ABD e-News October 17, 2003

Weekly newsletter for the State of Iowa Alcoholic Beverages Division

IDED Tools and Trends, January 2002, Issue 17

Newsletter for Economic Development

M. Barthou, 17-1-20, Congrès de Versailles : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57681

17-1-20, Congrès de Versailles : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57677

Arrivée de M. Briand [Aristide] 17-1-20, Congrès de Versailles : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57694

Colombes, 17/2/20, match France contre Pays de Galles [rugby, cérémonie d'avant-match, équipe de France] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58071

Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

Through their capacity to sense danger signals and to generate active interleukin-1β (IL-1β), inflammasomes occupy a central role in the inflammatory response. In contrast to IL-1β, little is known about how IL-1α is regulated. We found that all inflammasome activators also induced the secretion of IL-1α, leading to the cosecretion of both IL-1 cytokines. Depending on the type of inflammasome activator, release of IL-1α was inflammasome dependent or independent. Calcium influx induced by the opening of cation channels was sufficient for the inflammasome-independent IL-1α secretion. In both cases, IL-1α was released primarily in a processed form, resulting from intracellular cleavage by calpain-like proteases. Inflammasome-caspase-1-dependent release of IL-1α and IL-1β was independent of caspase-1 catalytic activity, defining a mode of action for caspase-1. Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders.

Lottery Action, September 9-22, 2002 Vol. 9, no. 17

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, November 4-17, 2002, Vol. 9, no. 21

Newsletter for Iowa Lottery

Lottery Action, August 25-September 7, 2003, Vol. 10, no. 17

Iowa Lottery Authority Retailer Information Newsletter

17-1-20, Congrès de Versailles : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57675

17-1-20, Congrès de Versailles, MM. Doumer [Paul] et Raux [Fernand] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57688

17-1-20, Congrès de Versailles, Mandel [Georges, député de la Gironde] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57683

17-1-20, Congrès de Versailles (salle des séances) : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57680

17-1-20, Congrès [de Versailles] arrivée de M. Deschanel [Paul] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57690