975 resultados para Theo van Doesburg


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door August Rohling. Geheel herzien en verbeterd door Max. de Lamarque

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gemponeerd door A. Berlijn. De tekst bewerkt onder opzigt van G. I. Polak

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nieuwijx agtervolgd op de 2 stuk, eertijds uitgeg. door W[illem] Goeree

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In chronic lymphocytic leukemia (CLL) medical progress is driven by clinical studies with relapse-free survival (RFS) as the primary endpoint. The randomized EBMT-Intergroup trial compared high-dose therapy and autologous stem cell transplantation (ASCT) to observation and demonstrated a substantial improvement of RFS without showing improved overall survival for the transplant arm. Here we report quality of life (QoL) information of the first 3 years following randomization from that study. The main objective was to assess the impact of treatment on QoL over time. Two secondary analyses were performed to further investigate the impact of ASCT and relapse on QoL. In the primary analysis, we demonstrate an adverse impact of ASCT on QoL which was largest at 4 months and continued throughout the first year after randomization. Further, we demonstrated a sustained adverse impact of relapse on QoL which worsened over time. Despite better disease control by ASCT the side effects thus turned the net effect towards inferior QoL in the first year and comparable QoL in the following 2 years after randomization. This study emphasizes the importance of information concerning QoL impacts when patients are counseled about treatments aimed at improving RFS in the absence of a survival benefit.

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uit de deloofwaardigste bronnen bearb. door S. I. Mulder

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[Jac. Zwarts]

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door Menachem Man ben Salomo Halevi... uit het Joodsch-Duitsch vertaald door L. Goudsmit ... verrijkt door G. I. Polak