Die Frauenburg oder der Sturz vom Felsen : Nach einer Sage bearbeitet und als Probe theatralischen Versuches herausgegeben

von Laura Kraus, geborne von B.

[Fraktur-Probe]

Georg. Gottl. Burchard

[Fraktur-Probe]

[Zufinden bey Johann Georg Bauman Schriftschneider und Schriftgießer in Nürnberg]

[Fraktur-Probe] Obgesetzter Schrifften Prob und Abguß, findet man umb die Gebühr zu giessen, theils auch zu verkauffen

bey mir Anthoni Janson, Schrifftgießer in Leipzig ...

[Antiqua- und Fraktur-Probe]

[Pankraz Lobinger]

Pilzige Fische und deren Behandlung (nach eigener Probe)

Von Chr. Felsberg

Herbert Hesse, John Gläser, Hans Meissner, Emmy Hainmüller, Clemens Kraus {[u.a.] nach der General-Probe zu Meistersinger, Frankfurt a. M.

Signatur des Originals: S 36/F04513

Hans Pfitzner, Bruno Walter, Karl Erb, Fritz Feinhals, Emmy Krüger, Friedrich Brodersen, {[N.N.], Gruppenbildnis, Anlass des Treffens: Probe zu Palestrina, München, 1917

Signatur des Originals: S 36/F05747

Hans Pfitzner, Bruno Walter, Karl Erb, Fritz Feinhals, Emmy Krüger, Friedrich Brodersen, {[N.N.], Gruppenbildnis, Anlass des Treffens: Probe zu Palestrina, München, 1917

Signatur des Originals: S 36/F05748

Philharmonischer Chor in Berlin (Dirigent: Prof. Siegfried Ochs). Probe in der Philharmonie

Signatur des Originals: S 36/F07792

Ausstellung "Das Theater im Freien", Frankfurt a. M. - Die Stadt des deutschen Handwerks in Verbindung mit dem Reichsbund der deutschen Freilicht- und Volksschauspiele E. V. : Die Probe im Park - Deutsches Ölgemälde aus der 2. Hälfte des 18. Jahrhunderts. Sammlung Niessen.

Signatur des Originals: S 36/F07992

Rudolf Brinkmann, Hermann Schramm, Erik Wirl, Enrico Caruso, Walter Schneider {[u.a.], Gruppenbildnis, nach der Probe von Ruggero Leoncavallo: I Pagliacci mit Enrico Caruso, 1909

Signatur des Originals: S 36/F07814

Systems Biology Approaches to Probe Gene Regulation in Bacteria

Mechanisms that allow pathogens to colonize the host are not the product of isolated genes, but instead emerge from the concerted operation of regulatory networks. Therefore, identifying components and the systemic behavior of networks is necessary to a better understanding of gene regulation and pathogenesis. To this end, I have developed systems biology approaches to study transcriptional and post-transcriptional gene regulation in bacteria, with an emphasis in the human pathogen Mycobacterium tuberculosis (Mtb). First, I developed a network response method to identify parts of the Mtb global transcriptional regulatory network utilized by the pathogen to counteract phagosomal stresses and survive within resting macrophages. As a result, the method unveiled transcriptional regulators and associated regulons utilized by Mtb to establish a successful infection of macrophages throughout the first 14 days of infection. Additionally, this network-based analysis identified the production of Fe-S proteins coupled to lipid metabolism through the alkane hydroxylase complex as a possible strategy employed by Mtb to survive in the host. Second, I developed a network inference method to infer the small non-coding RNA (sRNA) regulatory network in Mtb. The method identifies sRNA-mRNA interactions by integrating a priori knowledge of possible binding sites with structure-driven identification of binding sites. The reconstructed network was useful to predict functional roles for the multitude of sRNAs recently discovered in the pathogen, being that several sRNAs were postulated to be involved in virulence-related processes. Finally, I applied a combined experimental and computational approach to study post-transcriptional repression mediated by small non-coding RNAs in bacteria. Specifically, a probabilistic ranking methodology termed rank-conciliation was developed to infer sRNA-mRNA interactions based on multiple types of data. The method was shown to improve target prediction in Escherichia coli, and therefore is useful to prioritize candidate targets for experimental validation.

(Table 1) Physical properties of sediments at DSDP Holes 69-504 and 69-505

Values of physical properties measured in the upper sections of sediment cores recovered at Sites 504 and 505 exhibit a remarkable similarity. Below a depth of 145 m Site 504 sediments appear to have undergone changes which are reflected in physical property values. This alteration may have been due to high temperatures in the sediment. In most of Site 505, and in Site 504 above 145 m, seismic velocity averages 1.51 km/s, wet bulk density 1.32 g/cm**3, porosity 80%, and thermal conductivity 0.80% W/m °K. Below 145 m at Site 504 and 210 m at Site 505, mean density increases to 1.40 g/cm**3, porosity decreases to 67%, seismic velocity increases to 1.53 km/s, and thermal conductivity increases to values in excess of 1.0 W/m °K. A good correlation between independent measurements of water content and thermal resistivity supports the existence of small but regular variation in the measured parameters on the scale of 10 m and less.