Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 52 - Grußschreiben des evangelischen Pfarrers Karl Candidus anlässlich der Übersetzung der "Welt als Wille und Vorstellung" ins Französische

u.a.: Gründe für die Bewunderung Schopenhauers; "Allgemeine Zeitung"; Immanuel Kant, Charles Secretan; S. Hirzel; Alexandre Weill;

Ms.Ff.F.Stoltze 3. 52 - Brief von Franz Fabricius an Friedrich Stoltze

Bitte um humoristischen Text, Weber: Familie, silberne Hochzeit

Inc. hebr. 52 - Talmud Bavli : Masekhet Betsah

Vorbesitzer: Abraham Merzbacher;

Na 1 Nachlass Max Horkheimer, 631 - Vorlesung "Über Philosophie der Gesellschaft im 17. und 18. Jahrhundert" und Aufsatz "Bemerkungen über Wissenschaft und Gesellschaft" für die Zeitschrift für Sozialforschung (p. VIII 52-IX.3)

"Über Philosophie der Gesellschaft im 17. und 18. Jahrhundert", Vorlesung oder Seminar in Chicago (?), Datierung unklar, eigenhändige Notizen, 1 Heft, 95 Blätter, davon 76 leer; "Bemerkungen über Wissenschaft und Gesellschaft" (GS 3, S. 40-47), veröffentlicht unter dem Titel "Bemerkungen über Wissenschaft und Krise", in: Zeitschrift für Sozialforschung I, 1932, S. 1-7, Typoskript mit eigenhändiger Korrektur, 11 Blatt; Exzerpte zum Thema "Materialismus und Metaphysik", veröffentlicht in: Zeitschrift für Sozialforschung II, 1933, S.1-33.; Diskussionsbeiträge auf dem XI. Internationalen Soziologenkongress in Genf, Oktober 1933, 1. "Zum Problem der Voraussage in den Sozialwissenschaften" (GS 3, S. 150-157), veröffentlicht in: Zeitschrift für Sozialforschung II, 1933, S. 407-412, a) französische Fassung, Typoskript mit eigenhändiger Korrektur, 8 Blatt, b) französische Fassung, Typoskript mit eigenhändiger Korrektur, 9 Blatt; 2. "Über Funktion und Grenzen der Statistik in den Sozialwissenschaften", französische Fassung, Typoskript mit eigenhändiger Korrektur, 5 Blatt; Exzerpt zu: G.L. Duprat, Typoskript, 1 Blatt; "Auszug aus den dem Kongreß von verschiedenen Teilnehmern vorgelegten Thesen", Typoskript, 3 Blatt; Kongreß-Programme, Drucksachen, 3 Blatt;

Ms. lat. oct. 52 - Responsionale secundum usum ecclesiae S. Bartholomaei Francfordensis

Die Foliierung geht nur bis Bl. 149; zusätzlich gibt es das Blatt 113a.

Tumor heterogeneity dictates sensitivity to gefitinib (Iressa(TM)/ZD1839) in solid tumor models

The epidermal growth factor receptor (EGFR) and its ligands are overexpressed in many human tumors, including bladder and pancreas, correlating with a more aggressive tumor phenotype and poor patient prognosis. We initiated the present study to characterize the heterogeneity of gefitinib responsiveness in a panel of human bladder and pancreatic cancer cell lines in order to identify the biological characteristics of EGFR-dependent proliferation that could be used to prospectively identify drug-sensitive tumors. A second objective was to elucidate how to best exploit these results by utilizing gefitinib in combination therapy. To these ends, we examined the effects of the EGFR antagonist gefitinib on proliferation and apoptosis in a panel of 18 human bladder cancer cell lines and 9 human pancreatic cancer cell lines. Our data confirmed the existence of marked heterogeneity in Iressa responsiveness with less than half of the cell lines displaying significant growth inhibition by clinically relevant concentrations of the drug. Gefitinib responsiveness was found to be p27 kip1 dependent as DNA synthesis was restored following exposure to p27siRNA. Unfortunately, Iressa responsiveness was not closely linked to surface EGFR or TGF-α expression in the bladder cancer cells, however, cellular TGF-α expression correlated directly with Iressa sensitivity in the pancreatic cancer cell lines. These findings provide the potential for prospectively identifying patients with drug-sensitive tumors. ^ Further studies aimed at exploiting gefitinib-mediated cell cycle effects led us to investigate if gefitinib-mediated TRAIL sensitization correlated with increased p27kip1 accumulation. We observed that increased TRAIL sensitivity following gefitinib exposure was not dependent on p27 kip1 expression. Additional studies initiated to examine the role(s) of Akt and Erk signaling demonstrated that exposure to PI3K or MEK inhibitors significantly enhanced TRAIL-induced apoptosis at concentrations that block target phosphorylation. Furthermore, combinations of TRAIL and the PI3K or MEK inhibitors increased procaspase-8 processing above levels observed with TRAIL alone, indicating that the effects were exerted at the level of caspase-8 activation, considered the earliest step in the TRAIL pathway. ^

Zircons, isotope ratios and element analyses from tonalite and oxide gabbro of the mid-ocean ridge from ODP Hole 176-735B

A limiting factor in the accuracy and precision of U/Pb zircon dates is accurate correction for initial disequilibrium in the 238U and 235U decay chains. The longest-lived-and therefore most abundant-intermediate daughter product in the 235U isotopic decay chain is 231Pa (T1/2 = 32.71 ka), and the partitioning behavior of Pa in zircon is not well constrained. Here we report high-precision thermal ionization mass spectrometry (TIMS) U-Pb zircon data from two samples from Ocean Drilling Program (ODP) Hole 735B, which show evidence for incorporation of excess 231Pa during zircon crystallization. The most precise analyses from the two samples have consistent Th-corrected 206Pb/238U dates with weighted means of 11.9325 ± 0.0039 Ma (n = 9) and 11.920 ± 0.011 Ma (n = 4), but distinctly older 207Pb/235U dates that vary from 12.330 ± 0.048 Ma to 12.140 ± 0.044 Ma and 12.03 ± 0.24 to 12.40 ± 0.27 Ma, respectively. If the excess 207Pb is due to variable initial excess 231Pa, calculated initial (231Pa)/(235U) activity ratios for the two samples range from 5.6 ± 1.0 to 9.6 ± 1.1 and 3.5 ± 5.2 to 11.4 ± 5.8. The data from the more precisely dated sample yields estimated DPazircon/DUzircon from 2.2-3.8 and 5.6-9.6, assuming (231Pa)/(235U) of the melt equal to the global average of recently erupted mid-ocean ridge basaltic glasses or secular equilibrium, respectively. High precision ID-TIMS analyses from nine additional samples from Hole 735B and nearby Hole 1105A suggest similar partitioning. The lower range of DPazircon/DUzircon is consistent with ion microprobe measurements of 231Pa in zircons from Holocene and Pleistocene rhyolitic eruptions (Schmitt (2007; doi:10.2138/am.2007.2449) and Schmitt (2011; doi:10.1146/annurev-earth-040610-133330)). The data suggest that 231Pa is preferentially incorporated during zircon crystallization over a range of magmatic compositions, and excess initial 231Pa may be more common in zircons than acknowledged. The degree of initial disequilibrium in the 235U decay chain suggested by the data from this study, and other recent high precision datasets, leads to resolvable discordance in high precision dates of Cenozoic to Mesozoic zircons. Minor discordance in zircons of this age may therefore reflect initial excess 231Pa and does not require either inheritance or Pb loss.

Geochemistry of the oldest Atlantic oceanic crust

Controversy has surrounded the issue of whether mantle plume activity was responsible for Pangaean continental rifting and massive flood volcanism (resulting in the Central Atlantic Magmatic Province or CAMP, emplaced around 200 Ma) preceding the opening of the central Atlantic Ocean in the Early Mesozoic. Our new Sr-Nd-Pb isotopic and trace element data for the oldest basalts sampled from central Atlantic oceanic crust by deep-sea drilling show that oceanic crust generated from about 160 to 120 Ma displays clear isotopic and chemical signals of plume contamination (e.g., 87Sr/86Sr(i) = 0.7032-0.7036, epsilonNd(t) =+6.2 to +8.2, incompatible element patterns with positive Nb anomalies), but these signals are muted or absent in crust generated between 120 and 80 Ma, which resembles young Atlantic normal mid-ocean ridge basalt. The plume-affected pre-120 Ma Atlantic crustal basalts are isotopically similar to lavas from the Ontong Java Plateau, and may represent one isotopic end-member for CAMP basalts. The strongest plume signature is displayed near the center of CAMP magmatism but the hotspots presently located nearest this location in the mantle reference frame do not appear to be older than latest Cretaceous and are isotopically distinct from the oldest Atlantic crust. The evidence for widespread plume contamination of the nascent Atlantic upper mantle, combined with a lack of evidence for a long-lived volcanic chain associated with this plume, leads us to propose that the enriched signature of early Atlantic crust and possibly the eruption of the CAMP were caused by a relatively short-lived, but large volume plume feature that was not rooted at a mantle boundary layer. Such a phenomenon has been predicted by recent numerical models of mantle circulation.