OpLegis: Programa de gestió per a l'advocat d'ofici

Aquest projecte final del Màster de Programari Lliure, consisteix en el desenvolupament d'unprograma informàtic via web per la gestió integral de l'advocat d'ofici. Fent un estudi de projectes existents a sourceforge, cap d'ells s'adequa a la idea que es voldesenvolupar, per tant, es decideix a crear un Sistema d'Informació des de zero.

Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients.

Background. DNA-damage assays, quantifying the initial number of DNA double-strand breaks induced by radiation, have been proposed as a predictive test for radiation-induced toxicity. Determination of radiation-induced apoptosis in peripheral blood lymphocytes by flow cytometry analysis has also been proposed as an approach for predicting normal tissue responses following radiotherapy. The aim of the present study was to explore the association between initial DNA damage, estimated by the number of double-strand breaks induced by a given radiation dose, and the radio-induced apoptosis rates observed. Methods. Peripheral blood lymphocytes were taken from 26 consecutive patients with locally advanced breast carcinoma. Radiosensitivity of lymphocytes was quantified as the initial number of DNA double-strand breaks induced per Gy and per DNA unit (200 Mbp). Radio-induced apoptosis at 1, 2 and 8 Gy was measured by flow cytometry using annexin V/propidium iodide. Results. Radiation-induced apoptosis increased in order to radiation dose and data fitted to a semi logarithmic mathematical model. A positive correlation was found among radio-induced apoptosis values at different radiation doses: 1, 2 and 8 Gy (p < 0.0001 in all cases). Mean DSB/Gy/DNA unit obtained was 1.70 ± 0.83 (range 0.63-4.08; median, 1.46). A statistically significant inverse correlation was found between initial damage to DNA and radio-induced apoptosis at 1 Gy (p = 0.034). A trend toward 2 Gy (p = 0.057) and 8 Gy (p = 0.067) was observed after 24 hours of incubation. Conclusions. An inverse association was observed for the first time between these variables, both considered as predictive factors to radiation toxicity.

The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer

Background: We aim to investigate the possibility of using 18F-positron emission tomography/computer tomography (PET-CT) to predict the histopathologic response in locally advanced rectal cancer (LARC) treated with preoperative chemoradiation (CRT). Methods: The study included 50 patients with LARC treated with preoperative CRT. All patients were evaluated by PET-CT before and after CRT, and results were compared to histopathologic response quantified by tumour regression grade (patients with TRG 1-2 being defined as responders and patients with grade 3-5 as non-responders). Furthermore, the predictive value of metabolic imaging for pathologic complete response (ypCR) was investigated. Results: Responders and non-responders showed statistically significant differences according to Mandard's criteria for maximum standardized uptake value (SUVmax) before and after CRT with a specificity of 76,6% and a positive predictive value of 66,7%. Furthermore, SUVmax values after CRT were able to differentiate patients with ypCR with a sensitivity of 63% and a specificity of 74,4% (positive predictive value 41,2% and negative predictive value 87,9%); This rather low sensitivity and specificity determined that PET-CT was only able to distinguish 7 cases of ypCR from a total of 11 patients. Conclusions: We conclude that 18-F PET-CT performed five to seven weeks after the end of CRT can visualise functional tumour response in LARC. In contrast, metabolic imaging with 18-F PET-CT is not able to predict patients with ypCR accurately

Asma del adulto : proceso asistencial integrado

Este documento (2004), junto con el de Asma en la edad pediátrica (2003), han sido unificados en un único Proceso Asistencial Integrado: Asma (2012)[http://hdl.handle.net/10668/674]. Publicado en la página web de la Consejería de Salud y Bienestar Social: www.juntadeandalucia.es/salud (Consejería de Salud y Bienestar Social/ Profesionales / Nuestro Compromiso por la Calidad / Proceso Asistencial Integrado Asma / Histórico de documentos del PAI Asma)

Taula rodona entorn de les 'Regles de esquivar vocables i mots grossers o pagesívols': Intervenció d'Albert Rossich

Intervenció lliure d’Albert Rossich en la taula rodona entorn de les 'Regles de esquivar vocables i mots grossers o pagesívols', què va tenir lloc el 15 de gener de 2004 a la Sala de Graus de la Facultat de Filologia de la Universitat de Barcelona. Aquesta taula rodona se situa en el marc d’un Seminari de Cultura Catalana i Moderna coordinat per Lola Badia i Eulàlia Duran, del Departament de Filologia Catalana de la mateixa Universitat. Hi van participar Antoni Maria Badia i Margarit, Germà Colón, Antoni Ferrando i Mariàngela Vilallonga ; Agustí Alcoberro hi va actuar de moderador

Plan andaluz de Alzheimer 2007-2010

Publicado en la página web de la Consejería de Igualdad, Salud y Políticas Sociales: www.juntadeandalucia.es/salud (Consejería de Igualdad, Salud y Políticas sociales / Ciudadanía / Quiénes Somos / Planes y Estrategias / Plan Andaluz de Alzheimer)

Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy

BACKGROUND. Either higher levels of initial DNA damage or lower levels of radiation-induced apoptosis in peripheral blood lymphocytes have been associated to increased risk for develop late radiation-induced toxicity. It has been recently published that these two predictive tests are inversely related. The aim of the present study was to investigate the combined role of both tests in relation to clinical radiation-induced toxicity in a set of breast cancer patients treated with high dose hyperfractionated radical radiotherapy. METHODS. Peripheral blood lymphocytes were taken from 26 consecutive patients with locally advanced breast carcinoma treated with high-dose hyperfractioned radical radiotherapy. Acute and late cutaneous and subcutaneous toxicity was evaluated using the Radiation Therapy Oncology Group morbidity scoring schema. The mean follow-up of survivors (n = 13) was 197.23 months. Radiosensitivity of lymphocytes was quantified as the initial number of DNA double-strand breaks induced per Gy and per DNA unit (200 Mbp). Radiation-induced apoptosis (RIA) at 1, 2 and 8 Gy was measured by flow cytometry using annexin V/propidium iodide. RESULTS. Mean DSB/Gy/DNA unit obtained was 1.70 ± 0.83 (range 0.63-4.08; median, 1.46). Radiation-induced apoptosis increased with radiation dose (median 12.36, 17.79 and 24.83 for 1, 2, and 8 Gy respectively). We observed that those "expected resistant patients" (DSB values lower than 1.78 DSB/Gy per 200 Mbp and RIA values over 9.58, 14.40 or 24.83 for 1, 2 and 8 Gy respectively) were at low risk of suffer severe subcutaneous late toxicity (HR 0.223, 95%CI 0.073-0.678, P = 0.008; HR 0.206, 95%CI 0.063-0.677, P = 0.009; HR 0.239, 95%CI 0.062-0.929, P = 0.039, for RIA at 1, 2 and 8 Gy respectively) in multivariate analysis. CONCLUSIONS. A radiation-resistant profile is proposed, where those patients who presented lower levels of initial DNA damage and higher levels of radiation induced apoptosis were at low risk of suffer severe subcutaneous late toxicity after clinical treatment at high radiation doses in our series. However, due to the small sample size, other prospective studies with higher number of patients are needed to validate these results.

Propuesta de plan de manejo de San Miguel de los Baños

Estudi de la localitat de San Miguel de los Baños (Cuba) segons el punt de vista de l’ecoturisme per tal de proposar la zona com a àrea protegida i evitar la seva degradació

Anàlisi del flux de materials del sector de la fusta a Catalunya per l’any 2005

Anàlisi del flux de manterials que travessen el sector de la fusta a Catalunya durant l’any 2005 calculant els balanços de matèria i els indicadors derivats, de cara a avaluar la gestió dels boscos a Catalunya

Pla de difusió del Patrimoni Cultural de Pineda de Mar. Tot el que hi ha i no veus

Les idees que han portat a realitzar aquest projecte són les següents: posar en valor i donar a conèixer la realitat patrimonial que té Pineda de Mar, conèixer i documentar el patrimoni cultural de Pineda, actualitzar l’inventari d’elements declarats al municipi, oferir a la ciutat la possibilitat de tenir un turisme cultural, no només un turisme de sol i platja, ser un projecte útil i factible per a l’ajuntament del municipi.Aquestes idees o raons han estat el rerefons per a encaminar i decidir el projecte final de difusió que es presenta en aquest treball.

Instal·lació d'energia fotovoltaica d'una casa de colònies

Els objectius d'aquest projecte són el disseny d'una instal·lació fotovoltaica connectada a xarxa que sigui capaç de produir la mateixa quantitat d’energia que consumeix la casa de colònies a on es troba ubicada. La particularitat d’aquesta instal·lació serà que els generadors fotovoltaics aniran sobra una plataforma giratòria que seguirà el sol buscant sempre la millor i major producció energètica. El control d'aquesta estructura anirà a càrrec d'un autòmat programable. Aprofitant l'existència de panells fotovoltaics, s'ha dissenyat un sistema d’acumulació d’energia de 2 kW de potència que dotarà de corrent una línia que, en cas de falla en el sistema d’alimentació general, es mantindrà ininterrompuda. Aquesta línia serà de 230 V i està dissenyada per tenir una autonomia de 2 hores

Use of palliative radiotherapy in brain and bone metastases (VARA II study).

INTRODUCTION Metastases are detected in 20% of patients with solid tumours at diagnosis and a further 30% after diagnosis. Radiation therapy (RT) has proven effective in bone (BM) and brain (BrM) metastases. The objective of this study was to analyze the variability of RT utilization rates in clinical practice and the accessibility to medical technology in our region. PATIENTS AND METHODS We reviewed the clinical records and RT treatment sheets of all patients undergoing RT for BM and/or BrM during 2007 in the 12 public hospitals in an autonomous region of Spain. Data were gathered on hospital type, patient type and RT treatment characteristics. Calculation of the rate of RT use was based on the cancer incidence and the number of RT treatments for BM, BrM and all cancer sites. RESULTS Out of the 9319 patients undergoing RT during 2007 for cancer at any site, 1242 (13.3%; inter-hospital range, 26.3%) received RT for BM (n = 744) or BrM (n = 498). These 1242 patients represented 79% of all RT treatments with palliative intent, and the most frequent primary tumours were in lung, breast, prostate or digestive system. No significant difference between BM and BrM groups were observed in: mean age (62 vs. 59 yrs, respectively); gender (approximately 64% male and 36% female in both); performance status (ECOG 0-1 in 70 vs. 71%); or mean distance from hospital (36 vs. 28.6 km) or time from consultation to RT treatment (13 vs. 14.3 days). RT regimens differed among hospitals and between patient groups: 10 × 300 cGy, 5 × 400 cGy and 1x800cGy were applied in 32, 27 and 25%, respectively, of BM patients, whereas 10 × 300cGy was used in 49% of BrM patients. CONCLUSIONS Palliative RT use in BM and BrM is high and close to the expected rate, unlike the global rate of RT application for all cancers in our setting. Differences in RT schedules among hospitals may reflect variability in clinical practice among the medical teams.

Aplicació de gestió de rutes d'operari i incidències d'instal·lacions sobre PDA amb sincronització remota

Una empresa destinada al sector de la informàtica vol crear un nou producte basat en PDA (Personal Digital Assistant), per tal d’oferir noves prestacions als clients actuals, així com poder ampliar la cartera de clients. El producte està destinat a clients de servei tècnic d’instal·lacions (gas, llum, aigua...), els quals tenen diferents tècnics que, basant-se en una ruta establerta, realitzen tasques de manteniment i reparació de les diferents instal·lacions dels clients. Utilitzant la tecnologia .NET amb l’entorn de desenvolupament Visual Studio 2005 i base de dades SQL Server 2005, s’ha creat una aplicació per a PDA que permeti la informatització de tots els processos de gestió de rutes per part dels tècnics