Cost-effectiveness Study of Antidiabetic Drugs in Type 2 Diabetes Mellitus Patients From Mumbai, India

Diabetes is fast gaining the status of a potential epidemic in India, with >62 million individuals currently diagnosed with the disease.1 India currently faces an uncertain future in relation to the potential burden that diabetes may impose on the country. An estimated US$ 2.2 billion would be needed to sufficiently treat all cases of type 2 diabetes mellitus (T2DM) in India.2 Many interventions can reduce the burden of this disease. However, health care resources are limited; thus, interventions for diabetes treatment should be prioritized.

Giving the benefit of the doubt: the role of vulnerability in the perception of Dark Triad behaviours.

The 'Dark Triad' of socially aversive personality traits (Machiavellianism, Narcissism, and Psychopathy) is typically associated with grandiosity, callousness, and exploitation. Despite this, people with such traits can be very successful in life, especially in the occupational context. This study investigated the characteristics of individuals who enable and abet people high on Dark Triad traits (e.g. through tolerating unpleasant behaviours, not challenging unethical conduct, etc.). High Dark Triad individuals may be able to identify individuals who are susceptible to social manipulation and who are therefore less likely to challenge their behaviours. This study used a 20-item Vulnerability Scale to capture the characteristics of individuals who fall victim to people high on the Dark Triad traits. Cronbach's alpha for the Vulnerability Scale was .80. Pearson's correlation between total vulnerability scores and each of the Big Five personality traits revealed that predictors of vulnerability to social manipulation include low extraversion, low conscientiousness, high neuroticism, and high agreeableness. The vignette method was used to elicit perceptions of Dark Triad behaviours from those who are found to demonstrate signs of social vulnerability. Differences in response styles on Likert-type statements and open-ended questions were found between the high and low vulnerability groups.

Cryptosporidiosis in farm livestock

Although diarrhoea caused by Cryptosporidium is prevalent in livestock species throughout the world relatively little is known about the species and subtypes of Cryptosporidium found in cattle on Scottish farms. In particular, little is known about the shedding profiles (age when calves become infected and duration of shedding) of the different species found in cattle and how calves become infected. There are several theories about how neonatal calves first become infected with the parasite but the role which adult cattle play in the transmission of the parasite has not been fully addressed. It was previously thought that adult cattle did not become infected with the same species of Cryptosporidium which causes disease in the young calves. Some studies have shown that this may not be true and with the advance of new techniques to discriminate species this is an area which should be revisited. In addition, it is known that it is possible for humans to become infected with Cryptosporidium and show clinical disease early in life and then again later in adulthood. In livestock however, diarrhoea caused by the parasite is generally only seen in neonatal livestock while older animals tend to be asymptomatic. It is not known if this resistance to clinical disease at an older age is due to changes in the host with an increase in age or if prior infection “immunises” the animal and provides protection against re-infection. It is also not known if infection with one isolate of C. parvum will provide protection against infection with another or if the protection formed is species/isolate specific. The main aims of this thesis were to: determine the species and subtypes of Cryptosporidium found in calves on a study farm over a one year period from birth; assess the role which adult cattle play in the transmission of the parasite to newborn calves; develop new typing tools to enable the rapid and easy differentiation of Cryptosporidium species found in cattle and to examine the host-pathogen interactions in animals given serial experimental challenges with distinct Cryptosporidium parvum isolates to determine if the resistance seen in older animals on farms is due to an increase in age or as a result of prior infection. iii A variety of different approaches were taken to achieve these aims. Longitudinal experiments carried out on a study farm revealed that in calves <9 weeks of age the most common species of Cryptosporidium is C. parvum and that all calves in the group became infected with Cryptosporidium within the first two weeks of life. Sample collection from the same animals later in life (at 6 months of age) showed that contrary to most previous studies the most common species detected at in this age group was also C. parvum although, interestingly, the subtype which the calves were shedding was not the same subtype that they were shedding previously. The longitudinal study which investigated the role of adult cattle in the transmission of Cryptosporidium also yielded some interesting results. It was found that most of the adult cattle on this farm were shedding Cryptosporidium albeit intermittently. Speciation of the positive samples revealed that, on this farm, the most predominant species of Cryptosporidium in adult cattle was also C. parvum. This is very unusual as most previous studies have not found this level of infection in older cattle and C. parvum is not usually found in this age group. A number of different subtypes were found in adult cattle and some animals shed more than one subtype over the course of the study. This contradicts prior findings which demonstrated that only one subtype is found on a single farm. The experimental infection trial involving infection of young (<1 week old) and older (6 week old) lambs with distinct C. parvum isolates demonstrated that an increase in age at primary infection reduces the effect of clinical disease. Animals which were infected at <1 week of age were re-challenged at 6 weeks of age with either a homologous or heterologous infection. Results revealed that previous exposure does not protect against re-infection with the same or a different isolate of C. parvum. This study also demonstrated that an increase in infective dose leads to a shorter pre-patent period and that there are variations in the clinical manifestations of different isolates of the same Cryptosporidium species.

Serviços dos ecossistemas prestados pelos estuários : especiação e capacidade de retenção do fósforo

O fator nutricional presente nos sapais não é só importante para os organismos que nele habitam como também apresenta uma importância ecológica a uma maior escala. Exemplifica-se este fato com a capacidade de retenção do Fósforo (P) por parte das plantas podendo estas competir como produto químicos para sua imobilização através da incorporação da sua fração biodisponível para cumprimento dos mecanismos básicos de sobrevivência. O rizosedimento dessas plantas é uma importante fonte de nutrientes necessários para garantia básica da perpetuação de todos os serviços (regulação, provisão, cultural) gerados pelo ambiente. A perda de áreas de sapal foi o motivo principal para a elaboração desta tese visto a preocupação em relação aos impactes que a perda de serviços associados à área de estudo escolhida, o sistema lagunar da Ria de Aveiro, poderá vir sofrer caso aconteçam alterações hídricas (naturais ou antrópicas) mais acentuadas no futuro. Essa tese assume como compromisso chamar a atenção para essa questão como também investigar os mecanismos do ciclo do P este importante nutriente considerado essencial para a manutenção da vida em nosso planeta. Para este estudo foram escolhidas 3 espécies de plantas halófitas representantes do sapal amostral, são elas: Bolbochenous maritimus, Spartina maritima e de Juncus maritimus. As questões levantadas buscam compreender o papel do P nas transformações que ocorrem no rizosedimento das halófitas em 3 diferentes contextos: (i) quando comparados os valores da biomassa de P associado às halófitas estudadas (estudo realizado nos sapais povoados por Spartina maritima e Juncus maritimus) em toda extensão da Ria de Aveiro (ii) quando da disponibilidade de P perante a presença de poluentes inorgânicos no Largo do Laranjo, que corresponde a uma zona historicamente contaminada por metais (estudo realizado no rizosedimento das espécies Bolbochenous maritimus e Juncus maritimus) e (iii) quanto à intrusão superficial da água salgada da laguna (estudo focado na avaliação da perda do P próximo às raízes das halófitas que habitam a zona externa do dique do Baixo Vouga Lagunar (BVL) que corresponde à zona de confluência do Rio Vouga com a Ria de Aveiro). Por meio da análise do rizosedimento e da biomassa das diferentes halófitas predominantes do sapal foi possível verificar que, em relação à carga nutritiva fosfática, de Norte (Canal de São Jacinto/Ovar) a Sul (Canal de Mira) da Ria de Aveiro, a cota do sapal é mais importante do que a natureza espacial do sistema. Esta informação é primordial para a assertividade de futuras medidas de criação e reabilitação das áreas de sapal na Ria de Aveiro. Os estudos realizados nas áreas impactadas (Largo do Laranjo e BVL) incidiram na análise do perfil vertical rizosedimentar das halófitas pertencentes ao sapal médio-alto. Estes estudos revelaram que o rizosedimento dessas halófitas possui características peculiares que definem a dinâmica do ciclo do P de forma bastante característica. O rizosedimento das halófitas presentes no Largo do Laranjo apresentaram teores biodisponíveis de P equivalentes àqueles presentes no rizosedimento de área mais afastada da fonte pontual de contaminação para as mesmas espécies. Numa visão otimista, os resultados revelam que ambos sapais, Largo de Laranjo e Cais do Bico, apresentam condições equiparável para perpetuação dos serviços por eles gerados, que nesse caso se tornam ainda mais valiosos devido a garantia da fitoestabilização dos contaminantes (prevenção da entrada de contaminantes na coluna d’água e na cadeia alimentar). No Baixo Vouga Lagunar a análise espacial do sapal na zona exterior ao dique revelou a perda da diversidade das espécies bem como o aumento da área de vasa e consequentemente a perda dos teores de P associados ao rizosedimento das halófitas mais expostas aos efeitos da compressão costeira intensificados pelas ações naturais e antrópicas a que a Ria está sujeita. Em geral, a degradação dessa área de sapal devido aos fenômenos de assoreamento ou de erosão não pode ser separada dos processos sedimentares na área envolvente, principalmente no caso da Ria de Aveiro que tem sofrido constantes mudanças para atender às necessidades das atividades humanas. Essa tendência provavelmente não mudará no futuro próximo. Consequentemente, a evolução da laguna será principalmente dependente do resultado direto das ações humanas que deverão sempre encontrar formas de compensar os danos causados no âmbito de intervenções de reabilitação do sistema hídrico. A recriação de áreas de sapal pode ter lugar como medida mitigadora no âmbito de intervenções de reabilitação de áreas degradadas e ainda poderá servir como forma de captura de P para programas de utilização de fertilizantes naturais (componente desejável para a agricultura moderna o que é particularmente importante para as regiões altamente dependentes do mercado de importação). Deste modo, recomenda-se que a recuperação das áreas de sapal seja enquadrada no âmbito de intervenções mais amplas de valorização dos sistemas estuarinos e lagunares.

Reconciling History and International Law: Territorial and Maritime Claims in the South China Sea and East China Sea

High-ranking Chinese military officials are often quoted in international media as stating that China cannot afford to lose even an inch of Chinese territory, as this territory has been passed down from Chinese ancestors. Such statements are not new in Chinese politics, but recently this narrative has made an important transition. While previously limited to disputes over land borders, such rhetoric is now routinely applied to disputes involving islands and maritime borders. China is increasingly oriented toward its maritime borders and seems unwilling to compromise on delimitation disputes, a transition mirrored by many states across the globe. In a similar vein, scholarship has found that territorial disputes are particularly intractable and volatile when compared with other types of disputes, and a large body of research has grappled with producing systematic knowledge of territorial conflict. Yet in this wide body of literature, an important question has remained largely unanswered - how do states determine which geographical areas will be included in their territorial and maritime claims? In other words, if nations are willing to fight and die for an inch of national territory, how do governments draw the boundaries of the nation? This dissertation uses in-depth case studies of some of the most prominent territorial and maritime disputes in East Asia to argue that domestic political processes play a dominant and previously under-explored role in both shaping claims and determining the nature of territorial and maritime disputes. China and Taiwan are particularly well suited for this type of investigation, as they are separate claimants in multiple disputes, yet they both draw upon the same historical record when establishing and justifying their claims. Leveraging fieldwork in Taiwan, China, and the US, this dissertation includes in-depth case studies of China’s and Taiwan’s respective claims in both the South China Sea and East China Sea disputes. Evidence from this dissertation indicates that officials in both China and Taiwan have struggled with how to reconcile history and international law when establishing their claims, and that this struggle has introduced ambiguity into China's and Taiwan's claims. Amid this process, domestic political dynamics have played a dominant role in shaping the options available and the potential for claims to change in the future. In Taiwan’s democratic system, where national identity is highly contested through party politics, opinions vary along a broad spectrum as to the proper borders of the nation, and there is considerable evidence that Taiwan’s claims may change in the near future. In contrast, within China’s single-party authoritarian political system, where nationalism is source of regime legitimacy, views on the proper interpretation of China’s boundaries do vary, but along a much more narrow range. In the dissertation’s final chapter, additional cases, such as South Korea’s position on Dokdo and Indonesia’s approach to the defense of Natuna are used as points of comparison to further clarify theoretical findings.

Large Morgagni Hernia in an Adult Patient

A 70-year-old woman presented to the emergency department with symptoms of a lower respiratory infection. A chest x-ray showed enlargement of the mediastinal space. The patient was admitted with a respiratory tract infection and started on antibiotic treatment. A computed tomography (CT) scan of the thorax revealed a large diaphragmatic hernia with stomach, large intestine and caudal pancreas lodged in the thoracic cavity. After the antibiotic treatment, the patient became asymptomatic and surgery repair was declined. Morgagni hernia is an uncommon type of congenital diaphragmatic hernia, which may be asymptomatic until late in life or may be present acutely with life threatening conditions.

Dream characteristics in a Brazilian sample: an online survey focusing on lucid dreaming

During sleep, humans experience the offline images and sensations that we call dreams, which are typically emotional and lacking in rational judgment of their bizarreness. However, during lucid dreaming (LD), subjects know that they are dreaming, and may control oneiric content. Dreaming and LD features have been studied in North Americans, Europeans and Asians, but not among Brazilians, the largest population in Latin America. Here we investigated dreams and LD characteristics in a Brazilian sample (n=3,427; median age=25 years) through an online survey. The subjects reported recalling dreams at least once a week (76%), and that dreams typically depicted actions (93%), known people (92%), sounds/voices (78%), and colored images (76%). The oneiric content was associated with plans for the upcoming days (37%), memories of the previous day (13%), or unrelated to the dreamer (30%). Nightmares usually depicted anxiety/fear (65%), being stalked (48%), or other unpleasant sensations(47%). These data corroborate Freudian notion of day residue in dreams, and suggest that dreams and nightmares are simulations of life situations that are related to our psychobiological integrity. Regarding LD, we observed that 77% of the subjects experienced LD at least once in life (44% up to 10 episodes ever), and for 48% LD subjectively lasted less than 1 min. LD frequency correlated weakly with dream recall frequency (r =0.20,p< 0.01), and LD control was rare (29%). LD occurrence was facilitated when subjects did not need to wake up early (38%), a situation that increases rapid eye movement sleep (REMS) duration, or when subjects were under stress (30%), which increases REMS transitions into waking. These results indicate that LD is relatively ubiquitous but rare, unstable, difficult to control, and facilitated by increases in REMS duration and transitions to wake state. Together with LD incidence in USA, Europe and Asia, our data from Latin America strengthen the notion that LD is a general phenomenon of the human species.

A review of weed management in wheat using crop competition

Wheat occupies a principal place in the diet of humans globally, contributing more to our daily calorie and protein intake than any other crop. For this reason, preventing weed induced yield losses in wheat has high significance for world food sustainability. Herbicides and tillage play an important role in weed control, but their use has often unacceptable consequences for humans and the wider environment. Additionally, the range of herbicides effective on key weeds is dwindling due to the evolution of herbicide resistance. Elevating crop competitiveness against weeds, through a combination of wheat breeding and innovative planting design (planting density, row spacing and orientation), has strong potential to reduce weed-induced yield losses in wheat. The last decade of research has provided a solid foundation for the breeding of weed suppressive wheat cultivars, and continued research in this area should be a focus for the future. In the interim, there is cause for optimism that weeds can be effectively suppressed using existing wheat varieties, through careful cultivar selection and choice of planting design. Further research is required to define the nature of relationships between cultivar traits and competitive planting strategies, across diverse weed flora in multiple countries, sites and seasons. Investment in such innovation promises to produce benefits, not only in terms of sustained wheat yields, but also in terms of human and ecosystem health, through ameliorating chemical and sediment contamination, soil degradation, and CO2 pollution.

Learning Sustainability with EPS@ISEP – Development of a Water Disinfection System

Proceedings of the 8th International Symposium on Project Approaches in Engineering Education (PAEE), Guimarães, 2016

Development of dendritic cells in the intestine

The intestinal tract is exposed to a large variety of antigens such as food proteins, commensal bacteria and pathogens and contains one of the largest arms of the immune system. The intestinal immune system has to discriminate between harmless and harmful antigens, inducing tolerance to harmless antigens and active immunity towards pathogens and other harmful materials. Dendritic cells (DC) in the mucosal lamina propria (LP) are central to this process, as they sample bacteria from the local environment and constitutively migrate to the draining mesenteric lymph nodes (MLN), where they present antigen to naïve T cells in order to direct an appropriate immune response. Despite their crucial role, understanding the function and phenotype of LP DC has been hampered by the fact that they share phenotypic markers with macrophages (mφ), which are the dominant population of mononuclear phagocyte (MP) in the LP. Recent work in our own and other laboratories has established gating strategies and phenotyping panels that allow precise discrimination between intestinal DC and mφ using the mφ specific markers CD64 and F4/80. In this way four bona fide DC subsets with distinct functions have been identified in adult LP based on their expression of CD11b and CD103 and a major aim of my project was to understand how these subsets might develop in the neonatal intestine. At the beginning of my PhD, the laboratory had used these new methods to show that signal regulatory protein α (SIRPα), an inhibitory receptor expressed by myeloid cells, was expressed by mφ and most DC in the intestine, except for those expressing CD103 alone. In addition, mice carrying a non-signalling mutation in SIRPα (SIRPα mt) had a selective reduction in CD103+CD11b+ DC, a subset which is unique to the intestinal LP. This was the basis for the initial experiments of my project, described in Chapter 3, where I investigated if the phenotype in SIRPα mt mice was intrinsic to haematopoietic cells or not. To explore this, I generated bone marrow (BM) chimeric mice by reconstituting irradiated WT mice with SIRPα mt BM, or SIRPα mt animals with WT BM. These experiments suggested that the defect in CD103+CD11b+ DC was not replicated in DC derived from BM of SIRPα origin. However as this seemed inconsistent with other data, I considered the possibility that 18 the phenotype may have been lost with age, as the BM chimeric mice were considerably older than those used in the original studies of SIRPα function. However a comparison of DC subsets in the intestine of WT and SIRPα mt mice as they aged provided no conclusive evidence to support this idea. As these experiments did show age-dependent effects on DC subsets, in Chapter 4, I went on to investigate how the DC populations appeared in the intestine and other tissues in the neonatal period. These experiments showed there were few CD103+CD11b+ DC present in the LP and migratory DC compartment of the MLN in the neonate and that as this population gradually increased in proportion with age, there was a reciprocal decrease in the relative proportion of CD103-CD11b+ DC. Interestingly, most of the changes in DC numbers in the intestine were found during the second or third week of life when the weaning process began. To validate my findings that there were few CD103+CD11b+ DC in the neonate and that this was not merely an absence of CD103 upregulation, I examined the expression of CD101 and Trem-1, markers that other work in the laboratory had suggested were specific to the CD103+CD11b+ DC lineage. My work showed that CD101 and Trem-1 were co- expressed by most CD103+CD11b+ DC in small intestine (SI) LP, as well as a small subset of CD103-CD11b+ DC in this tissue. Interestingly, Trem-1 was highly specific to the SI LP and migratory DC in the MLN, but absent from the colon and other tissues. CD101 expression was also only found on CD11b+ DC, but showed a less restricted pattern of distribution, being found in several tissues as well as the SI LP. The relative timing of their development suggested there might be a relationship between CD103+CD11b+ and CD103-CD11b+ DC and this was supported by microarray analysis. I hypothesised that the CD103-CD11b+ DC that co-expressed CD101 and Trem-1 may be the cells that developed into CD103+CD11b+ DC. To investigate this I analysed how CD101 and Trem-1 expression changed with age amongst the DC subsets in SI LP, colonic LP (CLP) and MLN. The proportion of CD101+Trem-1+ cells increased amongst CD103+CD11b+ DC in the SI LP and MLN with age, while amongst CD103+CD11b+ DC in the CLP this decreased. This was not the same in CD103-CD11b+ DC, where CD101 and Trem-1 expression was more varied with age in all tissues. CD101 and Trem-1 were not expressed to any great extent on CD103+CD11b- or CD103-CD11b- DC. The phenotypic development of the 19 intestinal DC subsets was paralleled by the gradual upregulation of CD103 expression, while the production of retinoic acid (RA), as assessed by the AldefluorTM assay, was low early in life and did not attain adult levels until after weaning. Thus DC in the neonatal intestine take some time to acquire the adult pattern of phenotypic subsets and are functionally immature compared with their adult counterparts. In Chapter 5, I used CD101 and Trem-1 to explore the ontogeny of intestinal DC subsets in CCR2-/- and SIRPα mt mice, both of which have selective defects in one particular group of DC. The selective defect seen amongst CD103+CD11b+ DC in adult SIRPα mt mice was more profound in mice at D7 and D14 of age, indicating that it may be intrinsic to this population and not highly dependent on environmental factors that change after birth. The expression of CD101 and Trem-1 by both CD103+CD11b+ and CD103-CD11b+ DC was reduced in SIRPα mt mice, again indicating that this entire lineage was affected by the lack of SIRPα signalling. However there was also a generalised defect in the numbers of all DC subsets in many tissues from early in life, suggesting there was compromised development, recruitment or survival of DC in the absence of SIRPα signalling. In contrast to the findings in SIRPα mt mice, more CD103+CD11b+ DC co-expressed CD101 and Trem-1 in CCR2-/- mice, while there were no differences in the expression of these molecules amongst CD103-CD11b+ DC. This may suggest that CCR2+ CD103-CD11b+ DC are not the cells that express CD101 and Trem-1 that are predicted to be the direct precursors of CD103+CD11b+ DC. I also examined the expression of DC growth factor receptors on DC subsets from mice of different ages, but no clear age or subset- related patterns of the expression of mRNA for Csf2ra, Irf4, Tgfbr1 and Rara could be observed. Next, I investigated whether Trem-1 played any role in DC development. Preliminary experiments in Trem-1-/- mice show no differences between any of the DC subsets, nor were there any selective effects on individual subsets when DC development from Trem-1-/- KO and WT BM was compared in competitive chimeras. However these experiments were difficult to interpret due to viability problems and because I found an unexpected defect in the ability of Trem-1-/- BM to generate all DC, irrespective of whether they expressed Trem-1 or not. 20 The final experiments I carried out were to examine the role of the microbiota in driving the differentiation of intestinal DC subsets, based on the hypothesis that this could be one of the environmental factors that might influence events in the developing intestine. To this end I performed experiments in both antibiotic treated and germ free adult mice, both of which showed no significant phenotypic differences amongst any of the DC subsets. However the study of germ free mice was compromised by recent contamination of the colony and may not be the conclusive answer. Together the data in this thesis have shown that the population of CD103+CD11b+ DC, which is unique to the intestine, is not present at birth. These cells gradually increase in frequency over time and as this occurs there is a reciprocal decrease in the frequency of CD103-CD11b+ DC. Along with other results, this leads to the idea that there may be a linear developmental pathway from CD103-CD11b+ DC to CD103+CD11b+ DC that is driven by non-microbial factors that are located preferentially in the small intestine. My project indicates that markers such as CD101 and Trem-1 may assist the dissection of this process and highlights the importance of the neonatal period for these events.

Las relaciones de convivencia de los niños, niñas y adolescentes sordos o hipoacústicos: estudio cualitativo exploratorio

Estudio cualitativo exploratorio con enfoque fenomenológico que estudió en 10 Niños, Niñas y Adolescentes Sordos / HipoAcústicos (NNA-S/HA) las relaciones de convivencia con la familia, los profesionales de salud, los maestros, los amigos, la comunidad sorda; las cualidades de resiliencia de los NNA-S/HA encontró que las madres aunque tienen altos niveles de estrés son las que afrontan las dificultades y apoyan la intervención, los NNA-S/HA se refugian en sus madres; y los padres se retraen en sus sentimientos y evaden los problemas, y por eso abandonan el hogar al enterarse de que su hijo es sordo. Los profesionales carecen de estrategias para la atención y la comunicación, son distantes del NNA-S/HA, las familias relatan mala calidad en los servicios de salud. Los maestros y los amigos de los NNA-S/HA que van escuelas regulares les excluyen causando convivencias desagradables para los NNA-S/HA. Aquellos que se encuentran en la escuela para sordos se sienten más adaptados, con mejor autoestima y son más resiliente. La mitad de los NNA-S/HA usan dispositivos auditivos pero todos usan o lengua de señas formal o señas familiares para comunicarse con sus amigos y familias. Los NNA-S/HA que usan los dispositivos auditivos no tienen contacto con la comunidad sorda de su región no así los otros que no lo usan y cuya lengua principal es la de señas. Los NNA-S/HA desarrollan como todos los demás sueños, proyectos de vida y luchan por conseguirlo. El estudio permite plantear hipótesis para futuras investigaciones en torno a las estrategias de afrontamiento de las familias, la resiliencia de los NNA-S/HA y la asociación con las relaciones de convivencia.

Habitat selection and phenotypic diversity in the anchovy of the Bay of Biscay

Diversity among individuals in a population is an important feature linking vital rates with behaviour and spatial occupation. We measured the growth increments in the otolith of individual fishes collected on the annual fisheries survey PELGAS from 2001 to 2015. Individuals who grew larger at juvenile stage occupied later in life more off-shore habitats. Further, we analysed the allozymes of 13 different loci from 2001 to 2006. Alleles of the enzyme IDH showed different frequencies in inshore and offshore habitats. The population spatially segregates along a coast to off-shore gradient with individuals showing different early growth and allele frequencies. Results show how individuals in a population segregate spatially in different habitats in relation with phenotypic diversity. This implies modelling the population with individual-based and physiological approaches to fully grasp its dynamics. It also implies developing management strategies to conserve infra-population diversity as a means to garantee the occupation of the full range of habitats.

Benefícios afetivossociais da prática da dança para estudantes dos núcleos de arte da Prefeitura do Rio de Janeiro

O propósito desta pesquisa foi investigar o papel atribuído à Dança, no âmbito da dimensão afetivossocial compreendendo como se reflete na vida (pessoal e social) dos jovens estudantes dos oito Centros de Pesquisa e Formação em Ensino Escolar de Arte e Esporte – Núcleo de Arte da Prefeitura do Rio de Janeiro – distribuídos em distintas regiões do município do Rio de Janeiro. A base teórica do estudo foi fundamentada pela dimensão afetivossocial em autores de referência da área (Bertine, 2014; Damásio, 2012; 2013; Godoy, 2013; Leme, 2013; Macara 2010a, 2010b; Marques, 2010; 2014; Matos & Tomé, 2012; Monteiro, 2012; Shapiro, 2008; Stinson, 2014; Strongman, 2002; Sawaia, 2014; Varregoso et al., 2014). Com este desígnio, o trajeto metodológico percorrido para construção da tese decorreu em duas fases. A primeira de natureza exploratória, marcada por dois Estudos Preliminares. A segunda de natureza pluri-metodológicos: Pesquisa de Método Misto, com a combinação entre a abordagem quantitativa e qualitativa, marcada por um estudo de campo. Participaram do estudo quantitativo 378 praticantes de Dança de 12 a 18 anos de idade e do estudo qualitativo 52 integrantes do espaço (diretores, professores, coordenador e praticantes e ex-praticantes). O método de análise adotado foi estatístico descritivo e correlação de Pearson pelo SPSS22 e, análise de conteúdo. Todos os dados analisados foram integrados nas duas dimensões do estudo, Dimensão Representação Afetivossocial e Dimensão Transformação Pessoal e Social. Como resultado, verificamos que os jovens sentem-se motivados e incluídos pelo trabalho realizado nas oficinas de Dança nos núcleos, percebem que a Dança é fonte de empoderamento da dimensão afetivossocial pelo despertar da motivação, do bem-estar e da autorealização. No campo afetivo, descrevem o desenvolvimento das competências emocionais pelas sensações, emoções e sentimentos gerados no corpo e nas experiências relacionais na Dança, despertando o conactus (Damásio, 2012; Leme, 2013) e a potência de ação (Sawaia, 2014), capazes de transformar estados emocionais, situações e coisas em benefício próprio. O desenvolvimento das competências sociais transcorreu pela mudança comportamental em casa, pela tríade interação-participação-transformação social no núcleo, família, escola e comunidade despertando sentimentos na construção da dimensão afetivossocial e promovendo liberdade de ser e estar no mundo. Com o desenvolvimento destas competências, estes jovens percebem-se incluídos na sociedade despertando para muitos o desejo de prosseguimento na carreira (Amadora ou Profissional).

Modelação de taxas de resgate em seguros de vida

Mestrado em Ciências Actuariais

Violação e rutura do contrato psicológico: efeitos no engagement pela vida, na paixão pelo trabalho e nos sonhos dos profissionais de uma unidade de saúde

Dissertação de Mestrado, Gestão de Recursos Humanos, Escola Superior de Gestão, Hotelaria e Turismo, Faculdade de Ciências Humanas e Sociais, Universidade do Algarve, 2015