CYP-450 isoenzymes catalyze the generation of hazardous aromatic amines after reaction with the azo dye Sudan III

This work describes the mutagenic response of Sudan III, an adulterant food dye, using Salmonella typhimurium assay and the generation of hazardous aromatic amines after different oxidation methods of this azo dye. For that, we used metabolic activation by S9, catalytic oxidation by ironporphyrin and electrochemistry oxidation in order to simulate endogenous oxidation conditions. The oxidation reactions promoted discoloration from 65% to 95% of Sudan III at 1×10-4molL-1 and generation of 7.6×10-7molL-1 to 0.31×10-4molL-1 of aniline, o-anisidine, 2-methoxi-5-methylaniline, 4-aminobiphenyl, 4,4'-oxydianiline; 4,4'-diaminodiphenylmethane and 2,6-dimethylaniline. The results were confirmed by LC-MS-MS experiments. We also correlate the mutagenic effects of Sudan III using S. typhimurium with the strain TA1535 in the presence of exogenous metabolic activation (S9) with the metabolization products of this compound. Our findings clearly indicate that aromatic amines are formed due to oxidative reactions that can be promoted by hepatic cells, after the ingestion of Sudan III. Considering that, the use of azo compounds as food dyestuffs should be carefully controlled. © 2013 Elsevier Ltd.

Division of labor in stable social hierarchy of the independent-founding wasp Mischocyttarus (Monocyttarus) cassununga, von Ihering (Hymenoptera, Vespidae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Liquid foam templates associated with the sol-gel process for production of zirconia ceramic foams

The unique properties of ceramic foams enable their use in a variety of applications. This work investigated the effects of different parameters on the production of zirconia ceramic foam using the sol-gel process associated with liquid foam templates. Evaluation was made of the influence of the thermal treatment temperature on the porous and crystalline characteristics of foams manufactured using different amounts of sodium dodecylsulfate (SDS) surfactant. A maximum pore volume, with high porosity (94%) and a bimodal pore size distribution, was observed for the ceramic foam produced with 10% SDS. Macropores, with an average size of around 30 μm, were obtained irrespective of the SDS amount, while the average size of the supermesopores increased systematically as the SDS amount was increased up to 10%, after which it decreased. X-ray diffraction analyses showed that the sample treated at 500 °C was amorphous, while crystallization into a tetragonal metastable phase occurred at 600 °C due to the presence of sulfate groups in the zirconia structure. At 800 and 1000 °C the monoclinic phase was observed, which is thermodynamically stable at these temperatures. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

Programa provisional de trabajo del Comité de Desarrollo y Cooperación del Caribe para el período 1984-1985 = Draft programme of work of the Caribbean Development and Co-operation Committee 1984-1985

Incluye Bibliografía

Proyecto de programa de trabajo del Comité de Desarrollo y Cooperación del Caribe 1988-1989 = Draft programme of work of the Caribbean Development and Co-operation Committee 1988-89 = Projet de programme de travail du CDCC pour 1988-89

Presenta el proyecto del Programa de Trabajo 1988-1989 del CDCC, en que las principales areas de actividad expresadas como elementos de programa son: a) estudio economico de paises del Caribe; b) agricultura y alimentacion; c) planificacion economica y social; d) ciencia y tecnologia; e) recursos naturales, gestion ambiental y desarrollo; f) informacion y documentacion para el desarrollo economico y social; g) apoyo de la CEPAL a los paises del Caribe Oriental; h) banco de datos estadisticos; i) comercio y finanzas internacionales; j) transporte y comunicaciones; y k) poblacion.

Social security in the English-speaking Caribbean

Includes bibliography

The concrete utopias and their confrontation with the world of today

Includes bibliography

Infrastructure, integration and equity: The social impact of the health and public transportation infrastructure.

Academicians and practitioners generally agree that there is a positive correlation between more and better infrastructure and economic growth. From the broader perspective of development, attempts have been made in the literature to identify the different theoretical connections and the empirical patterns that link infrastructure to productivity, on the one hand, and those that link it to social inclusion and equity, on the other hand. Infrastructure contributes to development in different ways. The capital involved is not homogeneous, nor is its effect on the distributive aspects. Water and sanitation have a particularly strong association with the health of the general population and with infant mortality, early childhood health, learning abilities and the acquisition of labour skills. With respect to transportation, the reduction of costs and travel times has a direct economic impact on economic activities of production and domestic and international distribution. That infrastructure also has a social and distributive role to play by reducing the number of fatal accidents and serious injuries in the sectors that are naturally most susceptible to them, namely, the poor. Under the broad umbrella of infrastructure, we can include a number of facilities that make possible the provision of certain services. Some of these facilities require very significant fixed capital investments; some of them are residential, while others are not necessarily. What they all have in common is the existence of networks (transportation, wiring, pipelines) and a strong convergence of physical capital and/or technology, as well as the need for major investments in periodic maintenance.

Produção do conhecimento em Serviço Social: análise das dissertações de mestrado defendidas no Programa de Pós-graduação em Serviço Social da Unesp - Campus Franca entre 1999 e 2009 e a interface com a indústria calçadista de Franca-SP

Pós-graduação em Serviço Social - FCHS

O Serviço Social no INSS: uma trajetória de contribuição na efetivação dos direitos sociais

Pós-graduação em Serviço Social - FCHS

O Conselho Municipal de Assistência Social de São José do Rio Preto-SP: sua inserção na política de assistência social no município

Pós-graduação em Serviço Social - FCHS

A dimensão educativa na prática profissional do assistente social no trabalho com comunidades em Campinas-SP 2001-2004

Pós-graduação em Serviço Social - FCHS

O profissional de serviço social na educação infantil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)