935 resultados para Reference transcriptome


Relevância:

20.00% 20.00%

Publicador:

Resumo:

Describe la organización, metas y objetivos del proceso de planificación para el desarrollo de la agricultura en Barbados.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Vampire bats are notorious for being the sole mammals that strictly feed on fresh blood for their survival. While their saliva has been historically associated with anticoagulants, only one antihemostatic (plasminogen activator) has been molecularly and functionally characterized. Here, RNAs from both principal and accessory submaxillary (submandibular) salivary glands of Desmodus rotundus were extracted, and ~. 200. million reads were sequenced by Illumina. The principal gland was enriched with plasminogen activators with fibrinolytic properties, members of lipocalin and secretoglobin families, which bind prohemostatic prostaglandins, and endonucleases, which cleave neutrophil-derived procoagulant NETs. Anticoagulant (tissue factor pathway inhibitor, TFPI), vasodilators (PACAP and C-natriuretic peptide), and metalloproteases (ADAMTS-1) were also abundantly expressed. Members of the TSG-6 (anti-inflammatory), antigen 5/CRISP, and CCL28-like (antimicrobial) protein families were also sequenced. Apyrases (which remove platelet agonist ADP), phosphatases (which degrade procoagulant polyphosphates), and sphingomyelinase were found at lower transcriptional levels. Accessory glands were enriched with antimicrobials (lysozyme, defensin, lactotransferrin) and protease inhibitors (TIL-domain, cystatin, Kazal). Mucins, heme-oxygenase, and IgG chains were present in both glands. Proteome analysis by nano LC-MS/MS confirmed that several transcripts are expressed in the glands. The database presented herein is accessible online at http://exon.niaid.nih.gov/transcriptome/D_rotundus/Supplemental-web.xlsx. These results reveal that bat saliva emerges as a novel source of modulators of vascular biology. Biological significance: Vampire bat saliva emerges as a novel source of antihemostatics which modulate several aspects of vascular biology. © 2013.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Presenta las atribuciones y reglamentos de la Comisión en cuanto a las reuniones, la Secretaría, las votaciones, los idiomas, los informes, etc.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Somete a consideracion de las delegaciones las enmiendas propuestas al texto de las atribuciones de CEPAL, documento E/CN.12/850/Rev.1.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Objectives: To evaluate the surgical outcomes of patients with complete unilateral cleft lip and palate (CUCLP) operated on by a single surgeon of the cleft reference center of the Lauro Wanderley University Hospital at the Federal University of Paraiba. Methods: Forty-four individuals' dental casts diagnosed with CUCLP, born between 1995 and 2002, mean age of 11 years, were evaluated by three calibrated orthodontic specialists and scored by the Great Ormond Street, London and Oslo (GOSLON) yardstick on two occasions. The scores were compared with those observed in other centers around the world. The Kappa test was applied to evaluate the intra- and inter-examiner agreement. Descriptive statistics was applied for the GOSLON yardsticks core. Results: The mean GOSLON score was 2.75. For the GOSLON yardstick, 43.2 % of the sample presented scores 1 and 2, 31.8 % had score 3, and 25 % were with scores 4 and 5. There was very good intra- and inter-examiner Kappa agreement in the application of the GOSLON yardstick. Conclusions: The data suggest favorable outcomes, with 75 % of cases with no need of orthognathic surgery. The Kappa values confirmed the high reproducibility of the GOSLON yardstick. © 2013 Springer-Verlag Berlin Heidelberg.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Based on the framework of the Conservative Power Theory (CPT), this paper proposes some compensation strategies for shunt current compensators. CPT current decompositions result in several current-related terms associated with specific load characteristics, such as power consumption, energy storage, unbalances and load nonlinearities. These current components are decoupled (orthogonal) from each other and are used here to define different compensation strategies, which can be selective in minimizing particular effects of disturbing loads. Compensation strategies for single- and three-phase four-wire circuits are also considered. Simulated and experimental results are described to validate the possibilities and performance of the proposed strategies. © 2013 Brazilian Society for Automatics - SBA.