Comparison of HMM and SDTW for Tamil handwritten character recognition

In this paper, we compare the experimental results for Tamil online handwritten character recognition using HMM and Statistical Dynamic Time Warping (SDTW) as classifiers. HMM was used for a 156-class problem. Different feature sets and values for the HMM states & mixtures were tried and the best combination was found to be 16 states & 14 mixtures, giving an accuracy of 85%. The features used in this combination were retained and a SDTW model with 20 states and single Gaussian was used as classifier. Also, the symbol set was increased to include numerals, punctuation marks and special symbols like $, & and #, taking the number of classes to 188. It was found that, with a small addition to the feature set, this simple SDTW classifier performed on par with the more complicated HMM model, giving an accuracy of 84%. Mixture density estimation computations was reduced by 11 times. The recognition is writer independent, as the dataset used is quite large, with a variety of handwriting styles.

Time Series Classification for Online Tamil Handwritten Character Recognition – A Kernel Based Approach

In this paper, we consider the problem of time series classification. Using piecewise linear interpolation various novel kernels are obtained which can be used with Support vector machines for designing classifiers capable of deciding the class of a given time series. The approach is general and is applicable in many scenarios. We apply the method to the task of Online Tamil handwritten character recognition with promising results.

Interplay of localized and itinerant character of Ru ions: Tl2Ru2O7 versus Hg2Ru2O7

We carry out a comparative study of the electronic structure of two pyrochlore ruthenate compounds, Tl2Ru2O7 and Hg2Ru2O7, in terms of first principles calculations. Our study reveals the Ru d electrons in Hg2Ru2O7 to be much more delocalized compared to that in Tl2Ru2O7. The subtle change in the Ru-d bandwidths in the two compounds, triggered by the differences in Hg 5d-Ru 4d hybridization compared to that of Tl 5d-Ru 4d, bring in the observed differences in behavior. Our study further shows that the development of long range noncollinear antiferromagnetic structure at low temperature is sufficient to produce the insulating solution in Hg2Ru2O7, in line with the prediction from recent nuclear magnetic resonance study.

Monoclonal Antibodies against Hepatitis C Genotype 3a Virus Like Particle Inhibit Virus Entry in Cell Culture System

The envelope protein (E1-E2) of Hepatitis C virus (HCV) is a major component of the viral structure. The glycosylated envelope protein is considered to be important for initiation of infection by binding to cellular receptor(s) and also known as one of the major antigenic targets to host immune response. The present study was aimed at identifying mouse monoclonal antibodies which inhibit binding of virus like particles of HCV to target cells. The first step in this direction was to generate recombinant HCV-like particles (HCV-LPs) specific for genotypes 3a of HCV (prevalent in India) using the genes encoding core, E1 and E2 envelop proteins in a baculovirus expression system. The purified HCV-LPs were characterized by ELISA and electron microscopy and were used to generate monoclonal antibodies (mAbs) in mice. Two monoclonal antibodies (E8G9 and H1H10) specific for the E2 region of envelope protein of HCV genotype 3a, were found to reduce the virus binding to Huh7 cells. However, the mAbs generated against HCV genotype 1b (D2H3, G2C7, E1B11) were not so effective. More importantly, mAb E8G9 showed significant inhibition of the virus entry in HCV JFH1 cell culture system. Finally, the epitopic regions on E2 protein which bind to the mAbs have also been identified. Results suggest a new therapeutic strategy and provide the proof of concept that mAb against HCV-LP could be effective in preventing virus entry into liver cells to block HCV replication.

Maximum magnitude estimation considering the regional rupture character

The main objective of the paper is to develop a new method to estimate the maximum magnitude (M (max)) considering the regional rupture character. The proposed method has been explained in detail and examined for both intraplate and active regions. Seismotectonic data has been collected for both the regions, and seismic study area (SSA) map was generated for radii of 150, 300, and 500 km. The regional rupture character was established by considering percentage fault rupture (PFR), which is the ratio of subsurface rupture length (RLD) to total fault length (TFL). PFR is used to arrive RLD and is further used for the estimation of maximum magnitude for each seismic source. Maximum magnitude for both the regions was estimated and compared with the existing methods for determining M (max) values. The proposed method gives similar M (max) value irrespective of SSA radius and seismicity. Further seismicity parameters such as magnitude of completeness (M (c) ), ``a'' and ``aEuro parts per thousand b `` parameters and maximum observed magnitude (M (max) (obs) ) were determined for each SSA and used to estimate M (max) by considering all the existing methods. It is observed from the study that existing deterministic and probabilistic M (max) estimation methods are sensitive to SSA radius, M (c) , a and b parameters and M (max) (obs) values. However, M (max) determined from the proposed method is a function of rupture character instead of the seismicity parameters. It was also observed that intraplate region has less PFR when compared to active seismic region.

Development of an ex vivo organ culture model using human gastro-intestinal tissue and Campylobacter jejuni.

Campylobacter jejuni is an important food-borne pathogen. However, relatively little is understood regarding its pathogenesis, and research is hampered by the lack of a suitable model. Recently, a number of groups have developed assays to study the pathogenic mechanisms of C. jejuni using cell culture models. Here, we report the development of an ex vivo organ culture model, allowing for the maintenance of intestinal mucosal tissue, to permit more complex host-bacterium interactions to be studied. Ex vivo organ culture highlights the propensity for C. jejuni to adhere to mucosal tissue via the flagellum, either as discrete colonies or as multicellular units.

Exploiting Chinese character models to improve speech recognition performance

The Chinese language is based on characters which are syllabic in nature. Since languages have syllabotactic rules which govern the construction of syllables and their allowed sequences, Chinese character sequence models can be used as a first level approximation of allowed syllable sequences. N-gram character sequence models were trained on 4.3 billion characters. Characters are used as a first level recognition unit with multiple pronunciations per character. For comparison the CU-HTK Mandarin word based system was used to recognize words which were then converted to character sequences. The character only system error rates for one best recognition were slightly worse than word based character recognition. However combining the two systems using log-linear combination gives better results than either system separately. An equally weighted combination gave consistent CER gains of 0.1-0.2% absolute over the word based standard system. Copyright © 2009 ISCA.

La participación política de los intelectuales durante la transición democrática : el Grupo Esmeralda y el prresidente Alfonsín

Resumen: El presente artículo tiene por objeto analizar las relaciones que se establecieron entre un grupo de intelectuales de izquierda y el presidente radical Raúl Alfonsín durante la transición democrática en la Argentina. Se describirán en primer lugar los desplazamientos teóricos de la izquierda intelectual marcados por el exilio mexicano; en segundo lugar, las características del campo cultural en la transición democrática en los ochenta, centrándose en la producción de los intelectuales vinculados con la revista Punto de Vista y el Club de Cultura Socialista y, por último, los vínculos que se establecieron entre el presidente Alfonsín y los intelectuales de la izquierda renovada, analizando los dilemas ético-políticos que debieron enfrentar. La construcción de sentido en torno a un personaje político, en el que los intelectuales veían la posibilidad de que se convirtiera en un moderno líder socialdemócrata, es la hipótesis a partir de la cual intenta explicarse la vinculación, siguiendo las teorías de Pierre Bourdieu.

El Matadero de Esteban Echeverría, o la inauguración de los mataderos

Resumen: En el presente texto retomamos y reconocemos el carácter de ‘texto fundante’ que El Matadero de Esteban Echeverría tiene en nuestra cultura argentina. Analizamos lo enraizado del texto conectándolo hacia atrás, con los orígenes de la gauchesca, y hacia adelante, con su culminación y con sus proyecciones, incluso en diversas disciplinas. Luego podemos centrarnos en el tema de la violencia como recurrente no solo literario, y precisar el sentido en que la tomamos. Sostenemos que la violencia de El Matadero ya estaba presente, de manera velada, en otras obras de Echeverría; no tanto por su tematización, sino porque figurativiza, de manera muy acorde con la ideología románticas, razón y corazón, considerado éste no como exclusiva sede de sentimientos, sino como víscera, y de allí sus equivalentes, como el estómago y el matambre. Esta parte visceral no accede a mayor formulación, porque no entra en el programa de la estética en boga. Desde este punto de vista, releo las quejas debidas al sufrimiento del corazón, y entiendo el llanto y el descontento de otro modo. Hay lamento porque nada, al menos en el terreno literario, brinda salida a ese fondo vivo, no esquemático y que le resulta abyecto, porque encierra un modo y un contenido que no puede reconocer como propios. Asociado con esta cara puesta en sombra, inopinadamente, El matadero vuelve a ser texto fundante, pero de otra parte de la literatura argentina: de lo marginal, que no puede sumarse a proyectos, y que muy pocos dicen.

A Novel Counter Sheet-Flow Sandwich Cell Culture Device For Mammalian Cell Growth In Space

Cell culture and growth in space is crucial to understand the cellular responses under microgravity. The effects of microgravity were coupled with such environment restrictions as medium perfusion, in which the underlying mechanism has been poorly understood. In the present work, a customer-made counter sheet-flow sandwich cell culture device was developed upon a biomechanical concept from fish gill breathing. The sandwich culture unit consists of two side chambers where the medium flow is counter-directional, a central chamber where the cells are cultured, and two porous polycarbonate membranes between side and central chambers. Flow dynamics analysis revealed the symmetrical velocity profile and uniform low shear rate distribution of flowing medium inside the central culture chamber, which promotes sufficient mass transport and nutrient supply for mammalian cell growth. An on-orbit experiment performed on a recovery satellite was used to validate the availability of the device.