Bubble growth by injection of gas into viscous liquids in cylindrical and conical tubes.

The laminar low Mach number flow of a gas in a tube is analyzed for very small and very large values of the inlet-to-wall temperature ratio. When this ratio tends to zero, pressure forces confine the cold gas to a thin core around the axis of the tube. This core is neatly bounded by an ablation front that consumes it at a finite distance from the tube inlet. When the temperature ratio tends to infinity, the temperature of the gas increases smoothly from the wall to the axis of the tube and the shear stress and heat flux are positive at the wall despite the fact that the viscosity and thermal conductivity of the gas scaled with their inlet values tend to zero at the wall.

Identification of a biomarker panel for colorectal cancer diagnosis

Background Malignancies arising in the large bowel cause the second largest number of deaths from cancer in the Western World. Despite progresses made during the last decades, colorectal cancer remains one of the most frequent and deadly neoplasias in the western countries. Methods A genomic study of human colorectal cancer has been carried out on a total of 31 tumoral samples, corresponding to different stages of the disease, and 33 non-tumoral samples. The study was carried out by hybridisation of the tumour samples against a reference pool of non-tumoral samples using Agilent Human 1A 60-mer oligo microarrays. The results obtained were validated by qRT-PCR. In the subsequent bioinformatics analysis, gene networks by means of Bayesian classifiers, variable selection and bootstrap resampling were built. The consensus among all the induced models produced a hierarchy of dependences and, thus, of variables. Results After an exhaustive process of pre-processing to ensure data quality--lost values imputation, probes quality, data smoothing and intraclass variability filtering--the final dataset comprised a total of 8, 104 probes. Next, a supervised classification approach and data analysis was carried out to obtain the most relevant genes. Two of them are directly involved in cancer progression and in particular in colorectal cancer. Finally, a supervised classifier was induced to classify new unseen samples. Conclusions We have developed a tentative model for the diagnosis of colorectal cancer based on a biomarker panel. Our results indicate that the gene profile described herein can discriminate between non-cancerous and cancerous samples with 94.45% accuracy using different supervised classifiers (AUC values in the range of 0.997 and 0.955)

Relativistic current collection by a cylindrical Langmuir probe

The current I to a cylindrical Langmuir probe with a bias Φp satisfying β≡eΦp/mec2∼O(1) is discussed. The probe is considered at rest in an unmagnetized plasma composed of electrons and ions with temperatureskTe∼kTi≪mec2. For small enough radius, the probe collects the relativistic orbital-motion-limited (OML) current I OML , which is shown to be larger than the non-relativistic result; the OML current is proportional to β1/2 and β3/2 in the limits β≪1 and β≫1, respectively. Unlike the non-relativistic case, the electron density can exceed the unperturbed density value. An asymptotic theory allowed to compute the maximum radius of the probe to collect OML current, the sheath radius for probe radius well below maximum and how the ratio I/I OML drops below unity when the maximum radius is exceeded. A numerical algorithm that solves the Vlasov-Poisson system was implemented and density and potential profiles presented. The results and their implications in a possible mission to Jupiter with electrodynamic bare tethers are discussed density value. An asymptotic theory allowed to compute the maximum radius of the probe to collect OML current, the sheath radius for probe radius well below maximum and how the ratio I/IOML drops below unity when the maximum radius is exceeded. A numerical algorithm that solves the Vlasov-Poisson system was implemented and density and potential profiles presented. The results and their implications in a possible mission to Jupiter with electrodynamic bare tethers are discussed.

Electrooptic characterization of tunable cylindrical liquid crystal lenses

In this work, one-dimensional arrays of cylindrical adaptive liquid crystal lenses were manufactured and characterized; and test devices were filled with nematic liquid crystal. Comb interdigitated electrodes were designed as a mask pattern for the control electrode on the top glass substrates. A radial graded refractive index along each microsized lens was achieved by fabricating a layer of high resistance sheet deposited as a control electrode. These tunable lenses were switched by applying amplitude and frequency optimized waveforms on the control electrode. Phase profiles generated by the radial electric field distribution on each lens were measured by a convectional interferometric technique.

Methods for noise reduction in far-field patterns obtained from cylindrical near-field antenna measurements

Two different methods to reduce the noise power in the far-field pattern of an antenna as measured in cylindrical near-field (CNF) are proposed. Both methods are based on the same principle: the data recorded in the CNF measurement, assumed to be corrupted by white Gaussian and space-stationary noise, are transformed into a new domain where it is possible to filter out a portion of noise. Those filtered data are then used to calculate a far-field pattern with less noise power than that one obtained from the measured data without applying any filtering. Statistical analyses are carried out to deduce the expressions of the signal-to-noise ratio improvement achieved with each method. Although the idea of the two alternatives is the same, there are important differences between them. The first one applies a modal filtering, requires an oversampling and improves the far-field pattern in all directions. The second method employs a spatial filtering on the antenna plane, does not require oversampling and the far-field pattern is only improved in the forward hemisphere. Several examples are presented using both simulated and measured near-field data to verify the effectiveness of the methods.

Identification of a biomarker panel for colorectal cancer diagnosis

Background:Malignancies arising in the large bowel cause the second largest number of deaths from cancer in the Western World. Despite progresses made during the last decades, colorectal cancer remains one of the most frequent and deadly neoplasias in the western countries. Methods: A genomic study of human colorectal cancer has been carried out on a total of 31 tumoral samples, corresponding to different stages of the disease, and 33 non-tumoral samples. The study was carried out by hybridisation of the tumour samples against a reference pool of non-tumoral samples using Agilent Human 1A 60-mer oligo microarrays. The results obtained were validated by qRT-PCR. In the subsequent bioinformatics analysis, gene networks by means of Bayesian classifiers, variable selection and bootstrap resampling were built. The consensus among all the induced models produced a hierarchy of dependences and, thus, of variables. Results: After an exhaustive process of pre-processing to ensure data quality--lost values imputation, probes quality, data smoothing and intraclass variability filtering--the final dataset comprised a total of 8, 104 probes. Next, a supervised classification approach and data analysis was carried out to obtain the most relevant genes. Two of them are directly involved in cancer progression and in particular in colorectal cancer. Finally, a supervised classifier was induced to classify new unseen samples. Conclusions: We have developed a tentative model for the diagnosis of colorectal cancer based on a biomarker panel. Our results indicate that the gene profile described herein can discriminate between non-cancerous and cancerous samples with 94.45% accuracy using different supervised classifiers (AUC values in the range of 0.997 and 0.955).

Interference of parallel cylindrical Langmuir probes

Current to a cylindrical probe of arbitrary cross section is discussed. Previous results for circular cylinders at the high bias and moderate radius R of interest for electrodynamic bare tethers, for which space charge may be ignored over a large neighborhood of the probe, depend in separate ways on both R and perimeter p. These results are extended to a general convex cross section by introducing certain equivalent radius Req. For any concave cross section, results use a proper equivalent perimeter peq , in addition to Req. Finally, for the joint cross section of separate parallel probes, certain effective perimeter peff replaces peq. Rules to determine Req. peq. and peff are used to discuss collection interference among two or more parallel cylinders when brought from far away to contact

Application of postprocessing techniques methods for noise reduction in cylindrical near field antenna measurements

Three different methods to reduce the noise power in the far-field pattern of an antenna when it is measured in a cylindrical near field system are presented and compared. The first one is based on a modal filtering while the other two are based on spatial filtering, either on an antenna plane or either on a cylinder of smaller radius. Simulated and measured results will be presented.

The orbital-motion-limited regime of cylindrical Langmuir probes

An asymptotic analysis of electron collection at high bias Fp serves to determine the domain of validity of the orbital-motion-limited regime of cylindrical Langmuir probes, which is basic for the workings of conductive bare tethers. The radius of a wire collecting OML current in an unmagnetized plasma at rest cannot exceed a value, Rmax , which is found to exhibit a minimum as a function of Fp ; atFp values of interest, Rmax is already increasing and is larger than the electron Debye length lDe . The breakdown of the regime relates to conditions far fromthe probe, at electron energies comparable to the ion thermal energy, kTi ; Rmax is found to increase with Ti . It is also found that ~1! the maximumwidth of a thin tape, if used instead of a wire, is 4Rmax ; ~2! the electron thermal gyroradius must be larger than both R and lDe for magnetic effects to be negligible; and ~3! conditions applying to the tether case are such that trapped-orbit effects are negligible.

Cylindrical Langmuir probes beyond the orbital-motion-limited regime

The current I to a cylindrical probe at rest in an unmagnetized plasma, with probe bias highly positive, is determined. The way I lags behind the orbital-motion-limited OMLcurrent, 1 OML R, as the radius R exceeds the maximum radius for the OML regime to hold, is of interest for space-tether applications. The ratio I/I OML is roughly a decreasing function of R/lD R max /lDe , which is independent of bias, with lDe the electron Debye length and Rmax /l De roughly an increasing function of the temperature ratio, Ti /Te. The dependence of current on ion energy is used to discuss the effect of probe motion through the plasma, a case applying to tethers in low orbit.

Una casa para Einstein: Konrad Wachsmann y la evolucion de un modelo prefabricado desde las casas "Christoph & Unmack A.G." al "General Panel System"

Este artículo estudia la evolución de un modelo de vivienda prefabricada en madera, ejemplificada en la casita de verano que construye Konrad Wachsmann para Albert Einstein en 1929 en Caputh, cerca de Potsdam. El físico deseaba construirse un "lugar de descanso", eligiendo la construcción en madera por su facilidad y rapidez de montaje, adaptabilidad, calidez y para que armonizara mejor con el medio ambiente en el paraje donde se insertaba. Konrad Wachsmann, que trabajaba para la firma de viviendas prefabricadas en madera "Christoph&Unmack A.G." le presentará un modelo prefabricado moderno. Esta tipología, que había evolucionado desde los diseños iniciales "nórdico escandinavos", pasando por el "jugendstil", hasta introducir un nuevo lenguaje de líneas puras, cubierta plana, y grandes ventanales iniciado por Poelzig, será ligeramente modificada por Einstein, que finalmente adjudica el encargo. Ayudado por Einstein a trasladarse a EEUU, Konrad Wachsmann continuará allí la labor de investigación sobre vivienda prefabricada junto con Walter Gropius, que dará como resultado el "General Panel System" y sus conocidas "Packaged Houses". A HOUSE FOR EINSTEIN: KONRAD WACHSMANN AND THE EVOLUTION OF A PREFABRICATED WOODEN HOUSING MODEL FROM " CHRISTOPH & UNMACK A.G." TO "GENERAL PANEL SYSTEM". This article studies the evolution of a prefabricated wooden housing model, exemplified in the summer house built by Konrad Wachsmann for Albert Einstein in 1929, in Caputh, near Potsdam. The Physician wanted to build a "resting house", choosing a wood construction because of its easy and fast assembly, adaptability, warmth and harmony with the environment where it would be inserted. Konrad Wachsmann, who worked for the wooden prefabricated houses firm "Christoph & Unmack AG", proposed Einstein a modern prefabricated wood model. This typology, which had evolved from the initial "Nordic Scandinavian" and "Jugendstil" designs to a new modern language initiated by Poelzig (with clean lines, flat roof, and large windows) will be slightly modified by Einstein, that finally hired the construction of the house. Aided by Einstein to move to USA, Konrad Wachsmann continued there his research work about prefabricated houses with Walter Gropius, giving as a results the "General Panel System" and the popular "Packaged Houses".

Optically Induced Reorientation in Nematic Cylindrical Structures

Cyclindrical structures of nematics give rise to several opto-optical effects related to molecular reorientation. One of these effects is the formation of diffraction ring patterns similar to the ones observed in planar cells, but differing in shape. Another effect has been observed, namely a quasi-chaotic motion of rings with a very large angular spread; this motion can be obtained using a cw laser and high power densities. The phenomenon could be attributed to thermal motion, however, there are some features that cannot be explained by a purely thermal effect, e.g., a wavelength dependence of the threshold and the frequencies of the ring motion.

Analysis of the performance of caissons with a yard and cylindrical geometry as a breakwater. Apollonius caisson

En el presente trabajo se analiza el cajón Apolonio como diseño conceptual para controlar la reflexión en monolitos de gravedad sometidos a esfuerzos dinámicos de oleaje.

Finite elastic deformations of transversely isotropic circular cylindrical tubes

We consider the finite radially symmetric deformation of a circular cylindrical tube of a homogeneous transversely isotropic elastic material subject to axial stretch, radial deformation and torsion, supported by axial load, internal pressure and end moment. Two different directions of transverse isotropy are considered: the radial direction and an arbitrary direction in planes normal locally to the radial direction, the only directions for which the considered deformation is admissible in general. In the absence of body forces, formulas are obtained for the internal pressure, and the resultant axial load and torsional moment on the ends of the tube in respect of a general strain-energy function. For a specific material model of transversely isotropic elasticity, and material and geometrical parameters, numerical results are used to illustrate the dependence of the pressure, (reduced) axial load and moment on the radial stretch and a measure of the torsional deformation for a fixed value of the axial stretch.