Military history of Ulysses S. Grant : from April, 1861, to April, 1865 /

Mode of access: Internet.

The sot-weed factor, or, A voyage to Maryland : a satyr : in which is describ'd, the laws, government, courts and constitutions of the country, and also the buildings, feasts, frolicks, entertainments and drunken humours of the inhabitants of that part of America ; in burlesque verse /

150 copies printed of which 36 were on large paper (29 x 23 cm.). Cf. Sabin, Bibl. Amer.

Les lois d'assurance ouvrière à l'étranger /

v. 1. Assurance contre la maladie.--v. 2. Assurance contre les accidents.--v. 3. Assurance contre l'invalidité.

Anti-slavery before Garrison; an address at a meeting of the Connecticut society of the Order of the founders and patriots of America, September 19, A. D. 1902,

Mode of access: Internet.

A catalogue of the library of Oriel College in the year 1375 A.D.

At head of title: "Part II." Date lettered on spine: 1865. Detached from Collectanea, Oxford University publication?

Cours d'analyse de l'École polytechnique /

1. t. Calcul différentiel: Variables réelles. Variables complexes. Séries. Applications géométriques de la série de Taylor. Courbes planes algébriques.--2. t. Calcul intégral: Intégrales ind��finies. Intégrales d��finies. Des fonctions représentées par des intégrales d��finies. Potentiels newtoniens. Séries de Fourier. Intégrales complexes. Fonctions elliptiques. Intégrales abéliennes.--3. t. Équations différentielles ordinaires. Équations linéaires. Équations aux d��rivées partielles. Calcul des variations. Potentiels newtoniens.

D��partement de l'Orne. Recueil des documents d'ordre économique contenus dans les registres de d��libérations des municipalités du district d'Alençon, 1788-an IV,

"M. Camille Bloch ... a suivi l'impression de cette publication en qualité de commissaire responsable."

Departement du Loiret. Cahiers de doleances du bailliage d'Orleans pour les Etats generaux de 1789, pub. par Camille Bloch.

Mode of access: Internet.

Cartulaires des abbayes d'Aniane et de Gellone publiés d'après les manuscrits originaux.

"Table chronologique et table alphabétique des matièrcs" and "Table des noms de personnes et des noms de lieux" of each vol. published in Montpellier by Imprimerie générale du Midi.

Karl XII:s död : en utredning /

Includes bibliographical references.

The whole works of the Right Rev. Jeremy Taylor /

v.1. The life of Taylor. Funeral sermon / by Bishop Rust. Correspondence with Mr. Henry Jeanes. Christian consolations. Indexes -- v.2. The history of the life and death of the Holy Jesus -- v.3. The history of the life and death of the Holy Jesus (cont.) Contemplations of the state of man -- v.4. The rule and exercises of holy living and dying -- v.5-6. Sermons -- v.7. Episcopacy asserted. An apology for authorized and set forms of liturgy. A discourse on the liberty of prophesying -- v.8. A discourse on the liberty of prophesying (cont.) The doctrine and practice of repentance -- v.9. The doctrine and practice of repentance (cont.) Deus justificatus. The real presence of Christ in the holy sacrament -- v.10. The real presence of Christ in the holy sacrament (cont.) A dissuassive from popery -- v.11. A dissuasive from popery (cont.) Letters. A discourse of confimation. A discourse of friendship. Ductor dubitantium; or, The rule of conscience -- v.12-13. The rule of conscience (cont.) -- v.14. The conclusion of the rule of conscience. The divine institution and necessity of the office ministerial. Rules and advices to the clergy -- v.15. The golden grove. The psalter. A collection of offices, or forms of prayer. Devotions for various occasions. The worthy communicant.

A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug

Relatively few cyclic peptides have reached the pharmaceutical marketplace during the past decade, most produced through fermentation rather than made synthetically. Generally, this class of compounds is synthesized for research purposes on milligram scales by solid-phase methods, but if the potential of macrocyclic peptidomimetics is to be realized, low-cost larger scale solution-phase syntheses need to be devised and optimized to provide sufficient quantities for preclinical, clinical, and commercial uses. Here, we describe a cheap, medium-scale, solution-phase synthesis of the first reported highly potent, selective, and orally active antagonist of the human C5a receptor. This compound, Ac-Phe[Orn-Pro-D-Cha-Trp-Arg], known as 3D53, is a macrocyclic peptidomimetic of the human plasma protein C5a and displays excellent antiinflammatory activity in numerous animal models of human disease. In a convergent approach, two tripeptide fragments Ac-Phe-Orn-(Boc)-Pro-OH and H-D-Cha-Trp(For)-Arg-OEt were first prepared by high-yielding solution-phase couplings using a mixed anhydride method before coupling them to give a linear hexapeptide which, after deprotection, was obtained in 38% overall yield from the commercially available amino acids. Cyclization in solution using BOP reagent gave the antagonist in 33% yield (13% overall) after HPLC purification. Significant features of the synthesis were that the Arg side chain was left unprotected throughout, the component Boe-D-Cha-OH was obtained very efficiently via hydrogenation Of D-Phe with PtO2 in TFA/water, the tripeptides were coupled at the Pro-Cha junction to minimize racemization via the oxazolone pathway, and the entire synthesis was carried out without purification of any intermediates. The target cyclic product was purified (>97%) by reversed-phase HPLC. This convergent synthesis with minimal use of protecting groups allowed batches of 50100 g to be prepared efficiently in high yield using standard laboratory equipment. This type of procedure should be useful for making even larger quantities of this and other macrocyclic peptidomimetic drugs.

Stirring in 3-d spherical models of convection in the Earth's mantle

On a global scale basalts from mid-ocean ridges are strikingly more homogeneous than basalts from intraplate volcanism. The observed geochemical heterogeneity argues strongly for the existence of distinct reservoirs in the Earth's mantle. It is an unresolved problem of Geodynamics as to how these findings can be reconciled with large-scale convection. We review observational constraints, and investigate stirring properties of numerical models of mantle convection. Conditions in the early Earth may have supported layered convection with rapid stirring in the upper layers. Material that has been altered near the surface is transported downwards by small-scale convection. Thereby a layer of homogeneous depleted material develops above pristine mantle. As the mantle cools over Earth history, the effects leading to layering become reduced and models show the large-scale convection favoured for the Earth today. Laterally averaged, the upper mantle below the lithosphere is least affected by material that has experienced near-surface differentiation. The geochemical signature obtained during the previous episode of small-scale convection may be preserved there for the longest time. Additionally, stirring is less effective in the high viscosity layer of the central lower mantle [1, 2], supporting the survival of medium-scale heterogeneities there. These models are the first, using 3-d spherical geometry and mostly Earth-like parameters, to address the suggested change of convective style. Although the models are still far from reproducing our planet, we find that proposal might be helpful towards reconciling geochemical and geophysical constraints.