La casa en imágenes : pulsos, ecos y huellas del habitar contemporáneo

La imagen fotográfica es un bloque espacio tiempo congelado, un fragmento referido al antes y el después de algo. Al contemplar una fotografía de un interior doméstico, descubrimos un entretejido sutil entre el habitante y su hábitat. Somos capaces de recaer en más detalles de los que el ojo humano puede apreciar en su visión cotidiana, siempre ligada al devenir espacio temporal. El acto de fotografiar el hogar, de congelar unidades habitadas infinitesimales, se revela como una manifestación radical del modo unipersonal de habitar de cada fotógrafo, profesional o aficionado, y por extensión, dado que hoy todos somos fotógrafos; de cada habitante. Por un lado, la fotografía se piensa aquí como herramienta, capaz de desvelar, de poner en el mundo, los elementos, percepciones y acontecimientos, que subyacen imbricados en la construcción del hogar. Por otro, la imagen se entiende como medio de expresión y de comunicación, como el lenguaje universal de nuestro tiempo, por todos conocido y utilizado. En este momento de interconexión máxima, entre redes, datos y capas de cognición, de velocidad y aceleración, esta tesis doctoral se plantea como una vuelta a la reflexión, a la contemplación del objeto imagen, desde la certeza de que para que ésta hable hay que darle tiempo. Así, la investigación hay que entenderla desde una base ontológica y fenomenológica; desde la experiencia del ser que habita un entorno concreto y determinado. Se enmarca en el actual entorno socio cultural de occidente, se busca desvelar el significado y modo de habitar del habitante común, poniendo de manifiesto aquello que acontece para que una casa cualquiera, de un habitante cualquiera, devenga hogar. Los primeros indicios sobre el tema surgirán del análisis y la reinterpretación hermenéutica de un atlas de imágenes del habitar: cuerpo de imágenes reunido a partir de series fotográficas de hogares, de habitantes anónimos, puestos a luz por la mirada de un grupo de artistas. Posteriormente, ponemos a prueba el conocimiento adquirido en el análisis anterior, mientras que expandimos la investigación hacia el sentir del habitante común, mediante la realización de tres experimentos participativos, o estudios de campo cualitativos. Los resultados, de ambos grupos de casos de estudio, se compilan, organizan y estructuran en una taxonomía del habitar. Esta taxonomía está compuesta por cuarenta y siete parámetros, que explicitan la naturaleza compleja del hogar del siglo XXI. Este hogar es entendido como un constructo personal de cada habitante, un proceso que acontece en el tiempo y en el espacio, y que entraña la propia construcción del habitante. Esta extensa taxonomía se organiza según tres ámbitos del ser humano, en el primero se expresan los factores relacionados con el modo de "estar físicamente" en el hogar, incluyendo: al propio habitante, la casa como espacio arquitectónico y como materialidad: objetos, muebles, iconos y símbolos que pueblan el hogar. En segundo lugar, se manifiestan los parámetros relacionados con el modo de “percibir”: por un lado, aquello que se deriva de lo que se ve, y por otro, lo que se deriva de aquello que no se ve, pero se siente. En tercer lugar, se explicitan los factores relativos al habitante que "crea/juega" su hogar, quién por un lado, es en el mundo actuando, y que por otro, siente el mundo construyéndolo mediante una serie de relaciones que establece con él. Finalmente, la investigación intenta revelar las sinergias, conexiones y relaciones, entre todos estos elementos extraídos del sentir del habitante común, y que fueron inducidos mediante el análisis y reinterpretación de los casos de estudio, poniendo de manifiesto un orden de cosas en el habitar occidental contemporáneo. ABSTRACT The photographic image is a frozen space time block, a fragment referred to a something before and after. When we stare at the photography of domestic interiors we discover a subtle interweaving between the inhabitant and her habitat. We are able to acknowledge infinite more details than the human eye, in its continuous quotidian vision always linked to the space time progression, appreciates. The act of photographing the home, of freezing infinitesimal inhabited units, reveals as a radical statement of the concept of inhabiting for each photographer, professional or amateur, and by extension, as we today all are photographers, for each inhabitant. On the one hand, photography is here conceived as a tool that is capable of revealing, "of placing in the world" the elements, perceptions and happenings that underlie imbricated in the construction of a home. On the other hand, image is thought as an expression and communication media, as the universal language of our time (as far as it is known and used by all of us). In this precise moment of maximum interconnection between networks, data and cognitive layers; of speed and acceleration, this PhD Dissertation is conceived as a return to reflection; to the contemplation of object image, from the certainty of its need of time for talking. Therefore, this research from an ontological and phenomenological base; from the experience of the self who inhabits a determined and concrete environment, that of the western countries at the present, pursues to unveil the meaning and way of inhabiting of a common dweller and manifest what conforms the transformation of any house, of any inhabitant into a home. The first clues will arise from the analysis and hermeneutical reinterpretation of the Atlas of inhabiting; an assembled body of images of anonymous inhabitants houses, brought into life through a group of artist´s glance. Afterwards, we will test the analysis´s acquired knowledge, while extending the investigation to the feel of the common inhabitant (and no longer the expert^ artist) through the execution of three participative experiments conceived as qualitative field works. The results of both case study groups, will be compiled, organized and structured in a taxonomy of the inhabiting. This taxonomy is composed by forty seven parameters that explicitly state the complex nature of the XXI century home, regarded as a personal construct of every single inhabitant, as a process that happens through time and space and that entails the construction of the inhabitant. This wide taxonomy is organized regarding three spheres of the human being, In first place, those elements related to the way of “physically being” at home are expressed, including: the inhabitant its self, the house as architectural space and as materiality: objects, furniture, icons and symbols that fill the home. In second place, parameters related to the way of “perceiving“ are manifested; on the one hand, those that derive from what we see; on the other hand, those that derive from what we do not see, but feel. In third place, those factors deriving from the inhabitant as a home "creator/player" who is acting in the world and feeling the world while constructing it through a myriad of relationships he establishes with it. Finally, the investigation tries to reveal the synergies, connections and relations between all these elements extracted from the feelings of the common inhabitant, induced through the analysis and reinterpretation of the case studies, and therefore exposing a state of things belonging to western world at present.

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

Bruton’s tyrosine kinase (Btk) is essential for normal B lymphocyte development and function. The activity of Btk is partially regulated by transphosphorylation within its kinase domain by Src family kinases at residue Tyr-551 and subsequent autophosphorylation at Tyr-223. Activation correlates with Btk association with cellular membranes. Based on specific loss of function mutations, the Btk pleckstrin homology (PH) domain plays an essential role in this activation process. The Btk PH domain can bind in vitro to several lipid end products of the phosphatidylinositol 3-kinase (PI 3-kinase) family including phosphatidylinositol 3,4,5-trisphosphate. Activation of Btk as monitored by elevation of phosphotyrosine content and a cellular transformation response was dramatically enhanced by coexpressing a weakly activated allele of Src (E378G) and the two subunits of PI 3-kinase-γ. This activation correlates with new sites of phosphorylation on Btk identified by two-dimensional phosphopeptide mapping. Activation of Btk was dependent on the catalytic activity of all three enzymes and an intact Btk PH domain and Src transphosphorylation site. These combined data define Btk as a downstream target of PI 3-kinase-γ and Src family kinases.

Tomato Phosphate Transporter Genes Are Differentially Regulated in Plant Tissues by Phosphorus1

Phosphorus is a major nutrient acquired by roots via high-affinity inorganic phosphate (Pi) transporters. In this paper, we describe the tissue-specific regulation of tomato (Lycopersicon esculentum L.) Pi-transporter genes by Pi. The encoded peptides of the LePT1 and LePT2 genes belong to a family of 12 membrane-spanning domain proteins and show a high degree of sequence identity to known high-affinity Pi transporters. Both genes are highly expressed in roots, although there is some expression of LePT1 in leaves. Their expression is markedly induced by Pi starvation but not by starvation of nitrogen, potassium, or iron. The transcripts are primarily localized in root epidermis under Pi starvation. Accumulation of LePT1 message was also observed in palisade parenchyma cells of Pi-starved leaves. Our data suggest that the epidermally localized Pi transporters may play a significant role in acquiring the nutrient under natural conditions. Divided root-system studies support the hypothesis that signal(s) for the Pi-starvation response may arise internally because of the changes in cellular concentration of phosphorus.

Cross-talk between the insulin and angiotensin signaling systems.

Angiotensin II (AII), acting via its G-protein linked receptor, is an important regulator of cardiac, vascular, and renal function. Following injection of AII into rats, we find that there is also a rapid tyrosine phosphorylation of the major insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) in the heart. This phenomenon appears to involve JAK2 tyrosine kinase, which associates with the AT1 receptor and IRS-1/IRS-2 after AII stimulation. AII-induced phosphorylation leads to binding of phosphatidylinositol 3-kinase (PI 3-kinase) to IRS-1 and IRS-2; however, in contrast to other ligands, AII injection results in an acute inhibition of both basal and insulin-stimulated PI 3-kinase activity. The latter occurs without any reduction in insulin receptor or IRS phosphorylation or in the interaction of the p85 and p110 subunits of PI 3-kinase with each other or with IRS-1/IRS-2. These effects of AII are inhibited by AT1 receptor antagonists. Thus, there is direct cross-talk between insulin and AII signaling pathways at the level of both tyrosine phosphorylation and PI 3-kinase activation. These interactions may play an important role in the association of insulin resistance, hypertension, and cardiovascular disease.

Avaliação do volume e índices vasculares placentários pela ultrassonografia tridimensional em gestações com restrição grave de crescimento fetal

INTRODUÇÃO: A restrição de crescimento fetal (RCF) representa uma das principais complicações da gravidez e está associada a elevadas taxas de morbimortalidade perinatal. A frequência de desfechos desfavoráveis neonatais está diretamente relacionada à gravidade da RCF, sendo que os casos de pior evolução estão relacionados com peso abaixo do percentil 3. O mecanismo do crescimento fetal não está totalmente esclarecido, mas resulta da interação entre potencial genético de crescimento e fatores placentários, maternos e ambientais. Dentre os fatores etiológicos, o desenvolvimento anormal da placenta e a diminuição da perfusão uteroplacentária são as principais causas de RCF. Este estudo teve por objetivo avaliar volume e índices de vascularização placentários, por meio da ultrassonografia tridimensional (US3D), em gestações com RCF grave, e as correlações dos parâmetros placentários com valores de normalidade e dopplervelocimetria materno-fetal. MÉTODOS: Foram avaliadas 27 gestantes cujos fetos apresentavam peso estimado abaixo do percentil 3 para a idade gestacional. Por meio da US3D, utilizando-se a técnica VOCAL, foram mensurados o volume placentário (VP) e os índices vasculares: índice de vascularização (IV), índice de fluxo (IF) e índice de vascularização e fluxo (IVF). Os dados foram comparados com a curva de normalidade para a idade gestacional e peso fetal descrita por De Paula e cols. (2008, 2009). Desde que os volumes placentários variam durante a gravidez, os valores observados foram comparados com os valores esperados para a idade gestacional e peso fetal. Foram criados os índices volume observado/ esperado para a idade gestacional (Vo/e IG) e volume placentário observado/ esperado para o peso fetal (Vo/e PF). Os parâmetros placentários foram correlacionados com índice de pulsatilidade (IP) médio de (AUt) e IP de artéria umbilical (AU), e avaliados segundo a presença de incisura protodiastólica bilateral em AUt. RESULTADOS: Quando comparadas à curva de normalidade, as placentas de gestação com RCF grave apresentaram VP, IV, IF e IVF significativamente menores (p < 0,0001 para todos os parâmetros). Houve correlação inversa estatisticamente significante da média do PI de AUt com o Vo/e IG (r= -0,461, p= 0,018), IV (r= -0,401, p= 0,042) e IVF (r= -0,421, p= 0,048). No grupo de gestantes que apresentavam incisura protodiastólica bilateral de artérias uterinas, Vo/e IG (p= 0,014), Vo/e PF (p= 0,02) e IV (p= 0,044) foram significativamente mais baixos. Nenhum dos parâmetros placentários apresentou correlação significativa com IP de AU. CONCLUSÕES: Observou-se que o volume e os índices de vascularização placentários apresentam-se diminuídos nos fetos com RCF grave. IP médio de AUT apresenta correlação negativa com Vo/e IG, IV e IVF, e Vo/e IG, Vo/e PF e IV apresentaram-se reduzidos nos casos de incisura bilateral. Não houve correlação significativa dos parâmetros placentários com IP de AU

Reforma del estado como mecanismo de control en democracia delegativa: caso reforma judicial Ecuador 2007-2014

The object of this doctoral thesis is the analysis of the political and administrative purpose that is given to the reform process of a vital sector of State powers within the framework of delegate democracy, such as the administration of Justice. The object is also to analyze if State reform in a diminished or non-liberal surrounding increase or improve conditions of democracy in a given situation, based on the constitutional “what should be”, or if what occurs is a process of “seizure” of the functions of State, which becomes an institutional risk. Finally, we will examine the real and effective existence of a horizontal accountability process through the use of institutional resources, which would evidence the existence of an incomplete model of democracy. This analysis implies the relationship between two institutions within public administration: State Reform, as an act of change in State structure in order to improve qualitatively the outcomes and outputs of public policies, and in sum, to make the system work better. This, as it will be examined later, is the case of Latin America as a response of the State to three processes in crisis: fiscal, as in government intervention or in the form of bureaucratic administration. In that scheme of things, this thesis examines the present state of the art in public administration science of this process to prove that in delegate democracy, this type of instruments disregard the constitutive elements of democracy and serve, especially in critical areas of the administration, allowing for Power to dismiss Law. This research seeks to contribute towards an area seldom analyzed regarding public administration doctrine under the light of the theory of law, which is the connection between previous conditions or principal inputs of an execution process of a democracy and, on the other hand, regarding the effects of introducing a reform within models of a changing democracy and new concepts of the rule of law. While reviewing writings regarding State reform, it is clear that no approximations have been previously made in reference to prior conditions of the political system in order to begin operating a reform which respects fundamental rights as an object of this procedure. Furthermore, no analysis has been found regarding structural change of strategic areas in State services as to the effect caused on democratic exercise and the outcome in an open society...

Padre que amava Moça que amava Carlos que amava Joaquim que amava. Dimensões histórico-críticas do diálogo entre o longa-metragem O padre e a moça (Joaquim Pedro de Andrade, 1965) e o poema \'O padre, a moça\' (Carlos Drummond de Andrade, 1962)

Este trabalho consiste em investigar as relações entre poética e contexto em duas obras: O padre e a moça (longa-metragem ficcional que Joaquim Pedro de Andrade finalizou em 1965), e o poema (de que Joaquim Pedro se apropria) O padre, a moça (publicado por Carlos Drummond de Andrade em Lição de coisas, de 1962). Como se trata de duas obras profundamente dialogais, a investigação sobre o caráter de empenho estético-ideológico orienta-se, evidentemente, pelo cotejo. O contexto dos 1960 (atravessado pelos dilemas da modernização capitalista dependente e periférica) revela-se fundamental para a compreensão de aspectos temático-formais de ambas as obras (uma, anterior ao Golpe de 1964, a outra, imediatamente posterior). A presença do contexto em ambos os textos, entretanto, exige a compreensão sobre as mediações propriamente artísticas. Para tanto, a pesquisa procura orientar-se pelo método de redução estrutural (desenvolvido por Antônio Candido); nem por isso, abre mão de refletir sobre seus pressupostos teórico-metodológicos (tomados à análise estética, mas também às reflexões sociológicas, historiográficas e filosóficas).

Nessy 7.0: entorno de inyección de fallos para Artix-7

El hardware reconfigurable es una tecnología emergente en aplicaciones espaciales.Debido a las características de este hardware, pues su configuración lógica queda almacenada en memoria RAM estática, es susceptible de diversos errores que pueden ocurrir con mayor frecuencia cuando es expuesta a entornos de mayor radiación, como en misiones de exploración espacial. Entre estos se encuentran los llamados SEU o Single Event Upset, y suelen ser generados por partículas cósmicas, pues pueden tener la capacidad de descargar un transistor y de este modo alterar un valor lógico en memoria, y por tanto la configuración lógica del circuito. Por ello que surge la necesidad de desarrollar técnicas que permitan estudiar las vulnerabilidades de diversos circuitos, de forma económica y rápida, además de técnicas de protección de los mismos. En este proyecto nos centraremos en desarrollar una herramienta con este propósito, Nessy 7.0. La plataforma nos permitirá emular, detectar y analizar posibles errores causados por la radiación en los sistemas digitales. Para ello utilizaremos como dispositivo controlador, una Raspberry Pi 3, que contendrá la herramienta principal, y controlará y se comunicará con la FPGA que implementará el diseño a testear, en este caso una placa Nexys 4 DDR con una FPGA Artix-7. Finalmente evaluaremos un par de circuitos con la plataforma.

Cuidador familiar - Um parceiro na prevenção das úlceras por pressão

Relatório de Estágio apresentado para a obtenção do grau de Mestre na área de Enfermagem de Saúde Familiar

The farmers' movement, 1620-1920 /

Includes index.

Letters from an American farmer /

Mode of access: Internet.

Child workers in America /

Mode of access: Internet.

Agricultural credit,

Bibliography: p. [ix]-xiv.

The National debt in war and transition.

Mode of access: Internet.

Rural health and medical care,

Bibliographical footnotes.