The pattern and Loci of training-induced brain changes in healthy older adults are predicted by the nature of the intervention.

There is enormous interest in designing training methods for reducing cognitive decline in healthy older adults. Because it is impaired with aging, multitasking has often been targeted and has been shown to be malleable with appropriate training. Investigating the effects of cognitive training on functional brain activation might provide critical indication regarding the mechanisms that underlie those positive effects, as well as provide models for selecting appropriate training methods. The few studies that have looked at brain correlates of cognitive training indicate a variable pattern and location of brain changes - a result that might relate to differences in training formats. The goal of this study was to measure the neural substrates as a function of whether divided attentional training programs induced the use of alternative processes or whether it relied on repeated practice. Forty-eight older adults were randomly allocated to one of three training programs. In the SINGLE REPEATED training, participants practiced an alphanumeric equation and a visual detection task, each under focused attention. In the DIVIDED FIXED training, participants practiced combining verification and detection by divided attention, with equal attention allocated to both tasks. In the DIVIDED VARIABLE training, participants completed the task by divided attention, but were taught to vary the attentional priority allocated to each task. Brain activation was measured with fMRI pre- and post-training while completing each task individually and the two tasks combined. The three training programs resulted in markedly different brain changes. Practice on individual tasks in the SINGLE REPEATED training resulted in reduced brain activation whereas DIVIDED VARIABLE training resulted in a larger recruitment of the right superior and middle frontal gyrus, a region that has been involved in multitasking. The type of training is a critical factor in determining the pattern of brain activation.

Kaaoksen ja järjestyksen jännitteessä : luonto-ohjelman The Nature of Rebirth hermeneuttinen sisällönluominen

Opinnäytetyöni on monimuototyö, jonka teososa on luonto-ohjelma/dokumenttielokuva The Nature of Rebirth, jonka toteutin yhteistyössä neljän muun opiskelijan kanssa. Toimin toisena käsikirjoittajana, ohjaajana ja tuottajana. Luonto-ohjelman keskeisenä ideana on kertoa luonnosta tavalla, joka korostaa ihmisen ja luonnon suhdetta, vuorovaikutusta sekä yhteenkietoutuneisuutta. Luonto-ohjelman aiheena on Euroopan vanhin metsä Bialowieza Puolassa. Kirjallisessa osiossa tarkastelen ja reflektoin luonto-ohjelman hermeneuttista sisällönluomista moniosaajan (käsikirjoittaja-ohjaaja-tuottajan) näkökulmasta. Hermeneuttisen sisällönluomisen käsite kuvastaa sitä prosessia, jonka kautta mielestäni lopullinen luonto-ohjelma luotiin. Se on työskentelytapa, joka perustuu kaaoksen ja järjestyksen väliseen jännitteeseen ja vuorovaikutukseen. Jännitteen ja vuorovaikutuksen kautta intuitiivisesta ideasta luodaan vaihe vaiheelta lopullista sisältöä. Hermeneuttinen sisällönluominen sopi tuotantoomme, jossa haasteena oli hakea muotoa ja tapaa kertoa Euroopan vanhimmasta metsästä ihmisten kautta. Hermeneuttinen sisällönluominen soveltuu sellaisille tuotannoille, joissa tekijällä on samanaikaisesti limittäin erilaisia pidemmän aikavälin tuotantoja. Rajaan tarkasteluni niihin tuotannon vaiheisiin, joissa hermeneuttinen sisällönluomisen prosessi oli suuressa roolissa joko omassa mielessäni tai työryhmän välisissä dialogeissa ja yhteistyössä. Nämä olivat ikään kuin solmukohtia, jotka piti ratkaista, jotta sisällönluominen olisi voinut taas jatkua. Luonto-ohjelman The Nature of Rebirth tuotannossa solmukohdat painottuivat erityisesti ennakkotuotantovaiheessa käsikirjoituksen luomiseen ja jälkituotantovaiheessa leikkausvaiheeseen. Solmukohtien lisäksi käsittelen luonto-ohjelmamme sisältöä laajemmassa yhteiskunnallisessa ja ohjelmavirran kontekstissa. Lähdekirjallisuutena olen käyttänyt sekä luonto-ohjelmiin että dokumenttielokuviin liittyviä teoksia ja artikkeleita. Lisäksi olen soveltanut monitieteisesti muiden tieteenalojen teorioita ja tutkimuksia, esimerkiksi hermeneuttisen sisällönluomisen viitekehyksessä. Osa tiedoista perustuu luentoihin Stadiassa tai keskusteluihin alan asiantuntijoiden kanssa. Lisäksi kirjallisessa osuudessa tuon esiin omia huomioitani sekä luonto-ohjelman tekijänä että luonto-ohjelmien katsojana.

Endogeneizing know-how flows through the nature of R&D investments

In this paper we carefully link knowledge flows to and from a firm s innovation process with this firm s investment decisions. Three types of investments are considered: investments in applied research, investments in basic research, and investments in intellectual property protection. Only when basic research is performed, can the firm effectively access incoming knowledge flows and these incoming spillovers serve to increase the efficiency of own applied research. The firm can at the same time influence outgoing knowledge flows, improving appropriability of its innovations, by investing in protection. Our results indicate that firms with small budgets for innovation will not invest in basic research. This occurs in the short run, when the budget for know-how creation is restricted, or in the long-run, when market opportunities are low, when legal protection is not very important, or, when the pool of accessible and relevant external know-how is limited. The ratio of basic to applied research is non-decreasing in the size of the pool of accessible external know-how, the size and opportunity of the market, and, the effectiveness of intellectual property rights protection. This indicates the existence of economies of scale in basic research due to external market related factors. Empirical evidence from a sample of innovative manufacturing firms in Belgium confirms the economies of scale in basic research as a consequence of the firm s capacity to access external knowledge flows and to protectintellectual property, as well as the complementarity between legal and strategic investments.

Martensitic transitions and the nature of ferromagnetism in the austenitic and martensitic states of Ni-Mn-Sn alloys

Structural and magnetic transformations in the Heusler-based system Ni0.50Mn0.50¿xSnx are studied by x-ray diffraction, optical microscopy, differential scanning calorimetry, and magnetization. The structural transformations are of austenitic-martensitic character. The austenite state has an L21 structure, whereas the structures of the martensite can be 10M , 14M , or L10 depending on the Sn composition. For samples that undergo martensitic transformations below and around room temperature, it is observed that the magnetic exchange in both parent and product phases is ferromagnetic, but the ferromagnetic exchange, characteristic of each phase, is found to be of different strength. This gives rise to different Curie temperatures for the austenitic and martensitic states.

Réhabilitation accélérée multimodate postcésarienne, la somme de toutes les astuces [Fast-track multimodal rehabilitation after cesarean, the sum of all tricks].

Fast-track multimodal rehabilitation after cesarean, the sum of all tricks Fast-track multimodal rehabilitation after caesarean is an interdisciplinary concept allowing an accelerated return to normal physiology. Fast-track rehabilitation combines minimising surgical trauma, regional anaesthesia and active management of pain control, minimally invasive postoperative care while promoting return to autonomy.

Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis.

INTRODUCTION: In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques to study brain microstructural alterations in early relapsing-remitting MS (RRMS) patients with minor deficits. Further, we investigated the potential use of advanced MRI to predict functional performances in these patients. METHODS: Brain relaxometry (T1, T2, T2*) and magnetization transfer MRI were performed at 3T in 36 RRMS patients and 18 healthy controls (HC). Multicontrast analysis was used to assess for microstructural alterations in normal-appearing (NA) tissue and lesions. A generalized linear model was computed to predict clinical performance in patients using multicontrast MRI data, conventional MRI measures as well as demographic and behavioral data as covariates. RESULTS: Quantitative T2 and T2* relaxometry were significantly increased in temporal normal-appearing white matter (NAWM) of patients compared to HC, indicating subtle microedema (P = 0.03 and 0.004). Furthermore, significant T1 and magnetization transfer ratio (MTR) variations in lesions (mean T1 z-score: 4.42 and mean MTR z-score: -4.09) suggested substantial tissue loss. Combinations of multicontrast and conventional MRI data significantly predicted cognitive fatigue (P = 0.01, Adj-R (2) = 0.4), attention (P = 0.0005, Adj-R (2) = 0.6), and disability (P = 0.03, Adj-R (2) = 0.4). CONCLUSION: Advanced MRI techniques at 3T, unraveled the nature of brain tissue damage in early MS and substantially improved clinical-radiological correlations in patients with minor deficits, as compared to conventional measures of disease.

The Pursuit of Efficient Copyright Licensing : How Some Rights Reserved Attempts to Solve the Problems of All Rights Reserved

This dissertation analyses the growing pool of copyrighted works, which are offered to the public using Creative Commons licensing. The study consist of analysis of the novel licensing system, the licensors, and the changes of the "all rights reserved" —paradigm of copyright law. Copyright law reserves all rights to the creator until seventy years have passed since her demise. Many claim that this endangers communal interests. Quite often the creators are willing to release some rights. This, however, is very difficult to do and needs help of specialized lawyers. The study finds that the innovative Creative Commons licensing scheme is well suited for low value - high volume licensing. It helps to reduce transaction costs on several le¬vels. However, CC licensing is not a "silver bullet". Privacy, moral rights, the problems of license interpretation and license compatibility with other open licenses and collecting societies remain unsolved. The study consists of seven chapters. The first chapter introduces the research topic and research questions. The second and third chapters inspect the Creative Commons licensing scheme's technical, economic and legal aspects. The fourth and fifth chapters examine the incentives of the licensors who use open licenses and describe certain open business models. The sixth chapter studies the role of collecting societies and whether two institutions, Creative Commons and collecting societies can coexist. The final chapter summarizes the findings. The dissertation contributes to the existing literature in several ways. There is a wide range of prior research on open source licensing. However, there is an urgent need for an extensive study of the Creative Commons licensing and its actual and potential impact on the creative ecosystem.

THE 'TWO TRUTHS' DOCTRINE (SATYADVAYA) AND THE NATURE OF UPĀYA IN NĀGĀRJUNA

ABSTRACT The objective of this article is to contribute to the understanding of Nāgārjuna's 'two truths' doctrine (satyadvaya) as presented in the Mūlamadhyamakakārikā ("The Fundamental Verses of the Middle Path") (XXIV.8-10). For that purpose, we argue that 'two truths' doctrine the basic structural framework for the operational functionality of upāya of upāya (lit., 'skilful means'), perhaps the most important epistemological/pedagogical notion of Mahāyāna Buddhism.

The nature of communication structures of university students in an international web-based computer-supported collaborative learning (CSCL) course

Communication, the flow of ideas and information between individuals in a social context, is the heart of educational experience. Constructivism and constructivist theories form the foundation for the collaborative learning processes of creating and sharing meaning in online educational contexts. The Learning and Collaboration in Technology-enhanced Contexts (LeCoTec) course comprised of 66 participants drawn from four European universities (Oulu, Turku, Ghent and Ramon Llull). These participants were split into 15 groups with the express aim of learning about computer-supported collaborative learning (CSCL). The Community of Inquiry model (social, cognitive and teaching presences) provided the content and tools for learning and researching the collaborative interactions in this environment. The sampled comments from the collaborative phase were collected and analyzed at chain-level and group-level, with the aim of identifying the various message types that sustained high learning outcomes. Furthermore, the Social Network Analysis helped to view the density of whole group interactions, as well as the popular and active members within the highly collaborating groups. It was observed that long chains occur in groups having high quality outcomes. These chains were also characterized by Social, Interactivity, Administrative and Content comment-types. In addition, high outcomes were realized from the high interactive cases and high-density groups. In low interactive groups, commenting patterned around the one or two central group members. In conclusion, future online environments should support high-order learning and develop greater metacognition and self-regulation. Moreover, such an environment, with a wide variety of problem solving tools, would enhance interactivity.

Rising to the impossible challenge: the storage of all research data, forever?

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014