Avaliações farmacoeconômicas em vigilância de medicamentos

The study aimed to identify pharmacoeconomic studies in pharmacovigilance and to observe the economic outcomes in post-marketing surveillance. Therefore, a bibliographic survey was performed in databases Lilacs, PubMed/ Bireme. The search strategy was done by using scientific health descriptors [ "adverse drug reaction reporting systems " OR " medication errors " OR "product surveillance, postmarketing" OR " sentinel surveillance" ] AND [ " cost-benefit analysis" OR "cost efficiency analysis " OR " costs and cost analysis " OR " hospital costs " OR " cost-effectiveness " OR " cost-effectiveness evaluation " OR " drug costs " ]. Manuscripts published in the last 10 years were selected. We chose 13 articles, of which 12 corresponded to cost-benefit analysis and only one to cost-effectiveness assessment. In only one study there was no economy, all the other ones generated savings, ranging from 13.7 to 30% in spending valued service. Surveillance actions were: continuing education; active search through tracking devices and / or implementation of round; teamwork and multidisciplinary deployment; computerized security services management, enabling traceability of information and alerts. The results of the proposed actions have led to the prevention of adverse drug reactions, to decline of risks to the patient, to the reduction of inappropriate prescriptions, as well as the length of hospital stay spending valued service. Surveillance actions were: continuing education; active search through tracking devices and / or implementation of round; teamwork and multidisciplinary deployment; computerized security services management, enabling traceability of information and alerts. The results of the proposed actions have led to the prevention of adverse drug reactions, to decline of risks to the patient, to the reduction of inappropriate prescriptions, as well as the length of hospital stay

A importância da atenção farmacêutica após a verificação da qualidade microbiológica de medicamentos contendo paracetamol encontrados em algumas residências de Américo Brasiliense - SP

It is known that a high microbial count can compromise the stability of medicines, thus reducing their therapeutic efficacy. This work tried to demonstrate that the microbial contamination can be directly related to the inadequate handling of the medicines stored in homes, making it possible to draw strategies to reduce the possible risks of medical therapy offering correct information and advising. The objective of this work was to evaluate the quality of the medicines containing paracetamol found in the residences of Américo Brasiliense-SP, using the microbial analysis of non-sterile method described in the Brazilian Pharmacopoeia (1988). The medicine samples (30 samples) were obtained directly from the interviewed local residents, who had received new medicine bottles of the same product. An analysis of viable microorganisms (bacteria and fungus) was carried out to identify pathogens found in the collected samples. Although 90% of the analyzed samples have shown some microbial contamination, the results indicated the absence of pathogenic microorganisms, and the total count of viable microorganisms was below the maximum value for non-sterile (104 UFC/g or mL). It was also verified that the local residents stored the medicines in appropriate places, according to the orientations received when they bought the medicines in pharmacies and drugstores, showing the importance of information for the correct use and conservation of pharmaceuticals.

Acesso, segurança e uso de medicamentos por usuários

The present study aims to identify families who have stock and are making use of medications, as well as assess the conditions of storage, security and use of these drugs. The study was conducted in a city of São Paulo, the interviews were conducted in households enrolled in one of ten units of the Estratégia de Saúde da Família (ESF) that the city provides and the sample was defined by means of stratified random sampling (134households, IC 95%). Data collection was conducted through interviews with a semistructured questionnaire during the first half of 2011. We interviewed 118 (88.0%) households, of which 112 (95.0%) had medications that were stored n insecure or inadequate places in 75.4% of households, non-prescription self-medication was a common practice in 46 (47 4%) households, and lack of identification and security of medications stored was observed in 60 (53.6%) households. Most households had stock of medicines, which were done improperly or unsecure, or have specialties with lack of identification and security, which can lead to poisoning or e ineffective therapy. The Pharmaceutical Assistance under SUS lacks social initiatives, with actions directed for medications users, which can be supplied by the presence of the pharmacist in the ESF, essential for the promotion of racional use of medicines, that, through the Pharmaceutical Care, can identify, correct and prevent possible problems related to drugs.

Construção e calibração de um inclinômetro para uso em tratores agrícolas como instrumento de segurança

The tractors are the main potency source, for the traction of tillage equipments and their use are increasing more and more in Brazilian agriculture. In spite of the great technological progress the increase of the number of agricultural tractors brought positive aspects and some negative, among these last ones it stands out the appearance of a new source of work accidents, which importance is given by the physical damages caused to the operator. Therefore the objective of this work was to project and develop an inclinometer, which indicates the inclination of the land, as safety sensor for agricultural tractors to avoid lateral hollovers, through a resonant sign, for the operator and the machine preservation. The built and evaluated inclinometer showed to be efficient for inclination indication of different areas during field operations with agricultural tractors, small angle oscillation and enough answer time to help operators to take decisions in imminence situation of lateral machine hollovers.

Calibração de um equipamento TDR (Reflectometria por Dominio do Tempo) para a Determinação da Umidade da Madeira de Grevillea robusta (Cunn.)

This study aimed to establish a calibration model of a TDR equipment to determinate thewood moisture of Grevillea robusta (Cunn.). It was selected alleatory, 11 logs of Grevillea robusta (Cunn.), it was dried in a regulate electric greenhouse at 40o C. During the dry process, the moisture was determinate, periodically and systematically by gravimetric and TDR methods. Through the gravimetric method, moisture vary from 125,88% to 6,62% while the TDR method, the variation was from 119,83% to 5,79%. The best model adjusted to the wood moisture in the determination of the function of relative dielectric constant, using this technique, was the exponential 50,20 132,72 140,27 K U e − = − ⋅ , with a R2 = 0,96, with indicator of trust or performance 0,97 they were classified as very good, according to Camargo and Sentelhas (1997). The correlation between the gravimetric method (reference) and TDR, showed to be equivalent for both methodologies. It was concluded that the TDR can be used to the determination of wood moisture of Grevillea robusta (Cunn.), in a precise and fast way, once it was established it calibration.

Bulas e Cartelas de Medicamentos: Possíveis soluções de leiturabilidade através do Design Gráfico

The package inserts for drugs represent the main source of written information provided to patients, but the deficiency in the page layouts of informational texts (readability), the excess of information and use of techno-scientific language hamper the effectiveness of communication between the author (manufacturer) and player (patient) in addition to the physiological conditions of patients are often elderly. This article discusses these issues from theoretical predictions, and proposes solutions to the adequacy of information graphics package inserts of drugs and facilitating the identification of drug cards.

Método para controle da qualidade de medicamentos sólidos por difração de raios X

Pós-graduação em Química - IQ

Seleção de genótipos de soja portadores ou não do gene RR por meio de análise multivariada e desempenho agronômico

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estanho em amostras ambientais por espectrometria de fluorescência atômica (AFS)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Queixas técnicas e eventos adversos a medicamentos notificados em um hospital sentinela do interior de São Paulo, 2009-2010

Objective: to describe technical complaints and adverse drug events reported in a sentinel hospital in São Paulo state in 2009 and 2010. Methods: This is a descriptive study. Information was obtained from the sentinel hospital Risk Management database. Results: we found 199 reports related to drugs: 70.0% were technical complaints, 21.0% ineffective therapy and 9.0% adverse reaction to medication. The pharmacological groups with highest number of reports were: drugs that act on alimentary tract and metabolism (25.1%), the nervous system (25.1%) and anti-infective drugs for systemic use (22.1%). Conclusion: technical complaints and adverse drug events were frequent, despite recognized underreporting. The characterization of these events could inform the adoption of control measures and permanent educational actions in health services in order to prevent their occurrence.

Medicamentos anti-hipertensivos na gestação e puerpério

Pregnancy toxemia is a multisystemic disease, which occurs mainly at the end of pregnancy, characterized by clinical manifestations such as hypertension, edema and proteinuria. It is the most commonly occurred medical complication in pregnancies and the main cause for perinatal and maternal morbimortalities. The purpose of this article is to review the main aspects concerning the use of antihypertensive agents during pregnancy and puerperium. The data has been collected from Pubmed and Bireme, from 2006 to 2010 using the words “anti-hipertensivo e gravidez” and “antihypertensive and pregnancy”. The knowledge regarding hypertension during pregnancy and its therapy is evolving; the search for medication that could protect the mother from acute dangers and to ensure a healthy newborn must be the focus. Evidence is still lacking regarding the best therapy, beginning period, duration and results. In spite of the pharmacological advances, there are still no drugs completely exempt of compromises to the mother and the conceptus.

Análise multivariada das atividades científicas e técnicas no processo de adoção de inovação em empresas sucroenergéticas do centro-oeste do estado de São Paulo

The primary objective of this study was to verify the existence of internal organization and processes influencing the decisions on adoption, choice, justification and implementation of innovative practices of scientific and technical activities undertaken in the elaborates of sugar, ethanol and energy companies of the midwest of the state of Sao Paulo. Using multivariate analysis of principal components and clusters, the variables were analyzed and the companies, classified. The taxonomy model adapted to contemporary situations described by Freeman (1975), was the 'parameter used with research information in personal interviews by semi-structured questionnaires. The investigated activities constituted of: basic research; applied research; experimental development; scientific and technical information; long-term planning. The variables analyzed were: production processes, operating systems, development of new products, projects and implementation of pilot plant for new products, development, knowledge, studies of other business segments, number of innovations, and the number of existing employees in the organizational structure for these purposes. It was concluded that the best companies with innovative attitudes are those that have incorporated into their organizational the structures, practices and techniques of scientific activities.

Análise multivariada na diferenciaçãoentre manejos de solos cultivados com café

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise Espacial Multivariada Aplicada na Avaliação da Fertilidade do Solo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Calibração e validação de um método de medida da radiação solar global por meio de actinógrafos baseada em técnicas de processamento de imagens digitais

O objetivo do trabalho é desenvolver um sistema informático de digitalização e processamento de actinogramas baseado em técnicas de Processamento de Imagens Digitais e comparar com o sistema tradicional de medidas. Os actinogramas foram fornecidos pela Estação Meteorológica de Botucatu (FCA/UNESP). As análises preliminares indicam um desempenho satisfatório do software proposto, gerando medidas na mesma ordem de grandeza do método de referência para partição diária. O software proposto pertence a um projeto que se encontra ainda em andamento, onde rotinas de técnicas diversas continuam sendo implementadas no reconhecimento da curva de interesse para melhorar a qualidade do processamento das informações gráficas dos actinogramas. Os actinogramas estão em fase de digitalização para que o software possa ser testado com uma base de dados mais consistente, onde poderão ser identificados tendências temporais dos dados resultantes da aplicação das técnicas de Processamento de Imagens Digitais no monitoramento da radiação solar por actinógrafos.