782 resultados para Engel, Antke


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"Bibliographisches Verzeichnis": p.[101]-120.

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Top Row: st. mngr. Dale Sawyer, Jeff Engel, Len Cercone, Ray Locke, Steve Williams, Ergas Leps, Larry Beamer, asst. coach J. Elmer Swanson.

3rd Row: Quinton Sterling, James Wyman, Jim Montour

Second Row: John Gregg, L. Bryan Gibson, Dave Martin, Terry Trevarthen, Richard Cephas, Walter Schafer, Marshall Dickerson, Frank Geist, Don Chalfant.

Front Row: Jack Steffes, Fred Montour, Tom Robinson, Coach Don Canham, captain Earl Deardorff, Dick Schwartz, Ron Trowbridge.

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Top Row: Douglas Niles, Frederick Langille, Wallace Herrala, Charles Peltz, Jeff Engel.

3rd Row: asst. coach Elmer Swanson, Richard Thelwell, Carter Reese, Jerry Gerich, Stephen Overton, Charles Aquino, James Montour.

2nd Row: Rodney Denhart, William Hornbeck, Bennie McRae, John Gregg, Raymond Locke, Frank Geist, L. Bryan Gibson, Donald Chalfant.

Front now Lester Bird, Marshall Dickerson, Richard Cephas, Ergas Leps, Coach Don Canham, David Martin, James Wyman, Walter Schafer.

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Errata tipped in following p. viii.

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Thesis (doctoral)--Universitat Jena.

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Thesis (doctoral)--Universität Bern, 1904.

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Mode of access: Internet.

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Thesis (doctoral)--Friedrich-Alexanders-Universitat Erlangen.

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Thesis (doctoral)--Universitat Marburg.

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Mode of access: Internet.

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Mode of access: Internet.

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Mode of access: Internet.

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Pseudomonas aeruginosa is an important pathogen in immunocompromised patients and secretes a diverse set of virulence factors that aid colonization and influence host cell defenses. An important early step in the establishment of infection is the production of type III-secreted effectors translocated into host cells by the bacteria. We used cDNA microarrays to compare the transcriptomic response of lung epithelial cells to P. aeruginosa mutants defective in type IV pili, the type III secretion apparatus, or in the production of specific type III-secreted effectors. Of the 18,000 cDNA clones analyzed, 55 were induced or repressed after 4 It of infection and could be classified into four different expression patterns. These include (i) host genes that are induced or repressed in a type III secretion-independent manner (32 clones), (ii) host genes induced specifically by ExoU (20 clones), and (iii) host genes induced in an ExoU-independent but type III secretion dependent manner (3 clones). In particular, ExoU was essential for the expression of immediate-early response genes, including the transcription factor c-Fos. ExoU-dependent gene expression was mediated in part by early and transient activation of the AN transcription factor complex. In conclusion, the present study provides a detailed insight into the response of epithelial cells to infection and indicates the significant role played by the type III virulence mechanism in the initial host response.