Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network

Neuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or resting-state analysis, may help to clarify this issue. Using such approaches, alterations in the default-mode and salience networks (SNs) have been described in Alzheimer's, although their relationship with specific symptoms remains unclear. We therefore carried out resting-state functional connectivity analysis with 20 patients with mild to moderate AD, and correlated their scores on neuropsychiatric inventory syndromes (apathy, hyperactivity, affective syndrome, and psychosis) with maps of connectivity in the default mode network and SN. In addition, we compared network connectivity in these patients with that in 17 healthy elderly control subjects. All analyses were controlled for gray matter density and other potential confounds. Alzheimer's patients showed increased functional connectivity within the SN compared with controls (right anterior cingulate cortex and left medial frontal gyrus), along with reduced functional connectivity in the default-mode network (bilateral precuneus). A correlation between increased connectivity in anterior cingulate cortex and right insula areas of the SN and hyperactivity syndrome (agitation, irritability, aberrant motor behavior, euphoria, and disinhibition) was found. These findings demonstrate an association between specific network changes in AD and particular neuropsychiatric symptom types. This underlines the potential clinical significance of resting state alterations in future diagnosis and therapy. © 2013 Wiley Periodicals, Inc.

Previsão de cargas elétricas através de um modelo híbrido de regressão com redes neurais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização de leite utilizando técnicas de ultra-som e redes neurais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Um novo modelo de transformadores trifásicos para análise harmônica trifásica em sistemas de distribuição

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Geração de algoritmos de escalonamento para simulação de grades computacionais

Pós-graduação em Ciência da Computação - IBILCE

Jornalismo online: a construção da notícia a partir do twitter no caso da falsa morte de Amin Khader

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Geografia de redes e da logística no transporte rodoviário de cargas: fluxos e mobilidade geográfica do capital

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Redes de transformação do processo de inovação: o caminho entre a descoberta e a comercialização

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Periódicos científicos eletrônicos: apresentação de modelo para análise de estrutura

Pós-graduação em Ciência da Informação - FFC

Monitoramento da integridade em estruturas aeronáuticas

Pós-graduação em Engenharia Mecânica - FEIS

The advance of cloud computing

The “Implementation of the National Data Centre” project, Augusto Espín, Deputy Minister of Telecommunications and Information Society, Ecuador .-- Cloud computing and public policy in Brazil, Rafael Henrique Rodrigues Moreira, Ministry of Science, Technology and Innovation, Brazil .-- “The cloud is being taken up more quickly in Latin America than in the rest of the world”, interview to Lalo Steinmann, Microsoft .-- The impact of education and research networks on the development of cloud computing Eduardo Vera, University of Chile .-- “The cloud helps to narrow divides by providing access to technology resources that used to be unaffordable”, interview to Luis Urzúa, Movistar Chile .-- “Cloud computing will be a strategic sector of the economy in the coming years”, interview to Jean-Bernard Gramunt, France’s digital strategy .-- “If take-up in Latin America is as strong as predicted, it will be a good opportunity to create and export technology”, interview to Flavio Junqueira, Yahoo! Labs.

Risco de crédito: uma abordagem utilizando análise discriminante, regressão logística e redes neurais artificiais

Considering the relevance of researches concerning credit risk, model diversity and the existent indicators, this thesis aimed at verifying if the Fleuriet Model contributes in discriminating Brazilian open capital companies in the analysis of credit concession. We specifically intended to i) identify the economic-financial indicators used in credit risk models; ii) identify which economic-financial indicators best discriminate companies in the analysis of credit concession; iii) assess which techniques used (discriminant analysis, logistic regression and neural networks) present the best accuracy to predict company bankruptcy. To do this, the theoretical background approached the concepts of financial analysis, which introduced themes relative to the company evaluation process; considerations on credit, risk and analysis; Fleuriet Model and its indicators, and, finally, presented the techniques for credit analysis based on discriminant analysis, logistic regression and artificial neural networks. Methodologically, the research was defined as quantitative, regarding its nature, and explanatory, regarding its type. It was developed using data derived from bibliographic and document analysis. The financial demonstrations were collected by means of the Economática ® and the BM$FBOVESPA website. The sample was comprised of 121 companies, being those 70 solvents and 51 insolvents from various sectors. In the analyses, we used 22 indicators of the Traditional Model and 13 of the Fleuriet Model, totalizing 35 indicators. The economic-financial indicators which were a part of, at least, one of the three final models were: X1 (Working Capital over Assets), X3 (NCG over Assets), X4 (NCG over Net Revenue), X8 (Type of Financial Structure), X9 (Net Thermometer), X16 (Net Equity divided by the total demandable), X17 (Asset Turnover), X20 (Net Equity Profitability), X25 (Net Margin), X28 (Debt Composition) and X31 (Net Equity over Asset). The final models presented setting values of: 90.9% (discriminant analysis); 90.9% (logistic regression) and 97.8% (neural networks). The modeling in neural networks presented higher accuracy, which was confirmed by the ROC curve. In conclusion, the indicators of the Fleuriet Model presented relevant results for the research of credit risk, especially if modeled by neural networks.

A utilização das tecnologias da informação e comunicação no ensino dos 100 metros rasos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A vulnerabilidade no esporte e a exposição às novas mídias: um estudo sobre o twitter

Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC

Redes sociais temáticas: o caso das redes sociais de assistência à criança e ao adolescente em Presidente Prudente (SP) e suas representações sociais

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)