Direct support and general support maintenance repair parts and special tools lists (including depot maintenance repair parts and special tools lists) : crane-shovel, crawler, mounted, 12-1/2 ton, 3/4 cu. yd, diesel engine driven (NSN 3810-00-869-3092) : Bucyrus-Erie model 22BM.

"December 1984."

Organizational maintenance repair parts and special tools lists : crane-shovel, crawler mounted, 12-1/2 ton, 3/4 cu. yd, diesel engine driven, NSN 3810-00-869-3092 : Bucyrus-Erie model 22BM.

Includes index.

Unit, direct support, and general support maintenance repair parts and special tools lists ... : crane-shovel, crawler mounted, 12-1/2-ton, 3/4 cu yd, diesel engine driven, NSN 3810-00-869-3092 : Bucyrus-Erie model 22BM.

"April 1992."

Revision of certain labor laws contained in chapters 1, 2, and 3 of title 40 of the Code of Virginia [relating to the Department of Labor and Industry, employment agencies, and the protection of employees] Report to the Governor and the General Assembly of Virginia.

Mode of access: Internet.

Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA), 3β-[N-(N',N'-Dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium propane (DOTAP):prolonged liposome retention mediates stronger Th1 responses

The immunostimulatory capacities of cationic liposomes are well-documented and are attributed both to inherent immunogenicity of the cationic lipid and more physical capacities such as the formation of antigen depots and antigen delivery. Very few studies have however been conducted comparing the immunostimulatory capacities of different cationic lipids. In the present study we therefore chose to investigate three of the most well-known cationic liposome-forming lipids as potential adjuvants for protein subunit vaccines. The ability of 3ß-[N-(N',N'-dimethylaminoethane)carbomyl] cholesterol (DC-Chol), 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), and dimethyldioctadecylammonium (DDA) liposomes incorporating immunomodulating trehalose dibehenate (TDB) to form an antigen depot at the site of injection (SOI) and to induce immunological recall responses against coadministered tuberculosis vaccine antigen Ag85B-ESAT-6 are reported. Furthermore, physical characterization of the liposomes is presented. Our results suggest that liposome composition plays an important role in vaccine retention at the SOI and the ability to enable the immune system to induce a vaccine specific recall response. While all three cationic liposomes facilitated increased antigen presentation by antigen presenting cells, the monocyte infiltration to the SOI and the production of IFN-? upon antigen recall was markedly higher for DDA and DC-Chol based liposomes which exhibited a longer retention profile at the SOI. A long-term retention and slow release of liposome and vaccine antigen from the injection site hence appears to favor a stronger Th1 immune response.

Expression of uncoupling proteins-1,-2 and-3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor

The abnormalities of lipid metabolism observed in cancer cachexia may be induced by a lipid-mobilizing factor produced by adenocarcinomas. The specific molecules and metabolic pathways that mediate the actions of lipid-mobilizing factor are not known. The mitochondrial uncoupling proteins-1, -2 and -3 are suggested to play essential roles in energy dissipation and disposal of excess lipid. Here, we studied the effects of lipid-mobilizing factor on the expression of uncoupling proteins-1, -2 and -3 in normal mice. Lipid-mobilizing factor isolated from the urine of cancer patients was injected intravenously into mice over a 52-h period, while vehicle was similarly given to controls. Lipid-mobilizing factor caused significant reductions in body weight (-10%, P=0.03) and fat mass (-20%, P<0.01) accompanied by a marked decrease in plasma leptin (-59%, P<0.01) and heavy lipid deposition in the liver. In brown adipose tissue, uncoupling protein-1 mRNA levels were elevated in lipid-mobilizing factor-treated mice (+96%, P<0.01), as were uncoupling proteins-2 and -3 (+57% and +37%, both P<0.05). Lipid-mobilizing factor increased uncoupling protein-2 mRNA in both skeletal muscle (+146%, P<0.05) and liver (+142%, P=0.03). The protein levels of uncoupling protein-1 in brown adipose tissue and uncoupling protein-2 in liver were also increased with lipid-mobilizing factor administration (+49% and +67%, both P=0.02). Upregulation by lipid-mobilizing factor of uncoupling proteins-1, -2 and -3 in brown adipose tissue, and of uncoupling protein-2 in skeletal muscle and liver, suggests that these uncoupling proteins may serve to utilize excess lipid mobilized during fat catabolism in cancer cachexia.

Vulnerabilidade ao Stress e Autoestima em Professores do 1.º, 2.º E 3.º Ciclo

Introdução: O stress condiciona o comportamento e desenvolvimento pessoal, podendo ter consequências preocupantes ao nível individual e organizacional. Os professores são uma classe reconhecida como estando sujeita a elevados níveis de stress, fator que prejudica a qualidade do ensino em geral. Objetivos: Avaliar a vulnerabilidade ao stress; identificar os principais fatores de stress e avaliar a correlação entre autoestima e stress, em professores do 1.º, 2.º e 3.º ciclos do ensino básico. Metodologia: Estudo correlacional, com uma amostra constituída por 60 professores do 1.º, 2.º e 3.º ciclos de escolaridade, de escolas do concelho de Leiria. Para a análise das variáveis em estudo foram aplicados: um questionário sociodemográfico; a Rosenberg Self-Esteem Scale (RSES); o Questionário de stress nos professores: ensino básico e secundário (QSPEBS) e a Escala de vulnerabilidade ao stress (23 QVS). Resultados: O estudo revela que 65% dos professores percecionam a profissão como stressante e que 30% são vulneráveis ao stress. O principal fator de stress identificado foi comportamentos inadequados/indisciplina dos alunos. Verificou-se uma correlação negativa entre a autoestima e a vulnerabilidade ao stress dos professores. Conclusão: Conclui-se que, quanto mais elevada é a auto-estima, menor é a vulnerabilidade dos professores ao stress e que, apesar de não se registarem níveis significativos de vulnerabilidade ao stress na população docente, a maioria dos professores perceciona a sua atividade profissional como geradora de elevados níveis de stress, sendo os comportamentos inadequados/indisciplina dos alunos o fator que mais contribui para o stress nos docentes. / Introduction: Stress affects behavior and personal development, and may have severe consequences either at the individual or organizational level. Teachers are identified as a class exposed to high levels of stress, factor that affects the quality of education in general. Objectives: To assess stress vulnerability; identify key stressors and assess the correlation between self-esteem and stress in primary and secondary school teachers. Methodology: A sociodemographic questionnaire and three self-report measures were administered to a sample of 60 primary and secondary teachers from Leiria district: the Rosenberg Self-Esteem Scale (RSES); a teachers stress questionnaire for primary, secondary and high school (QSPEBS) and a scale to access stress vulnerability (23 QVS). Results: The study reveals that 65% of teachers perceive the profession as stressful and that 30% are vulnerable to stress. The main stressor identified is inappropriate/disruptive behavior of students. There is a negative correlation between self-esteem and vulnerability to stress of teachers. Conclusion: We conclude that a higher self-esteem leads to less stress vulnerability in teachers and that, despite the non-significant level of vulnerability determined in this study, most teachers perceive their activity as stressful, being inappropriate/disruptive behavior of students the factor that most contributes for that.

Diseño de un modelo para promover emprendimiento en estudiantes de secundaria en grados 10° y 11° de estratos 1,2 y 3 en Colombia

páginas: 150

Presence of UV filters in surface water and the effects of phenylbenzimidazole sulfonic acid on rainbow trout (Oncorhynchus mykiss) following a chronic toxicity test

UV filters belong to a group of compounds that are used by humans and are present in municipal waste-waters, effluents from sewage treatment plants and surface waters. Current information regarding UV filters and their effects on fish is limited. In this study, the occurrence of three commonly used UV filters - 2-phenylbenzimidazole-5-sulfonic acid (PBSA), 2-hydroxy-4-methoxybenzophenone (benzophenone-3, BP-3) and 5-benzoyl-4-hydroxy-2-methoxy-benzenesulfonic acid (benzophenone-4, BP-4) - in South Bohemia (Czech Republic) surface waters is presented. PBSA concentrations (up to 13μgL(-1)) were significantly greater than BP-3 or BP-4 concentrations (up to 620 and 390ngL(-1), respectively). On the basis of these results, PBSA was selected for use in a toxicity test utilizing the common model organism rainbow trout (Oncorhynchus mykiss). Fish were exposed to three concentrations of PBSA (1, 10 and 1000µgL(-1)) for 21 and 42 days. The PBSA concentrations in the fish plasma, liver and kidneys were elevated after 21 and 42 days of exposure. PBSA increased activity of certain P450 cytochromes. Exposure to PBSA also changed various biochemical parameters and enzyme activities in the fish plasma. However, no pathological changes were obvious in the liver or gonads.

Fast-timing study of the l-forbidden 1/2(+) -> 3/2(+) M1 transition in Sn-129

The levels in Sn-129 populated from the beta(-) decay of In-129 isomers were investigated at the ISOLDE facility of CERN using the newly commissioned ISOLDE Decay Station (IDS). The lowest 1/2(+) state and the 3/2(+) ground state in 129Sn are expected to have configurations dominated by the neutron s(1/2) (l = 0) and d(3/2) (l = 2) single-particle states, respectively. Consequently, these states should be connected by a somewhat slow l-forbidden M1 transition. Using fast-timing spectroscopy we havemeasured the half-life of the 1/2(+) 315.3-keV state, T-1/2 = 19(10) ps, which corresponds to a moderately fast M1 transition. Shell-model calculations using the CD-Bonn effective interaction, with standard effective charges and g factors, predict a 4-ns half-life for this level. We can reconcile the shell-model calculations to the measured T-1/2 value by the renormalization of the M1 effective operator for neutron holes.

A metáfora e a imagem : estratégias pedagógicas no processo de ensino-aprendizagem na aula de Técnica de Dança Moderna com os alunos dos 2º e 3º anos do ensino vocacional na Academia de Dança Contemporânea de Setúbal

Relatório Final de Estágio apresentado à Escola Superior de Dança, com vista à obtenção do grau de Mestre emMetodologias do Ensino da Dança.

Cryopreservation of equine embryos with glycerol plus sucrose and glycerol plus 1,2-propanediol.

Six or 7-day-old equine embryos were divided into 4 groups; Group 1, n = 15, Day 7 embryos destined for immediate transfer; Group 2, n = 15, Day 6 embryos destined for deep-freezing with glycerol plus sucrose as cryoprotectant; Group 3, n = 10, Day 6 embryos destined for deep-freezing with glycerol plus 1,2-propanediol as cryoprotectant and Group 4, n = 3, fresh embryos destined for ultrastructural analysis. All the frozen/thawed embryos were transferred to recipient mares, except 3 embryos in Group 3 that were subjected to ultrastructural analysis. After thawing the cryoprotectants were removed by successive dilutions in PBS + 15% v:v fetal calf serum (FCS) containing decreasing concentrations of the cryoprotectants. Pregnancy was diagnosed ultrasonographically in 53.3%, 13.3% and 0% of the mares in Groups 1, 2 and 3 respectively. Ultrastructural analysis showed differences between frozen/thawed and fresh embryos. In the former, embryonic cells were deformed and showed dilation of the intercellular and perivitelline spaces, a decrease of desmosome number in the junctional complexes, few microvilli on the apical surface of the trophectoderm and an almost total absence of pinocytotic vesicles. Most of the mitochondria showed regions containing dilation and irregularities on the cristae, which appeared electron-dense. The results obtained with Groups 2 and 3 embryos showed that the cryoprotectants employed were not effective in protecting the embryos against damage during freezing and thawing. Indeed, the ultrastructural changes observed in the Group 3 embryos explained the absence of any established pregnancies in this group of mares.

Magnetic anomaly map of the Weddell Sea Region, Antarctic (Scale 1:2 500 000)

This paper describes a 1 : 2 500 000 scale aeromagnetic anomaly map produced by the joint efforts of VNIIOkeangeologia, Polar Marine Geological Research Expedition (PMGRE) and the Alfred Wegener Institute for Polar and Marine Research (AWl) for the Weddell Sea region covering 1 850 000 km' of West Antarctica. Extensive regional magnetic survey flights with line-spacing of about 20 km and 5 km were carried out by the PMGRE between 1977 and 1989. In course of these investigations the PMGRE flew 9 surveys with flight-line spacing of 20 km and 6 surveys with flight-line spacing of 5 km mainly over the mountain areas of southern Palmer Land, western Dronning Maud Land, Coats Land and Pensacola Mountains, over the Ronne lee Shelf and the Filchner Ice Shelf and the central part of the Weddell Sea. More than 215 000 line-kilometers of total field aeromagnetic data have been acquired by using an Ilyushin Il-14 ski-equipped aircraft. Survey operations were centered on the field base stations Druzhnaya-1, -2, and -3, from which the majority of the Weddell Sea region network was completed. The composite map of the Weddell Sea region is prepared in colour, showing magnetic anomaly contours at intervals of 50-100 nT with supplemental contours at an interval of 25 nT in low gradient areas, on a polar stereographic projection. The compiled colour magnetic anomaly map of the Weddell Sea region demonstrates that features of large areal extent, such as geologic provinces, fold-belts, ancient eratonic fragments and other regional structural features can be readily delineated. The map allows a comparison of regional magnetic features with similar-scale geological structures on geological and geophysical maps. It also provides a database for the future production of the ''Digital Magnetic Anomaly Map of Antarctica'' in the framework of the Scientific Committee on Antarctic Research/International Association of Geomagnetism and Aeronomy (SCAR/IAGA) compilation.

Hypervalent iodine in synthesis 93. A facile synthesis of 2-substituted imidazo[1,2-a]pyrimidines by cyclocondensation of alkynyl(phenyl)iodonium salts and 2-aminopyrimidine

Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts 1 with 2-aminopyrimidine 2 in chloroform under reflux for two hours in the presence of K2CO3 gave, after workup, the 2-substituted imidazo[1,2-]pyrimidines 3 in moderate to good yields. A possible mechanism for the formation of 3 involves the intramolecular cyclization of the intermediate alkylidenecarbene 6.