Incidence of debris discs around FGK stars in the solar neighbourhood

Context. Debris discs are a consequence of the planet formation process and constitute the fingerprints of planetesimal systems. Their counterparts in the solar system are the asteroid and Edgeworth-Kuiper belts. Aims. The aim of this paper is to provide robust numbers for the incidence of debris discs around FGK stars in the solar neighbourhood. Methods. The full sample of 177 FGK stars with d ��� 20 pc proposed for the DUst around NEarby Stars (DUNES) survey is presented. Herschel/PACS observations at 100 and 160 ��m were obtained, and were complemented in some cases with data at 70 ��m and at 250, 350, and 500 ��m SPIRE photometry. The 123 objects observed by the DUNES collaboration were presented in a previous paper. The remaining 54 stars, shared with the Disc Emission via a Bias-free Reconnaissance in IR and Sub-mm (DEBRIS) consortium and observed by them, and the combined full sample are studied in this paper. The incidence of debris discs per spectral type is analysed and put into context together with other parameters of the sample, like metallicity, rotation and activity, and age. Results. The subsample of 105 stars with d ��� 15 pc containing 23 F, 33 G, and 49 K stars is complete for F stars, almost complete for G stars, and contains a substantial number of K stars from which we draw solid conclusions on objects of this spectral type. The incidence rates of debris discs per spectral type are 0.26^+0.21_-0.14 (6 objects with excesses out of 23 F stars), 0.21^+0.17_-0.11 (7 out of 33 G stars), and 0.20^+0.14_-0.09 (10 out of 49 K stars); the fraction for all three spectral types together is 0.22^+0.08_-0.07 (23 out of 105 stars). The uncertainties correspond to a 95% confidence level. The medians of the upper limits of L_dust/L_��� for each spectral type are 7.8 �� 10^-7 (F), 1.4 �� 10^-6 (G), and 2.2 �� 10^-6 (K); the lowest values are around 4.0 �� 10^-7. The incidence of debris discs is similar for active (young) and inactive (old) stars. The fractional luminosity tends to drop with increasing age, as expected from collisional erosion of the debris belts.

Differences in pelvic floor morphology between continent, stress urinary incontinent, and mixed urinary incontinent elderly women : an MRI study

Aims To compare magnetic resonance imaging (MRI) of the pelvic floor musculature (PFM), bladder neck and urethral sphincter morphology under three conditions (rest, PFM maximal voluntary contraction (MVC), and straining) in older women with symptoms of stress (SUI) or mixed urinary incontinence (MUI) or without incontinence. Methods This 2008���2012 exploratory observational cohort study was conducted with community-dwelling women aged 60 and over. Sixty six women (22 per group), mean age of 67.7��������5.2 years, participated in the study. A 3���T MRI examination was conducted under three conditions: rest, PFM MVC, and straining. ANOVA or Kruskal���Wallis tests (data not normally distributed) were conducted, with Bonferroni correction, to compare anatomical measurements between groups. Results Women with MUI symptoms had a lower PFM resting position (M-Line P���=���0.010 and PC/H-line angle P���=���0.026) and lower pelvic organ support (urethrovesical junction height P���=���0.013) than both continent and SUI women. Women with SUI symptoms were more likely to exhibit bladder neck funneling and a larger posterior urethrovesical angle at rest than both continent and MUI women (P���=���0.026 and P���=���0.008, respectively). There were no significant differences between groups on PFM MVC or straining. Conclusions Women with SUI and MUI symptoms present different morphological defects at rest. These observations emphasize the need to tailor UI interventions to specific pelvic floor defects and UI type in older women.

Stewardship antibiotica neonatale: valutazione dell'esposizione antimicrobica nelle sospette early onset sepsis (EOS)

Background: Le early-onset sepsis (EOS) sono infezioni batteriche invasive definite dalla presenza di batteri nel sangue e/o nel liquor cefalorachidiano che esordiscono nelle prime 72 ore di vita e causano in epoca neonatale mortalit�� e morbilit�� importanti. Scopo: Determinare l���eccesso di trattamento antibiotico (Overtreatment index=OI) nei neonati di EG ���34 settimane con sospetta sepsi ad esordio precoce. Metodi: Tutti i nati dal 1.01.2014 al 31.12.2018 di EG ���34 settimane presso IRCCS Azienda Ospedaliero-Universitaria e l���Ospedale Maggiore di Bologna che hanno ricevuto terapia antibiotica endovenosa nelle prime 168 ore di vita nel sospetto di EOS. Sono stati identificati 2 gruppi: EOS provata (N=7) ed EOS sospetta (N=465). Risultati: L���incidenza di EOS �� stata 0.22 su 1000 nati vivi, rispettivamente 0.12/1000 per Streptococcus agalactiae (GBS) e 0.06/1000 per Escherichia coli (E.coli). L���1.75% dei neonati ha ricevuto terapia antimicrobica empirica a largo spettro. L���OI �� risultato 68. L���esposizione al trattamento antibiotico nella popolazione �� stata di 85 giorni/1000 nati vivi. Tra i fattori di rischio materni, il tampone vagino-rettale (TVR) e l���urinocoltura positiva sono risultati associati al rischio di EOS provata (p=.017, p =.000). I valori di proteina C reattiva (PCR) al T0, T1 e T2 tra i due gruppi sono risultati significativi (p=.000). All���analisi multivariata �� stata confermata la significativit�� delle variabili descritte. (TVR non noto OR=15.1, 95%CI 1.98-115.50, p =.009, urinocoltura positiva OR=30.1, 95%CI 3.6-252.1, p = .002, PCR T0 OR=1.6, 95% CI 1.29-2.07, p = .000.) Conclusioni: L���individuazione precoce di fattori di rischio e la valutazione degli indici di flogosi in neonati sintomatici pu�� ridurre l���OI e la durata della terapia antibiotica in casi di sepsi non confermata. L���uso appropriato degli antibiotici in questa popolazione �� particolarmente importante poich�� riduce lo sviluppo di germi multiresistenti. Nelle Terapie Intensive Neonatali, i programmi di stewardship antimicrobica dovrebbero guidare la gestione delle sepsi.

Metodi numerici per la funzione segno di matrice

Per funzioni di matrice intendiamo generalizzazioni di funzioni scalari che permettono di valutare tali funzioni anche per matrici. Esistono numerosi esempi notevoli di funzioni di matrice: tra queste la funzione esponenziale, la radice quadrata e il segno. Quest'ultima �� particolarmente utile per la risoluzione di particolari equazioni matriciali come ad esempio le equazioni di Sylvester e le equazioni di Riccati. In questo elaborato introdurremo il concetto di funzione di matrice per poi soffermarci proprio sulla funzione segno. Oltre che a fornire tutte le definizioni necessarie e analizzare le propriet�� che ci aiuteranno a comprendere meglio questa funzione, ci interesseremo all'implementazione di algoritmi che possano calcolare o approssimare la funzione segno di matrice. Un primo metodo sfrutter�� la decomposizione di Schur: supponendo di conoscere la decomposizione della matrice, e di trovarci in algebra esatta, questo metodo non fornir�� un'approssimazione del segno della suddetta matrice ma l'esatto segno della stessa. Il secondo metodo che studieremo si pu�� definire pi�� come una famiglia di metodi. Vedremo infatti tre algoritmi diversi che per�� sfruttano tutti l'iterazione di Newton, opportunamente adattata al caso matriciale: il metodo di base, convergente globalmente, in cui applicheremo semplicemente questa iterazione, ed altri due che mireranno a risolvere problemi distinti del metodo di base, ovvero il numero di iterazioni necessarie per giungere alla convergenza (introducendo il concetto di riscaling) e l'alto costo computazionale (sacrificando per�� la convergenza globale). Grazie all'aiuto di Matlab analizzeremo pi�� nello specifico l'efficienza dei vari algoritmi descritti, ed infine vedremo pi�� nello specifico come utilizzare la funzione segno di matrice per risolvere le equazioni algebriche di Sylvester e di Riccati.

Telemonitoraggio dei dispositivi cardiaci impiantabili per la predizione dello scompenso

L'insufficienza cardiaca �� una delle malattie cardiovascolari pi�� comuni, nonch�� quella con maggiori tassi di riospedalizzazione. Nonostante numerosi pazienti siano sottoposti a impianto di defibrillatori cardiaci, come pacemaker e ICD, questo non �� sufficiente a diminuire i casi di ricovero. L'innovazione tecnologica dei dispositivi impiantabili li ha resi compatibili con l'utilizzo del monitoraggio remoto che avviene attraverso la trasmissione di un enorme quantit�� di dati eterogenei, noti come Big Data. Questi offrono la possibilit�� di rilevare numerosi parametri da cui �� possibile valutare il funzionamento del dispositivo e implementare algoritmi di medicina predittiva. In questo elaborato sono analizzati quattro casi studio (cardioMEMS, TRIAGE-HF, SELENE HF, multiSENSE), con lo scopo di confrontare gli algoritmi predittivi in essi sviluppati. Da questi studi, condotti su un insieme ristretto di campioni, �� emerso che lo scompenso �� predetto correttamente, ma con una previsione di riospedalizzazione a seguito di intervento che differisce in ogni studio clinico. Nello studio MultiSENSE, l'algoritmo ha previsto il 70% delle ospedalizzazioni, con un tempo medio di rilevamento di 34 giorni e 1,47 allarmi inspiegabili per anno-paziente. Questo rispetto al 65,5% e a un tempo medio di 42 giorni e rispetto a 0,63 allarmi inspiegabili per anno-paziente, nel SELENE HF. Nel caso del Triage-HF il tasso di ospedalizzazione �� dello 0,2% per anno-paziente, in quanto lo studio �� basato sull'associazione tra l'algoritmo e i sintomi che caratterizzano lo scompenso. Al contrario degli altri studi, lo studio cardioMEMS si �� occupato di sviluppare una nuova tecnologia: un dispositivo wireless impiantabile; infatti, risulta l'unico studio con un monitoraggio remoto invasivo. Considerando la presenza di numerosi gradi di peggioramento dello scompenso e di differenti dispositivi impiantabili cardiaci �� difficile creare un unico algoritmo che includa tutte le tipologie di pazienti.

Association Between Prehypertension, Metabolic And Inflammatory Markers, Decreased Adiponectin And Enhanced Insulinemia In Obese Subjects.

Obesity is associated with development of the cardiorenal metabolic syndrome, which is a constellation of risk factors, such as insulin resistance, inflammatory response, dyslipidemia, and high blood pressure that predispose affected individuals to well-characterized medical conditions such as diabetes, cardiovascular and kidney chronic disease. The study was designed to establish relationship between metabolic and inflammatory disorder, renal sodium retention and enhanced blood pressure in a group of obese subjects compared with age-matched, lean volunteers. The study was performed after 14��h overnight fast after and before OGTT in 13 lean (BMI 22.92��������2.03��kg/m(2)) and, 27 obese (BMI 36.15��������3.84��kg/m(2)) volunteers. Assessment of HOMA-IR and QUICKI index were calculated and circulating concentrations of TNF-��, IL-6 and C-reactive protein, measured by immunoassay. THE STUDY SHOWS THAT A HYPERINSULINEMIC (HI: 10.85��������4.09����g/ml) subgroup of well-characterized metabolic syndrome bearers-obese subjects show higher glycemic and elevated blood pressure levels when compared to lean and normoinsulinemic (NI: 5.51��������1.18����g/ml, P���<���0.027) subjects. Here, the combination of hyperinsulinemia, higher HOMA-IR (HI: 2.19��������0.70 (n���=���12) vs. LS: 0.83��������0.23 (n���=���12) and NI: 0.98��������0.22 (n���=���15), P���<���0.0001) associated with lower QUICKI in HI obese when compared with LS and NI volunteers (P���<���0.0001), suggests the occurrence of insulin resistance and a defect in insulin-stimulated peripheral action. Otherwise, the adiponectin measured in basal period was significantly enhanced in NI subjects when compared to HI groups (P���<���0.04). The report also showed a similar insulin-mediated reduction of post-proximal urinary sodium excretion in lean (LS: 9.41��������0.68% vs. 6.38��������0.92%, P���=���0.086), and normoinsulinemic (NI: 8.41��������0.72% vs. 5.66��������0.53%, P���=���0.0025) and hyperinsulinemic obese subjects (HI: 8.82��������0.98% vs. 6.32��������0.67%, P���=���0.0264), after oral glucose load, despite elevated insulinemic levels in hyperinsulinemic obeses. In conclusion, this study highlights the importance of adiponectin levels and dysfunctional inflammatory modulation associated with hyperinsulinemia and peripheral insulin resistance, high blood pressure, and renal dysfunction in a particular subgroup of obeses.

Influ��ncia do aux��lio mec��nico na colheita de tomates

Fresh tomato harvest is traditionally made without harvesting aids. The main goal of this research was to evaluate performance parameters of fresh tomato harvesting aid equipment and compare it to traditional harvest, in the state of S��o Paulo. Therefore, an equipment was developed and the harvest process was evaluated in four different ways: traditional system (harvest system used in Santa Luzia farm, Brotas, SP, Brazil), picker walking with a harvesting aid equipment, picker seated in a harvesting aid equipment and a composition of both systems: two pickers seated and one picker walking in two different velocities ranges. The different systems using harvesting aid showed an average yield by picker more efficient than reference. Harvest system using three pickers showed an increase of 290% on yield average by picker, on the range of 0.5-1.0 fruit per plant, followed by the systems with a walking picker, that increased productivity in 41%, and picker seated harvester, that showed an increase of 35%. These results demonstrate the importance of using a harvesting aid equipment.

Metformina interage com o treinamento f��sico diminuindo a glicemia e aumentando o armazenamento de glicog��nio em ratos diab��ticos

INTRODUCTION: Like in humans, lower amounts of glycogen are present in tissues of diabetic rats. However, training or drugs that lower glycemia can improve the metabolic control. Metformin increased glycogen while decreased glycemia in normal rats stressed by exercise. OBJECTIVE: In this work we investigated if regular exercise and metformin effects improve the metabolism of diabetic rats. METHODS: Alloxan diabetic Wistar rats treated with metformin (DTM) or not (DT) were trained. Training consisted of 20 sessions of 30 min, 5 days a week. Sedentary diabetic rats served as control (SD and SDM). Metformin (5.6 ��g/g) was given in the drinking water. After 48 h resting, glucose (mg/dl) and insulin (ng/mL) was measured in plasma and glycogen (mg/100 mg of wet tissue) in liver, soleus and gastrocnemius. RESULTS: Glycemia decreased in DM group from 435��15 to 230��20, in DT group to 143��8.1 and in DTM group to 138��19 mg/dl. DM group had proportional increase in the hepatic glycogen from 1.69��0.22 to 3.53��0.24, and the training increased to 3.36 �� 0.16 mg/100 mg. Metformin induced the same proportional increase in the muscles (soleus from 0.21��0.008 to 0.42��0.03 and gastrocnemius from 0.33��0.02 to 0.46��0.03), while the training promoted increase on gastrocnemius to 0,53 �� 0,03, only. A high interaction was observed in liver (glycogen increased to 6.48��0.34). CONCLUSION: Very small oral doses of metformin and/or, partially restored glycemia in diabetic rats and decreased glycogen in tissues. Its association with an exercise program was beneficial, helping lower glycemia further and increase glycogen stores on liver of diabetic rats.

CARACTER��STICAS DE QUALIDADE DO CONTRAFIL�� (m. L. dorsi) DE TOUROS JOVENS DA RA��A NELORE

Quality traits of boneless rib cut (L. dorsi muscle) from Nelore young bulls. To study the meat quality traits of Nelore breed young bulls, and the effect of age (690-780 days) on them, 113 animals were slaughtered after 109 days of intensive feeding with 20% concentrate and 80% roughage. All the carcasses were graded at the slaughter floor by the Federal Inspection and chilled for 24 hours (Tinitial=5��C, Tfinal=2��C). Fifty one half carcasses (right side), type B - B R A S I L `s grading system - from animals of 23 to 26 months were boned and separated into commercial cuts. Two steaks (2.5cm thick) were removed from each boneless rib cut (m. L. dorsi), vacuum packaged and aged for 7 days (0-2��C). The pH varied from 5.44 to 5.83 and only two samples had pH �� 5.70. The L* (brightness) average value was 34.85. The water and fat content were 75.65% and 1.71%, respectively. The average WB shear force was 6.70kg, and it was not affected by age (690-734 days), but presented a trend (t test, p=0.22) for increasing values between 735 and 780 days. Animal age did not affect other quality traits (t test, p&gt;0.20). It was concluded that the rib cut from Nelore young bulls may not have a good acceptability in exigent markets, and that carcasses graded B, presumed to be the best grade, do not necessarily present the best meat quality characteristics.

Programa preventivo da c��rie dent��ria baseado no controle mec��nico da placa bacteriana em crian��as, por meio da profilaxia profissional peri��dica: Resultados ap��s 25 anos de acompanhamento

OBJETIVOS: o objetivo deste trabalho foi verificar a incid��ncia de c��rie dent��ria em um programa de preven����o aplicado durante 25 anos em cl��nica particular. METODOLOGIA: participaram desse programa 640 crian��as de ambos os g��neros, na faixa et��ria de 3 a 15 anos de idade. O programa foi baseado no controle mec��nico da placa bacteriana dent��ria por meio da profilaxia profissional com jato de bicarbonato de s��dio com uma periodicidade mensal. A incid��ncia de c��rie foi verificada por meio de exames cl��nicos durante as sess��es de atendimento e radiogr��ficos anualmente. A m��dia de idade das crian��as ao ingressarem no programa foi de 7,8 anos. RESULTADOS: antes de ingressar no programa, as crian��as apresentaram, em m��dia, 5,3 faces cariadas, enquanto ap��s o programa a m��dia foi de 0,18. A incid��ncia de c��ries por ano antes do programa foi de 0,9 faces cariadas e durante o programa de 0,03. O tempo de perman��ncia das crian��as no programa foi, em m��dia, de 52,6 meses, e a m��dia de faltas foi de 0,5 falta por ano. Esses resultados demonstram o sucesso do programa, principalmente por ter uma filosofia que procura o equil��brio da biodiversidade da cavidade bucal, sem o risco de produzir efeitos colaterais indesej��veis. CONCLUS��ES: conclui-se, assim, que esse parece ser o caminho mais curto para resolver o problema da c��rie dent��ria, ou seja, o controle mec��nico da placa bacteriana dent��ria atrav��s da profilaxia profissional mensal, pois �� um m��todo de preven����o poss��vel de ser aplicado em qualquer crian��a, independentemente de suas condi����es psicomotoras e sociais, e que proporciona a melhor rela����o custo-benef��cio, al��m de estar de acordo com os conceitos mais atuais de c��rie e de seus fatores etiol��gicos. Em fun����o da faixa et��ria das crian��as, o programa �� de suma import��ncia para cl��nicas de Odontopediatria e Ortodontia.

Effectiveness of different final irrigation protocols in removing debris in flattened root canals

This study evaluated in vitro the capacity of debris removal from the apical third of flattened root canals, using different final irrigation protocols. Thirty human mandibular central incisors with a mesiodistal flattened root were prepared using rotary instrumentation by Endo-Flare 25.12 and Hero 642 30.06, 35.02, 40.02 files, irrigated with 2 mL of 1% NaOCl after each file. The specimens were randomly distributed into 5 groups according to the final irrigation of root canals: Group I: 10 mL of distilled water (control), Group II: 10 mL of 1% NaOCl for 8 min, Group III: 2 mL of 1% NaOCl for 2 min (repeated 4 times), Group IV: 10 mL of 2.5% NaOCl for 8 min, and Group V: 10 mL of 2.5% NaOCl for 2 min (repeated 4 times). The apical thirds of the specimens were subjected to histological processing and 6-&#956;m cross-sections were obtained and stained with hematoxylin-eosin. The specimens were examined under optical microscopy at ��40 magnification and the images were subjected to morphometric analysis using the Scion image-analysis software. The total area of root canal and the area with debris were measured in square millimeters. Analysis of variance showed no statistically significant difference (p>0.05) among the groups GI (2.39 �� 3.59), GII (2.91 �� 2.21), GIII (0.73 �� 1.36), GIV (0.95 �� 0.84) and GV (0.51 �� 0.22). In conclusion, the final irrigation protocols evaluated in this study using the Luer syringe presented similar performance in the removal of debris from the apical third of flattened root canals.

Study of the surface hardness and modulus of elasticity of conventional and microwave-cured acrylic resins

The aim of this study was to evaluate the following acrylic resins: Cl��ssico��, QC-20�� and Lucitone��, recommended specifically for thermal polymerization, and Acron MC�� and VIPI-WAVE��, made for polymerization by microwave energy. The resins were evaluated regarding their surface nanohardness and modulus of elasticity, while varying the polymerization time recommended by the manufacturer. They were also compared as to the presence of water absorbed by the samples. The technique used was nanoindentation, using the Nano Indenter XP��, MTS. According to an intra-group analysis, when using the polymerization time recommended by the manufacturer, a variation of 0.14 to 0.23 GPa for nanohardness and 2.61 to 3.73 GPa for modulus of elasticity was observed for the thermally polymerized resins. The variation for the resins made for polymerization by microwave energy was 0.15 to 0.22 GPa for nanohardness and 2.94 to 3.73 GPa for modulus of elasticity. The conclusion was that the Classico�� resin presented higher nanohardness and higher modulus of elasticity values when compared to those of the same group, while Acron MC�� presented the highest values for the same characteristics when compared to those of the same group. The water absorption evaluation showed that all the thermal polymerization resins, except for Lucitone��, presented significant nanohardness differences when submitted to dehydration or rehydration, while only Acron MC�� presented no significant differences when submitted to a double polymerization time. Regarding the modulus of elasticity, it was observed that all the tested materials and products, except for Lucitone��, showed a significant increase in modulus of elasticity when submitted to a lack of hydration.

Avalia����o gen��tica multirracial para ganho de peso pr��-desmama em bovinos de uma popula����o composta

Objetivou-se neste trabalho estudar modelos com efeitos n��o-aditivos diretos e maternos em uma popula����o composta em clima tropical, tentando minimizar esses efeitos para obten����o dos valores gen��ticos dos animais avaliados. Foram utilizados dados de animais de uma popula����o composta, por meio da compara����o de tr��s modelos que inclu��ram os efeitos fixos de grupo contempor��neo, ordem de parto e heterose direta e materna e os efeitos aleat��rios de efeito gen��tico aditivo direto e materno. As an��lises foram realizadas em duas etapas; na primeira foram estudadas as estimativas dos efeitos raciais e de heterose individual e materna e na segunda etapa, calculadas as vari��ncias, herdabilidades e os valores gen��ticos dos animais. O efeito materno, quando n��o foi considerado no modelo, pareceu superestimar o efeito aditivo racial. Os efeitos aditivos raciais, racial materno e de heterose individual e materna influenciaram significativamente o ganho m��dio di��rio no pr��-desmame, obtendo-se diferentes estimativas entre os tipos biol��gicos. Considerando o arquivo de dados corrigidos para os efeitos n��o-aditivos diretos e maternos, as herdabilidades direta e materna foram de 0,22 e 0,20, respectivamente. Os efeitos racial materno e de heterose individual e materna foram importantes fontes de varia����o para o ganho m��dio di��rio no pr��-desmame e devem ser considerados durante a avalia����o gen��tica de uma popula����o multirracial.

Efeitos de dietas com n��veis crescentes de milho no metabolismo ruminal de energia e prote��na em bubalinos

Avaliaram-se os efeitos de dietas com n��veis crescentes de milho em gr��o mo��do (0, 22, 37 e 49% na MS) em substitui����o ao feno de coast-cross mantendo-se diferentes rela����es prote��na:carboidratos n��o-fibrosos (PB:CNF = 1,01; 0,39; 0,33 e 0,27) sobre o metabolismo ruminal de b��falos. Utilizaram-se quatro b��falos fistulados no r��men, mantidos em delineamento quadrado latino 4 &#215; 4, para a coleta de amostras do l��quido ruminal, colhidas em cada per��odo experimental (de 28 dias) nos tempos 0, 2, 4 e 8 horas ap��s a alimenta����o. Em geral, os bubalinos apresentaram boa capacidade tamponante no r��men, com pH m��dio alto (6,70) e aumento da ingest��o de milho em gr��o mo��do. O acr��scimo nos n��veis de milho na dieta promoveu aumento da produ����o de ��cido but��rico. Somente a dieta com 49% de milho promoveu melhor fermenta����o ruminal, com menor propo����o de ��cidos ac��tico:propi��nico. A rela����o PB:CNF de 1,01 indica defici��ncia de energia da dieta dispon��vel para microrganismos no r��men ao longo do dia, enquanto dietas com PB:CNF entre 0,39 e 0,27 promovem fermenta����es ruminais semelhantes, o que indica sincronismo na utiliza����o de nitrog��nio e energia pelos microrganismos no r��men nessas condi����es.

Anticorpos contra LDL-ox e s��ndrome coronariana aguda

FUNDAMENTO: A oxida����o da lipoprote��na de baixa densidade (LDL-ox) induz �� forma����o de ep��topos imunog��nicos na mol��cula. A presen��a de autoanticorpos contra a LDL-ox tem sido demonstrada no soro de pacientes com doen��a arterial coronariana (DAC). Contudo, o papel desses autoanticorpos na fisiopatologia das s��ndromes coronarianas agudas (SCA) e o seu significado cl��nico permanecem indefinidos. OBJETIVO: Avaliar a associa����o entre autoanticorpos contra a LDL-ox e SCA. M��TODOS: Os t��tulos de imunoglobulina G autoanticorpos contra a LDL-ox por cobre (antiLDL-ox) e contra o pept��deo sint��tico D derivado da apolipoprote��na B (antipeptD) foram determinados por ensaio imunoenzim��tico (ELISA) em 90 pacientes, nas primeiras 12h de SCA (casos) e em 90 pacientes com DAC cr��nica (controles). RESULTADOS: Os resultados mostraram que os t��tulos de antiLDL-ox foram significativamente mais elevados (p = 0,017) nos casos (0,40 �� 0,22), do que nos controles (0,33 �� 0,23). Por outro lado, os t��tulos de antipeptD foram significativamente menores (p < 0,01) nos casos (0,28 �� 0,23) do que nos controles (0,45 �� 0,30). A diferen��a dos t��tulos de ambos anticorpos entre os dois grupos estudados foi independente de idade, sexo, hipertens��o arterial, diabete melito, dislipidemia, ��ndice de massa corporal, tabagismo, perfil lip��dico, uso de estatinas e hist��ria familiar de DAC. CONCLUS��O: Os resultados mostraram que os t��tulos de antiLDL-ox foram significativamente mais elevados nos pacientes com s��ndrome coronariana aguda quando comparados aos pacientes com doen��a arterial coronariana e podem estar associados �� instabilidade da placa ateroscler��tica.