2006 Ice Hockey Team

Back Row: Rick Bancroft, Athletic Trainer; Tom Kahila, Assistant Equipment Manager; L.J. Scarpace, Video Coordinator; Matt Martinez, Assistant Equipment Manager; Ian Hume, Equipment Manager; Josh Richelew, Director of Hockey Operations.

Third Row: Morgan Ward; Danny Fardig; Travis Turnbull; Tim Miller; David Rohlfs; Tim Cook; Mark Mitera; Zac MacVoy; Brandon Naurato; Adam Dunlap.

Second Row: Chris Fragner; Mike Mayhew; Chad Kolarik; Jason Bailey; Jack Johnson; Jason Dest; Kevin Porter; Andrew Cogliano; Tyler Swystun; Jon Montville.

Front Row: Mel Pearson, Associate Head Coach; Billy Sauer; Matt Hunwick; Brandon Kaleniecki; Red Berenson, Head Coach; Andrew Ebbett; T.J. Hensick; Noah Ruden; Billy Powers, Assistant Coach.

1973 UM Track Team

Top Row: head coach Dixon Farmer, Jon Cross, Terry Hart, Mark Bohlke, Ed Kulka, Steve Fenster, Doug Gibbs, trainer Len Paddock, Mike Nowacki, Jesse Myers, George Przygodski, Will Saunders, Abe Butler, Dave Mogk, asst. coach Jack Harvey, asst. coach George Wade.

2nd Row: Bill Bolster, George Gilchrest, Pete Hill, Rick Schott, Mike Lantry, Steve Adams, Kim Rowe, Bob Mills, Bill Heth, Jim Howe, Mel Reeves

Front Row: asst. st. mngr. Mike D'Agostino, Al Cornwell, Eric Chapman, Greg Syphax, Vern Rottman, Godfrey Murray, st. mngr. Joe Abraham

2007 Men's Gymnastics Team

Back Row: Andrew Elkind, Arren Yoshimura, John Sawicki, Paul Woodward, Ryan McCarthy, Daniel Rais, Aaron Rakes, Justin Laury, Mel Santander

Middle Row: Torrance Laury, Phil Goldberg, Jamie Thompson, Bruno Savard, Joe Levine, Kent Caldwell, Josh Miele, Ralph Rosso, Scott Bergman, Joe Catambrone

Front Row: head trainer Bill Shinavier, assistant coach Scott Vetere, head coach Kurt Golder, assistant coach Xiao Yuan. volunteer assistant coach Derek Croad, student athletic trainer Navid Hannanvash, student athletic trainer Liz Sibilsky

Partnership in the arts : public and private support of cultural activities in the San Francisco Bay area /

Mode of access: Internet.

Masonstvo v ego proshlom i nastoi︠a︡shchem.

List of illus. also in French.

Vospominanīi︠a︡ o t︠s︡arskoĭ semʹi︠e︡ i ei︠a︡ zhizni do i posli︠e︡ revoli︠u︡t︠s︡īi.

At head of title: Tatʹi︠a︠na Melʹnik (rozhdennai︠a︡ Botkina)

An evaluation of the training provided in correctional institutions under the Manpower development and training act, section 251; final report.

Report MEL 71-09a-c.

An evaluation of results and effectiveness of job banks /

"Contract no. 83-06-72-01."

Antiproliferative and phenotype-transforming antitumor agents derived from cysteine

Selective destruction of malignant tumor cells without damaging normal cells is an important goal for cancer chemotherapy in the 21st century. Differentiating agents that transform cancer cells to either a nonproliferating or normal phenotype could potentially be tissue-specific and avoid side effects of current drugs. However, most compounds that are presently known to differentiate cancer cells are histone deacetylase inhibitors that are of low potency or suffer from low bioavailability, rapid metabolism, reversible differentiation, and nonselectivity for cancer cells over normal cells. Here we describe 36 nonpeptidic compounds derived from a simple cysteine scaffold, fused at the C-terminus to benzylamine, at the N-terminus to a small library of carboxylic acids, and at the S-terminus to 4-butanoyl hydroxamate. Six compounds were cytotoxic at nanomolar concentrations against a particularly aggressive human melanoma cell line (MM96L), four compounds showed selectivities of greater than or equal to5:1 for human melanoma over normal human cells (NFF), and four of the most potent compounds were further tested and found to be cytotoxic for six other human cancer cell lines (melanomas SK-MEL-28, DO4; prostate DU145; breast MCF-7; ovarian JAM, CI80-13S). The most active compounds typically caused hyperacetylation of histones, induced p21 expression, and reverted phenotype of surviving tumor cells to a normal morphology. Only one compound was given orally at 5 mg/kg to healthy rats to look for bioavailaiblity, and it showed reasonably high levels in plasma (C-max 6 mug/mL, T-max 15 min) for at least 4 h. Results are sufficiently promising to support further work on refining this and related classes of compounds to an orally active, more tumor-selective, antitumor drug.

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gene encoding insulin-degrading enzyme (IDE) harbors sequence variants that associate with Alzheimer disease (AD). Evidence also indicated effects upon a number of quantitative indices of AD severity, including age-at-onset (AAO). Since linkage of this immediate region to AAO has been shown in both AD and Parkinson disease (PD), we have explored the possibility that polymorphism within this LD block might also influence PD. Utilizing single nucleotide polymorphisms that delineate common haplotypes from this region, we observed significant evidence of association with AAO in an Australian PD case-control sample. Analyses were complemented with AAO data from two independent Swedish AD case samples, for which previously reported findings were replicated. Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner.

Chronic hepatitis B: A critical appraisal of current approaches to therapy

Background & Aims: Treatment of chronic hepatitis B (CHB) involves a number of complex and controversial issues. Expert opinions may differ from those of practicing hepatologists and gastroenterologists. We aimed to explore this issue further after a critical review of the literature. Methods: A panel of 14 international experts graded the strength of evidence for 16 statements addressing 3 content areas: patient selection, therapeutic end points, and treatment options. Available data relating to the statements were reviewed critically in 3 small work groups. After discussion of each statement with the entire panel, the experts voted anonymously to accept or reject statements based on the strength of evidence and their experience. A total of 241 members of the American Association for the Study of Liver Diseases (AASLD) responded to the same statements and their responses were compared with those of the experts. A discordant response was defined as a difference of more than 20% in any of the 5 graded levels of response (accept or reject) between the 2 groups. Results: With the exception of 2 statements, the experts’ responses were relatively uniform. However, the responses of the AASLD members were discordant from the experts in 12 statements, spanning all 3 content areas. Conclusions: Several areas of disagreement on the management of CHB exist between experts and AASLD members. Our results indicate a potential knowledge gap among practicing hepatologists. Better educational efforts are needed to meet the challenge of managing this complex disorder in which even expert opinion occasionally may disagree.

Accent Recognition for Noisy Audio Signals

It is well established that accent recognition can be as accurate as up to 95% when the signals are noise-free, using feature extraction techniques such as mel-frequency cepstral coefficients and binary classifiers such as discriminant analysis, support vector machine and k-nearest neighbors. In this paper, we demonstrate that the predictive performance can be reduced by as much as 15% when the signals are noisy. Specifically, in this paper we perturb the signals with different levels of white noise, and as the noise become stronger, the out-of-sample predictive performance deteriorates from 95% to 80%, although the in-sample prediction gives overly-optimistic results. ACM Computing Classification System (1998): C.3, C.5.1, H.1.2, H.2.4., G.3.

Volt-e likviditási válság? Volatilitás és likviditás kapcsolatának vizsgálata (Was there a liquidity crisis? Analysis the relationship between volatility and liquidity)

Széleskörűen alátámasztott, empirikus tény, hogy önmagában a nagyobb volatilitás csökkenti a piac likviditását, vagyis változékonyabb piacokon várhatóan nagyobb lesz egy-egy tranzakció áreltérítő hatása. Kutatásomban azt a kérdést vizsgáltam, hogy a Budapesti Értéktőzsdén az OTP-részvény piacán a 2007/2008-as válságban tapasztalható, átmeneti likviditáscsökkenés betudható volt-e egyszerűen a megnövekedett volatilitásnak, vagy ezen túl abban más tényezők (pl. a szereplők körének és viselkedésének drasztikus megváltozása, általános forráscsökkenés stb.) is szerepet játszhattak-e. A volatilitást a loghozamok szórásával, illetve a tényleges ársávval, míg az illikviditást a Budapesti Likviditási Mértékkel (BLM) reprezentáltam. Egyrészt azt állapítottam meg, hogy az OTP esetében a tényleges ársáv szorosabban korrelál a BLM-mel, mint a szórás. Másrészt az is egyértelmű, hogy a válság előtti kapcsolat a volatilitás és a likviditás között a válságban és azután már jelentősen megváltozott. Válságban az illikviditás jóval nagyobb volt, mint amit a volatilitás növekedése alapján vártunk, a válság lecsengése után azonban megfordult ez a reláció. _________ It is a widely supported empirical fact, that the greater volatility in itself decreases the liquidity of the market, namely more volatile a market is, the higher a transaction’s price impact will be. I have examined in my paper the question, whether the decrease of liquidity during the crisis of 2007/2008 in case of the OTP stock – traded on the Budapest Stock Exchange – was the consequence of the increased volatility, or other factors had an effect on the illiquidity as well (e.g.: the drastic change of market participants’ behaviour; reduction of fi nancing sources; etc.). I have represented volatility with the standard deviation of the logreturns, and with the true range, while the illiquidity with the Budapest Liquidity Measure (BLM). On one hand I have identifi ed, that in case of the OTP, the true range has a stronger relationship with the BLM than the standard deviation has. On the other hand it was clear, that the relationship between volatility and liquidity has changed notably during and after the crisis. During crisis the illiquidity was greater than what I have estimated based on the volatility increase, but after the crisis this relation has changed.

A CRM hazai gyakorlatának feltáró elemzése

A CRM-elnevezés alig két évtizeddel ezelőtt vált általánossá a marketing köznyelvben. Az azóta eltelt időszakban azonban óriási mértékű fejlődés ment végbe ezen a területen, elsősorban a beszállítói oldalon. A CRM technológiai, informatikai oldalát képviselő partnerek és az alkalmazásokat üzleti szemszögből értelmező tanácsadók egyre inkább összehangolódtak, és komplex, integrált rendszereket képesek ajánlani a vállalatoknak. A felhasználói oldalon azonban nem ennyire egyértelmű a kép. A CRM adaptálása a vállalatok által alkalmazott, szerteágazó eszközrendszerbe nem mindig egyértelmű, és ezekre eltérő gyakorlati megoldások születnek. A tanulmány arra törekszik, hogy feltárja azokat a faktorokat, amelyek a fent említett divergenciát okozzák, megértse azok hatásmechanizmusait és kísérletet tegyen olyan mintázatok kialakítására, amelyek jól leírják egy egyes vállalatcsoportok viszonyát a CRM-mel. A kutatás 20 feltáró interjúra épül, amely öt iparág Magyarországon (is) működő vállalatainak CRM-felelőseivel készült. Az eredmények azt jelzik, hogy a CRM vállalati gyakorlata mögött mind iparági, mind vállalati sajátosságok is megjelenhetnek, egyben számos fejlesztési lehetőség adódik a CRM eredményesebb felhasználása érdekében.

Water temperature reconstructions based on paired Uk'37 and Tex86 records, and paired surface and subsurface Mg/Ca records

This dataset contains the collection of available published paired Uk'37 and Tex86 records spanning multi-millennial to multi-million year time scales, as well as a collection of Mg/Ca-derived temperatures measured in parallel on surface and subsurface dwelling foraminifera, both used in the analyses of Ho and Laepple, Nature Geoscience 2016. As the signal-to-noise ratios of proxy-derived Holocene temperatures are relatively low, we selected records that contain at least the last deglaciation (oldest sample >18kyr BP).