880 resultados para Water ethanol 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide


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Thesis (doctoral)--Universitat zu Rostock.

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Thesis (doctoral)--

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Thesis (doctoral)--

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Thesis (doctoral)--Universitt Jena, 1896.

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Thesis (doctoral)--Universitat Rostock, 1906.

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Thesis (doctoral)--

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Thesis (doctoral)--

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Thesis (doctoral)--

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In Filipino infants, 1 dose of an adjuvanted, 11-valent pneumococcal conjugate vaccine (serotypes 1, 4, 5, 7F, 9V, 19F, and 23F conjugated to tetanus protein; and serotypes 3, 6B, 14, and 18C conjugated to diphtheria toxoid) administered alone at age 18 weeks (11PncTD1) elicited similar antibody concentrations at age 9 months as those elicited by 3 doses (11PncTD3) administered concomitantly with national program vaccines, at ages 6, 10, and 14 weeks. Geometric mean antibody concentrations ranged from 0.36 mug/mL ( for serotype 18C) to 5.81 mug/mL (for serotype 4), for the 11PncTD1 vaccine, and from 0.32 mug/mL (for serotype 18C) to 5.01 mug/mL (for serotype 19F), for the 11PncTD3 vaccine. The proportion of infants with threshold antibody concentrations greater than or equal to0.35 mug/mL was also similar (ranges, 55.6%-100% for the 11PncTD1 vaccine and 42.9%-100% for the 11PncTD3 vaccine). The functional activity of antibodies expressed as opsonophagocytic activity titers was similar in the 11PncTD1 and 11PncTD3 groups. This finding is an important one for countries with financial constraints and high pneumococcal disease burden.

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3-Fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines (14, 16, and 18-22) are highly potent and selective inhibitors of phenylethanolamine N-methyltransferase (PNMT). Molecular modeling studies with 3-fluoromethyl-7-(N-alkyl aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines, such as 16, suggested that the sulfonamide -NH-could form a hydrogen bond with the side chain of Lys57. However, SAR studies and analysis of the crystal structure of human PNMT (hPNMT) in complex with 7 indicated that the sulfonamide oxygens, and not the sulfonamide -NH-, formed favorable interactions with the enzyme. Thus, we hypothesized that replacement of the sulfonamide -NH-with a methylene group could result in compounds that would retain potency at PNMT and that would have increased lipophilicity, thus increasing the likelihood they will cross the blood brain barrier. A series of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines (23-30) were synthesized and evaluated for their PNMT inhibitory potency and affinity for the R2-adrenoceptor. A comparison of these compounds with their isosteric sulfonamides (14, 16, and 18-22) showed that the sulfones were more lipophilic but less potent than their corresponding sulfonamides. Sulfone 24 (hPNMT K-i = 1.3 mu M) is the most potent compound in this series and is quite selective for PNMT versus the R2-adrenoceptor, but 24 is less potent than the corresponding sulfonamide, 16 (hPNMT K-i = 0.13 mu M). We also report the crystal structure of hPNMT in complex with sulfonamide 15, from which a potential hydrogen bond acceptor within the hPNMT active site has been identified, the main chain carbonyl oxygen of Asn39. The interaction of this residue with the sulfonamide -NH-is likely responsible for much of the enhanced inhibitory potency of the sulfonamides versus the sulfones.

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Esta pesquisa privilegia o enfoque histrico ao analisar o texto bblico, como produto histrico-social, a partir do mtodo sociolgico. O material disposto ao longo desta investigao pretende ser uma ajuda para a compreenso de alguns textos do profeta Jeremias. Partindo do princpio de que o texto possui um vnculo com a sociedade na qual foi criado e fazendo uso da metodologia exegtica, realiza-se uma anlise histrico-sociolgica da palavra de Jav em Jeremias 7,1 8,3 como portadora de um conflito social oriundo da cobrana excessiva de tributo em uma sociedade judata marcadamente tributria. Busca-se, por esse meio, o sentido do texto dentro do provvel cenrio histrico-social que permeia o escrito. Para isso, faz-se necessria a investigao dos aspectos preliminares que envolvem tanto o livro de Jeremias, sobretudo, os polmicos caps. 7,1 8,3, como tambm a questo do estudo da pesquisa moderna acerca dessa magnfica obra. Vale a pena tambm salientar o conceito semitico da potica sociolgica que procura estudar a interao causal entre literatura e seu meio social. Alm disso, avalia-se o mbito histrico social da unidade literria alvo de nossa pesquisa, situando-a em seu provvel contexto histrico social e determinando a datao, o cenrio poltico e o modo de produo vigente nesse perodo. No olvidando, contudo, do fator desencadeador do conflito social e o papel da religio nesse cenrio. Alm do mais, examina-se o sentido dos textos especficos ou unidades literrias concludas (percopes) presentes nos caps. 7,1 8,3, tendo como pressuposto o modelo terico do modo de produo tributrio e os passos da exegese histrico-social. O mecanismo socioanaltico do modo de produo tributrio servir como instrumento de anlise da condio socioeconmica, centrando-se nos componentes externos incorporados na coletnea, no em sua histria redacional, mas sim em sua formao social.

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Nesta dissertao nos propomos a fazer uma leitura da narrativa de Atos dos Apstolos 6,1-8,3, considerando-a nos moldes de uma antiga tradio de martrio. Os Helenistas entram em conflito com os Hebreus, Estevo entra em atrito com os judeus da dispora que se renem nas sinagogas, e levado perante o Sindrio e executado. O motivo de sua execuo a crtica Lei e ao Templo. Depois de ter uma experincia de xtase visionrio ele violentamente assassinado. Lucas, todavia, descreve Estevo como heri vitorioso. A realidade de conflitos, oposio, perseguio e martrio no se constitui em derrota, mas em fortalecimento da f. A morte de Estevo interpretada dentro desta tradio. A compreenso do caso de Estevo e dos Helenistas fundamental para entender a continuao do movimento dos seguidores de Jesus e o incio do desenvolvimento da Cristologia aps o evento pascal.(AU)

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The first syntheses of the natural products myo-inositol 1,2,3-trisphosphate and (+/-)-myo-inositol 1,2-bisphosphate are described. The protected key intermediates 4,5,6-tri-O-benzoyl-myo-inositol and (+/-)-3,4,5,6-tetra-O-benzyl-myo-inositol were phosphorylated with dibenzyl N,N-di-isopropylphosphoramidite in the presence of 1H-tetrazole and subsequent oxidation of the phosphite. The crystal structures of the synthetic intermediates (+/-)-1-O-(tert-butyldiphenylsilyl)-2,3,O-cyclohexylidene-myo-inos itol and (+/-)-4,5,6-tri-O-benzoyl-1-O-(tert-butyldiphenylsilyl)-2,3-O-cycl ohexylidene- myo-inositol are reported. myo-Inositol 1,2,3-trisphosphate (+/-)-myo-inositol 1,2-bisphosphate, and all isomeric myo-inositol tetrakisphosphates were evaluated for their ability to alter HO. production in the iron-catalysed Haber-Weiss reaction. The results demonstrated that a 1,2,3-grouping of phosphates in myo-inositol was necessary for inhibition also that (+/-)-myo-inositol 1,2-bisphosphate potentiated HO. production. myo-Inositol 1,2,3-trisphosphate resembled myo-inositol hexakisphosphate (phytic acid) in its ability to act as a siderophore by promoting iron-uptake into Pseudomonas aeruginosa.