Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development.

Several human neurological disorders are associated with proteins containing abnormally long runs of glutamine residues. Strikingly, most of these proteins contain two or more additional long runs of amino acids other than glutamine. We screened the current human, mouse, Drosophila, yeast, and Escherichia coli protein sequence data bases and identified all proteins containing multiple long homopeptides. This search found multiple long homopeptides in about 12% of Drosophila proteins but in only about 1.7% of human, mouse, and yeast proteins and none among E. coli proteins. Most of these sequences show other unusual sequence features, including multiple charge clusters and excessive counts of homopeptides of length > or = two amino acid residues. Intriguingly, a large majority of the identified Drosophila proteins are essential developmental proteins and, in particular, most play a role in central nervous system development. Almost half of the human and mouse proteins identified are homeotic homologs. The role of long homopeptides in fine-tuning protein conformation for multiple functional activities is discussed. The relative contributions of strand slippage and of dynamic mutation are also addressed. Several new experiments are proposed.

Towards a New (European Research) Deal: The Case for Enhanced Fiscal Policy Coordination on Research and Innovation. Bruges European Economic Policy (BEEP) Briefing 20/2008

The paper reviews the evolution of research and innovation in the EU and assesses how current policies and programmes have influenced the development of Europe's research landscape. Based on existing literature, evaluation reports and practice, the paper critically examines the effectiveness of current European research funding instruments in a context of open innovation and in the presence of global spillovers. It therefore develops a subsidiarity test to assess whether current rationales still prove sufficient to justify policy intervention in this area. The paper sheds light on how to improve the effectiveness of EU action by enriching it by the use of coordinated fiscal policy for research funding. This will constitute an incentive to genuine bottom-up research, development and innovation (R&D&I) and a stimulus to local investments in innovation. The paper also assesses the potentials of a reinforced open method of coordination as well as a review of state aid law in the field of research funding in the EU.

Real options in the context of innovation and development policies and practices. ACES Working Papers, 2012

This paper proposes to build on previous research on the use of real options in strategic decision making (Carayannis and Sipp, 2010) and instill some real options-related concepts stemming from systems design, more particularly engineering. It also builds on previously-established concepts of strategic knowledge serendipity and arbitrage and strategic knowledge co-opetition, co-evolution and co-specialization developed by Carayannis (2009). The application of real options “in” system and real options to innovation and innovation policies demonstrate how embedded real options can more effectively be identified and therefore the decision to execute them or not more effectively made.

Minorities and women as government contractors : a report of the United States Commission on Civil Rights.

Cover title.

Development of proposed height standards and tolerances for light-post traffic barriers. Interim report.

Federal Highway Administration, Office of Research, Development and Technology, Washington, D.C.

University funding: federal funding mechanisms in support of university research.

Mode of access: Internet.

Development and testing of INTRAS, a microscopic freeway simulation model. Volume 4: program documentation. Final report.

Federal Highway Administration, Office of Research and Development, Washington, D.C.

Improving environmental quality through the use of local ordinances and regulations /

Cover tite: The use of existing and modified land use instruments to achieve environmental quality.

Groundwater quality monitoring of Western oil shale development : identification and priority ranking of potential pollution sources /

Mode of access: Internet.

Data storage and retrieval system for pilot watewater treatment research /

Mode of access: Internet.

Development of methods and techniques for final treatment of combined municipal and textile wastewater, including sludge utilization and disposal /

Issued Dec. 1979.

Self-regulation of environmental quality : impact analysis in California local government /

Mode of access: Internet.

Effects of mirex, methoxychlor, and malathion on development of crabs /

Mode of access: Internet.

Development of treatment and control technology for refractory petrochemical wastes /

Mode of access: Internet.

Analysis of federal stimuli to development of new technology by suppliers to automobile manufacturers. An exploratory study of barriers and facilitators. Final report.

National Highway Traffic Safety Administration, Office of Research and Development, Washington, D.C.