A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increased ovulation rate and prolificacy in homozygous sheep

P>Brazilian Santa Ines (SI) sheep are very well-adapted to the tropical conditions of Brazil and are an important source of animal protein. A high rate of twin births was reported in some SI flocks. Growth and Differentiation Factor 9 (GDF9) and Bone Morphogenetic Protein 15 (BMP15) are the first two genes expressed by the oocyte to be associated with an increased ovulation rate in sheep. All GDF9 and BMP15 variants characterized, until now, present the same phenotype: the heterozygote ewes have an increased ovulation rate and the mutated homozygotes are sterile. In this study, we have found a new allele of GDF9, named FecGE (Embrapa), which leads to a substitution of a phenylalanine with a cysteine in a conservative position of the mature peptide. Homozygote ewes presenting the FecGE allele have shown an increase in their ovulation rate (82%) and prolificacy (58%). This new phenotype can be very useful in better understanding the genetic control of follicular development; the mechanisms involved in the control of ovulation rate in mammals; and for the improvement of sheep production.

Longitudinal excursion and strain in the median nerve during novel nerve gliding exercises for carpal tunnel syndrome

Nerve and tendon gliding exercises are advocated in the conservative and postoperative management of carpal tunnel syndrome (CTS). However, traditionally advocated exercises elongate the nerve bedding substantially, which may induce a potentially deleterious strain in the median nerve with the risk of symptom exacerbation in some patients and reduced benefits from nerve gliding. This study aimed to evaluate various nerve gliding exercises, including novel techniques that aim to slide the nerve through the carpal tunnel while minimizing strain (sliding techniques). With these sliding techniques, it is assumed that an increase in nerve strain due to nerve bed elongation at one joint (e.g., wrist extension) is simultaneously counterbalanced by a decrease in nerve bed length at an adjacent joint (e.g., elbow flexion). Excursion and strain in the median nerve at the wrist were measured with a digital calliper and miniature strain gauge in six human cadavers during six mobilization techniques. The sliding technique resulted in an excursion of 12.4 mm, which was 30% larger than any other technique (p 0.0002). Strain also differed between techniques (p 0.00001), with minimal peak values for the sliding technique. Nerve gliding associated with wrist movements can be considerably increased and nerve strain substantially reduced by simultaneously moving neighboring joints. These novel nerve sliding techniques are biologically plausible exercises for CTS that deserve further clinical evaluation. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:972-980, 2007

Ky visit

Police cordon on Brisbane street during visit of former South Vietnamese vice president Nguyen Cao Ky to Australia in January 1967.

Demonstrations during Marshall Ky's visit to Brisbane, Australia in 1967

Demonstrations during visit of former South Vietnamese vice president Nguyen Cao Ky to Australia in January 1967.

Ky's visit - do gifts justify more conscripts?

Woman with placard during visit of former South Vietnamese vice president Nguyen Cao Ky to Brisbane, Australia in January 1967.

Go home fascist

Girls with placard during visit of former South Vietnamese vice president Nguyen Cao Ky to Brisbane, Australia in January 1967. Placard reads Go home fascist

Go home fascist 2

Girl with placard Go home fascist during visit of former South Vietnamese vice president Nguyen Cao Ky to Brisbane, Australia in January 1967.

Police during Ky visit

Police and demonstrators during visit of former South Vietnamese vice president Nguyen Cao Ky to Brisbane, Australia in January 1967. One of the policemen possibly John O'Gorman?

Crowd scene during Ky visit to Brisbane

Crowd scene during visit of former South Vietnamese vice president Nguyen Cao Ky to Brisbane, Australia in January 1967.

Hec (Hector) Chalmers speaking to newsmen during Ky visit

Hec (Hector) Chalmers speaking to newsment during visit of former South Vietnamese vice president Nguyen Cao Ky to Brisbane, Australia in January 1967.

Women during Aldermaston Peace march 1965

Women with placards and banners during Aldermaston Peace march 1965. The march covered the distance between Ipswich and Brisbane, Australia, walked in relays covering approximately two miles each. Most relay sections were sponsored by one or more individual organisations.

Placard on truck during Labour Day procession Brisbane 1966

Placard "Brisbane 1966 not Germany 1936" on truck during Labour Day procession Brisbane 1966. Image shows arrest of student during anti war demonstration in Brisbane, Australia, 1966. City Hall tower can be seen in background.

Conscription banner on truck during Labour Day procession 1966 Brisbane

Conscription headstone banner on truck during Labour Day procession 1966 Brisbane, Australia.

Aussie don't be led by the nose - withdraw troops from Vietnam

Two men on back of Vanguard utility during Labour Day procession 1966, Brisbane, Australia. One is dressed as Uncle Sam. He is leading the other by the nose. The second man is dressed as an Australian soldier. Placards on utility read "Don't be led by the nose - withdraw troops from Vietnam".

Peace march 1964 Brisbane Australia

Marchers during the 1964 peace march, Brisbane, Australia, holding banners and placards