Estudo dos compostos voláteis da decomposição térmica dos anti-helmínticos Albendazol e Mebendazol

The albendazole and mebendazole drugs are benzimidazole derivatives and belong to the anthelmintic class. These drugs are particularly recommended for the treatment against worms present in the gastrointestinal tract of animals and humans, by acting directly on the worm metabolism. The need for thermally study drugs is related to all the parameters that these analyzes include: presence or absence of polymorphs, possible changes in the crystallinity of the drugs, as well as the quality control during the manufacturing process thereof. In this study the thermal behavior of anthelmintic albendazole and commercial mebendazole and its recrystallisation in organic solvents, such as acetic acid and formic acid in dimethylformamide to mebendazole, and albendazole were studied using TG-DSC techniques, TG-FTIR, FTIR and XRD. TG-DSC techniques were used so it could collect information about the thermal stability of the compounds steps for thermal decomposition process and also prove its melting temperature. For recrystallization of drugs in organic solvents, the TG-DSC curves were analyzed to compare and determine that the occurrence of polymorphs. The coupled TG-FTIR technique allowed the analysis of volatile products which were released during the thermal decomposition of the commercial mebendazole. The absorption spectroscopy in the infrared region was performed to mebendazole, and albendazole in order to show the difference in functional groups of both, comparing the spectra with commercial drugs and see if there was recrystallized changes in the absorption band where the drug was recrystallized or when heated. The diffraction technique by powder X-ray method was used for comparison of the crystal structures of commercial drugs and recrystallization in organic solvents to identify changes in crystallinity both, which might suggest the formation of polymorphs

Mapeamento dos compartimentos de relevo do município de Estrela do Norte-SP e adjacências

The Geomorphology is to study the relevant object, which is the substrate where there are social relations, where society draws the natural resources for their survival and structure its immediate surroundings. In this context, the geomorphological map is currently considered as an important tool in landscape research. The landscapes of the city of Estrela do Norte-SP and surroundings consist mostly of geological substratum of sedimentary rock formations of Adamantina and Santo Anastácio (IPT, 1981a). Geomorphologically dominated by large reliefs of gently rolling hills tops and pedologicamente, the Oxisols and Ultisols Red-Yellow (Oliveira et al., 1999), which historically without proper management, formed a serious degradation of erosive framework in the study area. Thus, this study aimed to produce a map of the major compartments of the municipality Estrela do Norte-SP and surrounding areas, using techniques of digital stereoscopy. In relation to the procedures used in developing the mapping of geomorphological compartments, the main references were Tricart (1965) and Ross (1992). To prepare the mapping applied to refund technique - 3D through the ALOS / PRISM images...

Calcários albianos de campo petrolífero na Bacia de Campos: fácies, diagênese e modelo deposicional

Pós-graduação em Geologia Regional - IGCE

Pantanal: fauna, flora e paisagens

Pós-graduação em Ciências Biológicas (Zoologia) - IBB

Análise da suscetibilidade do meio físico a movimentos gravitacionais de massa por meio de sistematização de zoneamento geoambiental

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Elementos estruturais relacionados com a mineralização do eoceno - oligoceno entre Mollebamba e Santo Domingo região de Apurimac, sul do Peru

Pós-graduação em Geociências e Meio Ambiente - IGCE

Determinação das melhores condições de hidrólise física com ultrassom de potência em resíduos de amendoim

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise estratigráfica em depósitos lacustres maastrichtianos da Formação Yacoraite (Bacia de Salta - Argentina): definição e rastreabilidade de sequências de alta resolução

Pós-graduação em Geologia Regional - IGCE

Modelo deposicional de carbonatos albianos da Formação Quissamã: análise faciológica, diagenética e estratigráfica de um campo de óleo na porção meridional da Bacia de Campos

Pós-graduação em Geologia Regional - IGCE

Potencial geoparque do polo turístico das Águas de São Lourenço - Mato Grosso

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Análise da suscetibilidade a corridas de massa aplicada a dutovias: estudo de caso na bacia do Ribeirão do Roque

This scientific research aimed at to analyse the susceptibility to debris flow of the watershed of Ribeirão do Roque (SP), focusing on the upstream areas of OSBRA pipeline. This is because, mass flow can cause damage to pipes, mainly due to conditioning hydro erosion of the land in the drainage crossings, including the undermining the banks of streams. Firstly, It was conducted a literature review, aiming to identify and understand the principal characteristics and conditions of debris flow. Secondly, the physical and anthropic factors and their respective weights of influence were selected and used to determine the mass flow susceptibility. It was selected the following physical factors: type and thickness of rocks, soil and unconsolidated materials; textural density; amplitude relief; relief slope; shaped valley; and shape of slopes. Such factors are present in the physiographic subdivision map of the study area. In addition, the anthropic attributes correspond to the classes contained in the land use map. Therefore, the physical and anthropic factors were integrated through the multi-criteria analysis in a GIS environment, generating a total susceptibility map of debris flow on the scale 1:50,000. The results showed that a significative part of the study area was classified as average susceptibility. However, it was identified areas with high susceptibility in the region in which the pipe cross the Ribeirão do Roque. Moreover, at which point the river presents a closed valley and a meander shape, without a fluvial plain that would be useful to attenuate the development of the process. Consequently, if a mass flow begins in any of these most susceptible regions located upstream of the pipe, the chances that the process develops by the river and causes the excavations of his bed are quite large. However, the pipelines cross these critical areas directly on the rock (diabase), which provides additional protection against possible ...

Técnica híbrida de plasma para a deposição de filmes de alumina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Simulação computacional por elementos finitos de múltiplas fissuras em sólidos usando técnica de fragmentação da malha

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Características químico-mineralógicas e cerâmicas da matéria-prima utilizada pelo polo cerâmico de Rio Verde de Mato Grosso, MG

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Prospecção geofísica entre as ocorrências cupríferas Capão Grande e Victor Teixeira, Caçapava do Sul - RS

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)