Policies for the management of the development of river basins and microregions in the high Andes

Includes bibliography

The metal exchanges and their incidence in the development of mining in Latin America and the Caribbean

Includes bibliography

El desarrollo del transporte público urbano en América Latina y el mundo = The development of urban public transport in Latin America and the world

Incluye Bibliografía

Consultancy study for the development of a strategy for institutionalizing the gender perspective in the substantive work of ECLAC

Includes bibliography

Brief history of the IDRC-CELADE relationship in the development of the Latin American Population Documentation System (DOCPAL)

El documento contiene una breve resena sobre las relaciones entre el IDRC y CELADE con miras al desarrollo del sistema latinoamericano de documentacion en poblacion (DOCPAL)

Policies and instruments for the development of non-traditional exports: analysis and evaluation of CARIFTA countries

Includes bibliography

The use of databases of social and gender statistics in the development of policies and programmes

The unavailability of data to inform policy planning and formulation has been repeatedly cited as the main challenge to economic and social progress in the Caribbean. Furthermore, even in instances when data is produced, broader gaps exist between its production and eventual use for evidence-based policy formulation. Owing to those challenges, this report explores the use of databases of social and gender statistics in the development of policies and programmes in the Caribbean subregion. The report offers a general appraisal of databases against two main considerations: (i) maximizing the use of existing databases in relevant policies and programmes; and (ii) bridging the gaps in data availability of relevant statistical databases and their analyses. The assessment entailed an inventory of social and gender databases maintained by data producers in the region and analysis of the extent to which the databases are used for policy formulation. To that end, a literature search as well as consultations with a number of knowledgeable persons active in the field of statistics and data provision was conducted. Based on the review, a set of recommendations were produced to improve current practices within the region with respect evidence based policy formulation.

Employing knowledge networks as tools for the development of Caribbean Small Island Developing States

Expertise, skills, experiences, understandings and capabilities (knowledge) aid development, not just by informing decision-making, but also by providing ideas for actions and activities that can be taken. Due to their size, and economic and environmental vulnerabilities, Caribbean Small Island developing States (SIDS) faces special challenges when working towards their economic, social and environmental development goals. These challenges have contributed to the creation of knowledge gaps, and that which is already available is located in isolated pockets, throughout the Caribbean. Migration of skilled persons compounds the issue, thereby removing much needed knowledge to beyond the traditional borders of the Caribbean. It is necessary to find ways to connect these dispersed knowledge resources. Knowledge networks are tools that can connect the existing skills, expertise, experiences and understandings accessible and create new ones to move towards greater development in the Caribbean. The purpose of this paper is to explore and highlight the role that knowledge networks can play as an aid in the development of Caribbean SIDS. It offers, with Caribbean examples, definitions and discussions of the components, types, and the advantages and disadvantages they hold for the subregion. The paper goes further to provide some ideas on assembling and analysing the different types of knowledge networks. It concludes with a few recommendations geared toward improving the availability of knowledge in the Caribbean.

Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells

The influence of melatonin on the developmental pattern of functional nicotinic acetylcholine receptors was investigated in embryonic 8-day-old chick retinal cells in culture. The functional response to acetylcholine was measured in cultured retina cells by microphysiometry. The maximal functional response to acetylcholine increased 2.7 times between the 4th and 5th day in vitro (DIV4, DIV5), while the Bmax value for 125I-a-bungarotoxin was reduced. Despite the presence of a8-like immunoreactivity at DIV4, functional responses mediated by a-bungarotoxin-sensitive nicotinic acetylcholine receptors were observed only at DIV5. Mecamylamine (100 µM) was essentially without effect at DIV4 and DIV5, while dihydro-ß-erythroidine (10-100 µM) blocked the response to acetylcholine (3.0 nM-2.0 µM) only at DIV4, with no effect at DIV5. Inhibition of melatonin receptors with the antagonist luzindole, or melatonin synthesis by stimulation of D4 dopamine receptors blocked the appearance of the a-bungarotoxin-sensitive response at DIV5. Therefore, a-bungarotoxin-sensitive receptors were expressed in retinal cells as early as at DIV4, but they reacted to acetylcholine only after DIV5. The development of an a-bungarotoxin-sensitive response is dependent on the production of melatonin by the retinal culture. Melatonin, which is produced in a tonic manner by this culture, and is a key hormone in the temporal organization of vertebrates, also potentiates responses mediated by a-bungarotoxin-sensitive receptors in rat vas deferens and cerebellum. This common pattern of action on different cell models that express a-bungarotoxin-sensitive receptors probably reflects a more general mechanism of regulation of these receptors.

Green chromatographic fingerprinting: An environmentally friendly approach for the development of separation methods for fingerprinting complex matrices

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)