History of the manufacture of iron in all ages, and particularly in the United States from colonial time to 1891. Also a short history of early coal mining in the United States ...

Mode of access: Internet.

Check list of American Revolutionary War pamphlets in the Newberry Library /

Early editions and contemporary reprints of political pamphlets, American and English, 1750-1786.

A library of American literature from the earliest settlement to the present time,

Contents.--v. 1. Early colonial literature, 1607-1675.--v. 2. Later colonial literature, 1676-1764.--v. 3. Literature of the revolutionary period, 1765-1787.--v. 4. Literature of the republic, pt. 1, 1788-1820.--v. 5. Literature of the republic, pt. 2, 1821-1834.--v. 6-8. Literature of the republic, pt. 3, 1835-1860.--v. 9.-10. Literature of the republic, pt. 4, 1861-1888.--v. 11. Literature of the republic, pt. 4, 1861-1888 (continued) Additional selections, 1834-1889. Short biographies of all authors represented in this work, by Arthur Stedman. General index.

A library of American literature...

Contents.- v. 1. Early colonial literature, 1607-1675.- v. 2. Later colonial literature, 1676-1764.- v. 3. Literature of the revolutionary period, 1765-1787.- v. 4. Literature of the Republic. pt. 1. 1788-1820.- v. 5. Literature of the Republic. pt. 2. 1821-1834.- v. 6-8. Literature of the Republic. pt. 4, cont. 1861-1888.- v. 11. Literature of the Republic. pt. 4, cont. 1861-1889. Short biographies of all authors represented in this work, by Arthur Stedman. General index.

Falk ; Any Foster ; To-morrow : three stories /

Later printing of the first American edition of the 'other stories.' See Cagle, cited below.

Directory of short-horn breeders of the United States alphabetically arranged by states, 1905.

Mode of access: Internet.

Sargasso sea and other stories,

American edition has title: A woman of the Shee and other stories.

The foundations of American nationality,

Published in 1922 as volume I of "A short history of the American people."

"Sorrow Brought Forth Joy": Feelings of Faith in American Literature

Thesis (Ph.D.)--University of Washington, 2016-06

Mental Health Experiences within the Hmong American LGBTQ Community: A Qualitative Research Project

Thesis (Master's)--University of Washington, 2016-06

Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex

A growing body of evidence suggests that the Golgi complex contains an actin-based filament system. We have previously reported that one or more isoforms from the tropomyosin gene Tm5NM (also known as gamma-Tm), but not from either the alpha- or beta-Tm genes, are associated with Golgi-derived vesicles (Heimann et al., (1999). J. Biol. Chem. 274, 10743-10750). We now show that Tm5NM-2 is sorted specifically to the Golgi complex, whereas Tm5NM-1, which differs by a single alternatively spliced internal exon, is incorporated into stress fibers. Tm5NM-2 is localized to the Golgi complex consistently throughout the G1 phase of the cell cycle and it associates with Golgi membranes in a brefeldin A-sensitive and cytochalasin D-resistant manner. An actin antibody, which preferentially reacts with the ends of microfilaments, newly reveals a population of short actin filaments associated with the Golgi complex and particularly with Golgi-derived vesicles. Tm5NM-2 is also found on these short microfilaments. We conclude that an alternative splice choice can restrict the sorting of a tropomyosin isoform to short actin filaments associated with Golgi-derived vesicles. Our evidence points to a role for these Golgi-associated microfilaments in vesicle budding at the level of the Golgi complex.

Metal Clips Induce Folding of a Short Unstructured Peptide into an a-Helix via Turn Conformations in Water. Kinetic versus Thermodynamic Products

Short peptides corresponding to two to four a-helical turns of proteins are not thermodynamically stable helices in water. Unstructured octapeptide Ac-His1*-Ala2-Ala3-His4*-His5*-Glu6-Leu7-His8*-NH2 (1) reacts with two [Pd ((NH2)-N-15(CH2)(2) (NH2)-N-15)(NO3)(2)] in water to form a kinetically stable intermediate, [{Pden}(2)-{(1,4)(5,8)-peptide}](2), in which two 19-membered metallocyclic rings stabilize two peptide turns. Slow subsequent folding to a thermodynamically more stable two-turn a-helix drives the equilibrium to [{Pden}(2)-{(1,5)(4,8)-peptide}] (3), featuring two 22-membered rings. This transformation from unstructured peptide via turns to an a-helix suggests that metal clips might be useful probes for investigating peptide folding.

Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure

Postprandial hyperglycemia is implicated as a risk factor predisposing to vascular complications. This study was designed to assess recurrent short-term increases in glucose on markers of renal fibrogenesis. Human renal cortical fibroblasts were exposed to fluctuating short-term (2 h) increases to 15 mM D-glucose, three times a day over 72 h, on a background of 5 mM D-glucose. To determine whether observed changes were due to fluctuating osmolality, identical experiments were undertaken with cells exposed to L-glucose. Parallel experiments were performed in cells exposed to 5 mM D-glucose and constant exposure to either 15 or 7.5 mM D-glucose. Fluctuating D-glucose increased extracellular matrix, as measured by proline incorporation ( P < 0.05), collagen IV ( P < 0.005), and fibronectin production ( P < 0.001), in association with increased tissue inhibitor of matrix metalloproteinase (MMP) ( P < 0.05). Sustained exposure to 15 mM D-glucose increased fibronectin ( P < 0.001), in association with increased MMP-2 ( P = 0.01) and MMP-9 activity ( P < 0.05), suggestive of a protective effect on collagen matrix accumulation. Transforming growth factor-beta(1) (TGF-beta(1)) mRNA was increased after short-term (90 min) exposure to 15 mM glucose (P < 0.05) and after 24-h exposure to 7.5 mM ? ( P < 0.05). Normalization of TGF-beta(1) secretion occurred within 48 h of constant exposure to an elevated glucose. Fluctuating L-glucose also induced TGF-beta(1) mRNA and a profibrotic profile, however, to a lesser extent than observed with exposure to fluctuating D-glucose. The results suggest that exposure to fluctuating glucose concentrations increases renal interstitial fibrosis compared with stable elevations in D-glucose. The effects are, in part, due to the inherent osmotic changes.