymorphisms. The control group consisted of 42 (53%) girls and 37 (47%) boys. Weight ranged from 1170 to 3260 g and mean gestational age (GA) was 33.9 weeks (range: 29 to 35 weeks and 6 days). The RDS group consisted of 31 (43%) girls and 41 (57%) boys. Weight ranged from 614 to 2410 g and mean GA was 32 weeks (range: 26 to 35 weeks). The logistic regression model showed that GA was the variable that most contributed to the occurrence of RDS. The AG genotype of the A/G polymorphism at position 9306 of the SP-B gene was a protective factor in this population (OR = 0.1681; 95%CI = 0.0426-0.6629). We did not detect differences in the frequencies of the other polymorphisms between the two groups of newborns.

Le Petit journal. Supplément du dimanche

1913/04/20 (Numéro 1170).

L'Écho de Paris

1887/05/31 (Numéro 1170).

Evangeliarium ad usum ecclesiae Biterrensis.

F. 1 Temporal. F. 117 Sanctoral. F. 147 Commun des saints. F. 149 Messes diverses.

Horae ad usum romanum.

F. 1 Extraits des IV Évangiles et Passion selon s. Jean, suivie d'oraison. F. 8 Prières à la Vierge : « Obsecro te... », etc. F. 15 Matines et laudes de la Vierge. F. 41v Matines de la Croix (abrégées). F. 44 Matines du Saint-Esprit (abrégées). F. 46 Psaumes de la pénitence. F. 54v Litanies et « preces ». — L'office des morts et les suffrages manquent. F. 62 Calendrier (en français).

Mélanges sur l'histoire de la Champagne.

Contient : Chartes de l'abbaye de Montiéramey ; Extraits du nécrologe de la même abbaye ; Charte de Marie, duchesse de Bar, pour Montiéramey ; Vente faite au chapitre de Troyes par Jean de Vellery ; Extraits du cartulaire de Longuay (1170-1276), par Camuzat ; Titres de la commanderie du Temple de Troyes ; Chartes de Montiéramey ; Chartes du prieuré du Saint-Sépulcre ; Inventaire des titres de la maison de Brienne ; Notes sur Larrivour ; Pièces relatives à la maison de Brienne et de Luxembourg, rangées par ordre chronologique ; Testament de Robert de Colaverdey ; Testament d'Ysabeau de Flamericourt, veuve du précédent ; Pièces relatives à Jean et Pierre de Foicy ; Extrait d'un registre de l'évêque de Troyes ; Épitaphes de Troyes ; Extrait d'un registre de l'évêque de Troyes ; Chartes de l'abbaye de Trois-Fontaines ; Actes relatifs à la maison de Brienne-Luxembourg ; Union de la Maison-Dieu du Chêne à l'abbaye de Saint-Rémi de Reims ; Actes relatifs à la maison de Brienne ; Actes concernant les salines de Vic ; Arrêt du Parlement touchant la possession du comté de Roucy ; Arrêt du Parlement en faveur de l'Hôtel-Dieu de Corbeil contre Claude de Châtillon ; Donation du comté d'Eu au comte de Saint-Pol ; Renonciation par Ogier, sire de Gigny, à la dîme du « Meis Thiecelin », en faveur de l'église de Troyes ; Arrêt du Parlement de Paris concernant la maison de Salignac ; Fondation du monastère de Saint-Pierremont ; Chartes de l'abbaye de Trois-Fontaines ; Lettres de l'empereur Maximilien confirmant à François de Bourbon, comte de Saint-Pol, le comté de Roucy ; Note d'un missel de Jean de Saarebruck ; Donation faite par Jeanne de France, comtesse de Roussillon, à Jean d'Anneville ; Acquisition par Charles V des villes de Mouzon et Beaumont ; Testament de Jeanne de Champagne, reine de France ; Fragment d'une requête adressée au roi par les héritiers du sr de Couasnay ; Fondation de l'église de Notre-Dame de Rosnay par le comte Isembard ; Aveu rendu au roi par Claude de Dinteville ; Diplôme du roi Eudes pour Montiéramey ; Chartes de Montiérender

Recueil de chartes de commune.

Contient : Châteauvillain ; Troyes ; Nogaro en Armagnac ; Narbonne ; La Beuvrière (cf. fol. 73) ; Reims ; Troyes ; Beaumont ; Châteauvillain (1236 ; cf. fol. 2) ; La Chapelle [d'Angillon] ; Joigny ; Lorris ; Dixmont ; Montargis ; Barcelone (cf. fol. 149) ; Selens et Saint-Aubin ; La Beuvrière (cf. fol. 14) ; Chaumont ; Saint-Bris ; Saint-Laurent-sur-Barenjon ; Voisines ; Le Moulinet ; Barlieu ; Crespy [-en-Valois] ; Montdidier ; Laon ; Soissons ; Abbeville ; Compiègne ; Saint-Quentin ; Corbie ; Saint-Josse-sur-Mer ; La Fère ; Beauvais ; Nanteuil ; Courmelles ; Breteuil ; Beaumont-en-Argonne ; Chaumont ; Saint-Omer ; Vaux près Mouzon ; Vaux, Saconin, Mercin ; Chacrise ; Tournai ; Crandelain, etc ; Ambleteuse ; Morsain, etc ; Mantes ; Ferrières ; Aizy ; Pargny ; Saint-Riquier ; Soissons ; Saint-Martin d'Issoudun (cf. fol. 182) ; Rouen ; Dreux ; Meaux ; Reims ; Chablis ; Chatillon-sur-Seine ; Sens ; Auxerre ; Cerny ; Dixmont ; Étampes ; Orléans ; Bourges ; Issoudun (cf. fol. 148) ; Beaufort-en-Vallée ; La Rochelle ; Villefranche [d'Allier] ; Montauban ; Nevers ; Castres ; Toulouse ; Habitants de la Terre d'Albigeois ; Aigues-Mortes ; Lorrez-le-Bocage ; Le Puy ; Saint-Céré ; Barcelone ; Chatillon-sur-Marne ; Raucourt et Héraucourt ; Mézières ; Chatillon-sur-Marne ; Saint-Hellier ; Coutumes d'Anjou et du Maine ; Ervy-le-Chatel ; Cerres, Montceaux, Chaussepierre ; Notice sur un ms. de Chroniques françaises, de la bibliothèque de Colbert (= Duchesne 79)