Qvae svnt caesaris caesari: uma proposta de leitura dos Commentarii de Bello Gallico

Pós-graduação em Linguística e Língua Portuguesa - FCLAR

Confluências entre mito, literatura e direito em Édipo Rei, de Sófocles

Pós-graduação em Letras - IBILCE

Os caminhos movediços de Bandeira

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O duplo na perspectiva da literatura fantástica nos contos de Cristina Fernández Cubas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Macário e La cruz del diablo: a caracterização da figura do diabo na literatura fantástica

Pós-graduação em Letras - IBILCE

Um pássaro invocou mudamente o abismo: tensão entre as categorias positivas e negativas na poética de Orides Fontela

Pós-graduação em Letras - IBILCE

Women from the point of view of the Bukowskian narrator: the representation of the feminine universe in Erections, Ejaculations, Exhibitions and General Tales of Ordinary Madness

Pós-graduação em Letras - IBILCE

The aesthetic movement in Oscar Wilde's plays

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Um estudo da adaptação cinematográfica da figura do herói do romance Stardust, de Neil Gaiman

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Lima Barreto: O Brasil sob a ótica do Dr. Bogóloff

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

De poeta a editor de poesia: a trajetória de Machado de Assis para a formação de suas Poesias completas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Em busca do tempo perdido de Marcel Proust recriado em quadrinhos: o narrador de No caminho de Swann adaptado para narrativas gráficas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Em busca do tempo perdido de Marcel Proust recriado em quadrinhos: o narrador de No caminho de Swann adaptado para narrativas gráficas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Synthesis and characterization of the atropisomeric relationships of a substituted N-phenyl-bipyrazole derivative with anti-inflammatory properties

This work describes the atropisomeric relationships of 3-methyl-5-(3-methyl-5-phenyl-1H-pyrazol-1-yl)-1-phenyl-1H-pyrazol-4-amine (2d), which belongs to series 4-aminobipyrazole derivatives designed as anti-inflammatory agents. The 1H nuclear magnetic resonance spectra obtained in the presence of a chiral lanthanide shift salt associated to chiral high-performance liquid chromatography analysis, X-ray diffraction, and molecular modeling tools confirmed that ortho bis-functionalized bipyrazole 2d exists as a mixture of aR,aS-atropisomers. These results provide useful information to understand the pharmacological profile of this derivative and of other 4-aminobipyrazole analogs. Chirality 24:463470, 2012. (c) 2012 Wiley Periodicals, Inc.

Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors

p38 mitogen-activated protein kinase (p38 MAPK) is an important signal transducing enzyme involved in many cellular regulations, including signaling pathways, pain and inflammation. Several p38 MAPK inhibitors have been developed as drug candidates to treatment of autoimmune disorders, such as rheumatoid arthritis. In this paper we reported the docking, synthesis and pharmacological activity of novel urea-derivatives (4a-e) designed as p38 MAPK inhibitors. These derivatives presented good theoretical affinity to the target p38 MAPK, standing out compound 4e (LASSBio-998), which showed a better score value compared to the prototype GK-00687. This compound was able to reduce in vitro TNF-alpha production and was orally active in a hypernociceptive murine model sensible to p38 MAPK inhibitors. Otherwise, compound 4e presented a dose-dependent analgesic effect in a model of antigen (mBSA)-induced arthritis and anti-inflammatory profile in carrageenan induced paw edema, indicating its potential as a new antiarthritis prototype. (c) 2012 Elsevier Masson SAS. All rights reserved.