Vereda and Murundu wetlands and changes in Brazilian environmental laws: challenges to conservation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Nanotechnology-based drug delivery systems for melanoma antitumoral therapy: a review

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Games independentes: plataformas de inovação das novas mídias no contexto da economia criativa

Creative spaces need freedom. Any productions, especially with artistic content, need space to mistakes, that is, for an attempt away from the standard. The independent production environment is recognized in different artistic sectors as a space for innovation, to be free of the serial production logic. The major innovations in the international scenario of games came from the independent productions. Great classics revolutionized the aesthetics and functionality of this new media. This project aims to analyze the productive chains of Brazilian independent games, starting with a regional analysis. The goal is to observe the factors responsible for the innovation that these games can offer, the management aspects of creative processes, articulation of innovative agents and resources mobilized. Brazil currently has the fourth largest gaming market in the world with expectation of strong growth for years to come, but arises in the international market as a consumer. Given this regional demand is necessary to study the tools of production, even to help fill that need. Not only the production of games should be thought, the media coverage is also another important factor, in view of the economic importance of this segment. Understanding the mechanisms of innovation in the gaming universe, its impact on the formation of public and coverage of specialized journalism in this new media are possible outcomes of future studies and research that scientific research can contribute

Análise da suscetibilidade a corridas de massa aplicada a dutovias: estudo de caso na bacia do Ribeirão do Roque

This scientific research aimed at to analyse the susceptibility to debris flow of the watershed of Ribeirão do Roque (SP), focusing on the upstream areas of OSBRA pipeline. This is because, mass flow can cause damage to pipes, mainly due to conditioning hydro erosion of the land in the drainage crossings, including the undermining the banks of streams. Firstly, It was conducted a literature review, aiming to identify and understand the principal characteristics and conditions of debris flow. Secondly, the physical and anthropic factors and their respective weights of influence were selected and used to determine the mass flow susceptibility. It was selected the following physical factors: type and thickness of rocks, soil and unconsolidated materials; textural density; amplitude relief; relief slope; shaped valley; and shape of slopes. Such factors are present in the physiographic subdivision map of the study area. In addition, the anthropic attributes correspond to the classes contained in the land use map. Therefore, the physical and anthropic factors were integrated through the multi-criteria analysis in a GIS environment, generating a total susceptibility map of debris flow on the scale 1:50,000. The results showed that a significative part of the study area was classified as average susceptibility. However, it was identified areas with high susceptibility in the region in which the pipe cross the Ribeirão do Roque. Moreover, at which point the river presents a closed valley and a meander shape, without a fluvial plain that would be useful to attenuate the development of the process. Consequently, if a mass flow begins in any of these most susceptible regions located upstream of the pipe, the chances that the process develops by the river and causes the excavations of his bed are quite large. However, the pipelines cross these critical areas directly on the rock (diabase), which provides additional protection against possible ...

Lean construction como estratégia para melhorias em canteiros de obras: uma revisão sistemática na literatura nacional

Pós-graduação em Engenharia de Produção - FEB

Raising of horn fly haematobia irritans (L.) (diptera: muscidae) in laboratory by means of egg and larva inoculation

Several studies have required Haematobia irritans (L.) raising in laboratory. The present study assessed two methods of inoculating immature forms of H. irritans to obtain adults. In 2007, 15 Nellore steers (Bos indicus) (L.) were used for the collection of feces free of anthelmintic treatment and flies to produce for eggs and larva. For method I, 30 eggs were incubated in square filter paper (5 × 5 cm) and deposited on bovine feces (500 g) where they were kept until hatching and spontaneous penetration of larvae (L1) into the fecal mass. After 24 h, eggs were analyzed under a stereoscope microscope (40×) for the number of larvae that instinctively penetrated the feces. In method II, larvae were obtained only by natural egg hatching. At birth, 30 larvae were collected and individually inoculated, directly onto the fecal plate by employing a moistened brush. The tests were carried out at controlled temperature (28˚C ± 2˚C) and saturated humidity (80%) until the emergence of flies with both methods. The number of emerged flies was considered in the result. Using method I, 276 (76.7%) flies emerged from 360 inoculated eggs, while using method II, 283 (78.6%) flies emerged from 360 inoculated larvae. There was no significant difference (P = 0.7821) between methods for the number of flies; however, the proportion between males and females by means of larva inoculation was different from 1:1 (P = 0.0146). Results indicated that both methods led to a satisfactory production of flies and egg inoculation provided an easier establishment.

Uranium metabolism associated with ontogenetic growth of birds: case studies with broilers and ducks

Cobb broilers and domestic ducks, both one-day-old, were treated using ration doped with 20 ppm of uranyl nitrate. Uranium concentrations in the tibia (μg-U/g-bone) were measured by neutron activation analysis as function of the animals’ age, from the neonatal period to maturity. Results show that Uranium and Calcium qualitatively follow the same metabolic pathway, and that adult ducks incorporate on average ten times more Uranium than broilers. Data interpretation shows that the Uranium clearance rate in broilers is substantially higher than that in ducks, suggesting that metabolic characteristics favoring Calcium retention in bone may hinder the elimination of Uranium in ducks. The need for further comparative biochemistry studies between Galliformes and Anseriformes is addressed.

Sintomas auditivos e desordens temporomandibulares

Introduction: A variety of hypotheses have been proposed to explain the association between temporomandibular disorders and hearing symptoms, including the many anatomical and/or neurological ways, as of a muscle or joint dysfunction, can cause such symptoms. Objective: The purpose of this study is to discuss, through a systematic review of literature, the interrelation between hearing symptoms and temporomandibular disorders. Material and Methods: We consulted the Medline/PubMed, ISI and Scielo in the period 1918 to 2008. The terms related to the research were: “temporomandibular disorders”, “signs and symptoms of temporomandibular disorders”, “otologic symptoms” and “aural symptoms”, where 19 papers were included using the pre-selected criteria for the manufacture of a meta-analysis. Results: According to the findings, the hearing symptoms most often associated with temporomandibular disorders were otalgia and tinnitus, followed by vertigo and hearing loss, respectively. Conclusions: It’s clear the correlation between hearing symptoms and temporomandibular disorders, however there is a need clinical and scientific research more complex to prove the specific cause-effect relationships between them.

Atividade antimicrobiana de cimentos endodônticos

The antimicrobial activity is a fundamental property of root-canal sealers due to persistence of residual microorganisms in the root canal system, even after the chemo-mechanical preparation and using of intracanal dressing. The aim of this study is to review the literature about the antimicrobial properties of some of the main root-canal sealers. Although there is controversy regarding this property, probably due to differences in the methodologies used in the studies, it was concluded that the sealers with the best antimicrobial activity were (in ascending order): Endofill, Ketac Endo, Sealapex, AH Plus, Endo CPM Sealer, Sealer 26 and Epiphany. Activ GP still needs scientific research to evaluate this property.

Performance characteristics of UV and visible spectrophotometry methods for quantitative determination norfloxacin in tablets

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Expression of α6 integrin subunit in bovine oocyte and its potential role during fertilization

Fertilization in mammals requires the successful completion of a sequence of steps, starting with the transport of gametes in the reproductive tract and ending with sperm-egg membrane fusion to produce a zygote. Although some integrin subunits are known to be associated with the plasma membrane of some mammalian oocytes and spermatozoa, the presence of α6 integrin on bovine oocytes with intact zona pellucida has not been reported. The present study was undertaken to evaluate the expression of α6 integrin subunit in bovine oocyte and to determine if in vitro binding to the zona pellucida and fertilization were affected by treating oocytes with α6 integrin subunit antibody. The α6 integrin subunit was identified on the bovine oocyte by immunocytochemistry. In vitro fertilization was significantly decreased when in vitro matured bovine oocytes were pre-incubated with α6 integrin subunit antibody at concentration 5 and 20 μg/mL, and spermoocyte binding increased. These studies demonstrated the presence of α6 integrin subunit on bovine oocyte, and its importance in fertilization and polyspermy.

Development and validation of an LC-MS/MS method for quantitative analysis of mirtazapine in human plasma

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Validation of a HPLC method for determination of glutamine in food additives using post-column derivatization

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Plantas medicinais: indicação popular de uso no tratamento de hipertensão arterial sistêmica (HAS)

The aim of this study is to investigate the spontaneous use of medicinal plants by volunteer patients in the treatment of hypertension and to determine the most used plants in this situation. Data were collected through a questionnaire and a semi-structured guided interview applied to patients from a health center in the Midwest region of the state of Sao Paulo, Brazil. Quantitative analysis identified a high number of hypertensive patients spontaneously using herbal treatment. The referred plants were identified by the Herbarium Botu and researched in the literature as to their therapeutic actions. The biggest mistake was observed in the misuse of the Bilberry for the treatment of hypertension, which reveals that health professionals and the community in general should be more careful. As a result we have published an informative booklet, with emphasis on hypertension concepts and on the use of medicinal plants as an alternative therapy method for this disease in order to provide scientific knowledge and scientific research evidence to this practice.

Educação física escolar: estado da arte e direções futuras

The aim of this paper is to characterize and discuss the School Physical Education as a profession and subarea of research in the broader academic fi eld of Physical Education and educational research. To do that, it initially defi nes the difference between research in School Physical Education from research about School Physical Education, and point out the themes and research hypotheses for this subarea. It also analyses 289 articles characterized as research in School Physical Education, published in 11 Brazilian periodicals, classifying them in the following categories: “level of schooling”, “bodily practice” and “theme”. The results indicate that the majority of studies are carried out in elementary school, in “games” and “sports”, and in descriptive and interpretative research in School Physical Education practices in several dimensions and interrelations. In conclusion, it points to the need to a focus in the research in teaching, the implementation of public curricula, and teacher education. Finally, it alerts to the need for Brazilian postgraduate programs in the academic fi eld of physical education to invest more in research in School Physical Education subarea.