Diseño y desarrollo de un videojuego sobre plataforma móvil

Vivimos rodeados de tecnología. La irrupción de ordenadores, tablets y smartphones en la sociedad ha hecho que ésta cambie y ha conseguido que sean posibles nuevos métodos de enseñanza mediante el empleo de estos dispo sitivos. Entre los nuevos métodos de enseñanza aparece el uso de los videojuegos como medio de aprendizaje. Son videojuegos, que a diferencia de los videojuegos tradicionales, no buscan el entretenimiento del jugador sino formarle dejando la diversión en un segundo plano. Estos juegos no están destinados exclusivamente al campo de la educación. Instituciones como el ejército también hacen uso de ellos para preparar a sus tropas, e incluso los hospitales los utilizan como métodos de rehabilitación. El desarrollo de videojuegos puede realizarse con un mínimo de conocimiento en programación tanto a nivel individual o como en grupos reducidos. Esto es posible gracias a las facilidades que ofrecen los motores gráficos de hoy en día. Con este proyecto se quiso realizar un tutorial que facilite el diseño y desarrollo de videojuegos sobre una plataforma móvil, como es Android , de cara a su uso posterior en la creación de juegos serios. Para el desarrollo del tutorial se elaboró un videojuego de plataformas en avance 2D. ABSTRACT: We are surounded by technologies. As computers, tablets and smartphones have arisen, our society has chaned, making use of these new technological devices in teaching area. Videogames use arises as a new way of learning, so it complements the traditional methods of teaching. The main aim of serious videogames, in contrast to videogames which people usually buy in any store, is training instead of entertaining. Recreation is on a secondary plane. Serious games aren’t only designed for education but also for other institutions such as the army (to train the troops) and hospitals (as a rehabilitation method). Videogames development can be done by an individual on group of people if they have a bascis knowledge of programming. This is posible due to graphic motors have a lot of aids in the present. This project tries to make a tutorial that makes the design and development of serious games easier. A platform videogame in advance 2D has been made for the development of this tutorial.

Do direito do mar e de seus avatares : a plataforma continental brasileira

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Multifaceted Physiological Response Allows Yeast to Adapt to the Loss of the Signal Recognition Particle-dependent Protein-targeting PathwayD⃞

Translational control has recently been recognized as an important facet of adaptive responses to various stress conditions. We describe the adaptation response of the yeast Saccharomyces cerevisiae to the loss of one of two mechanisms to target proteins to the secretory pathway. Using inducible mutants that block the signal recognition particle (SRP) pathway, we find that cells demonstrate a physiological response to the loss of the SRP pathway that includes specific changes in global gene expression. Upon inducing the loss of the SRP pathway, SRP-dependent protein translocation is initially blocked, and cell growth is considerably slowed. Concomitantly, gene expression changes include the induction of heat shock genes and the repression of protein synthesis genes. Remarkably, within hours, the efficiency of protein sorting improves while cell growth remains slow in agreement with the persistent repression of protein synthesis genes. Our results suggest that heat shock gene induction serves to protect cells from mislocalized precursor proteins in the cytosol, whereas reduced protein synthesis helps to regain efficiency in protein sorting by reducing the load on the protein translocation apparatus. Thus, we suggest that cells trade speed in cell growth for fidelity in protein sorting to adjust to life without SRP.

Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.

Antibody-directed enzyme prodrug therapy, ADEPT, is a recent approach to targeted cancer chemotherapy intended to diminish the nonspecific toxicity associated with many commonly used chemotherapeutic agents. Most ADEPT systems incorporate a bacterial enzyme, and thus their potential is reduced because of the immunogenicity of that component of the conjugate. This limitation can be circumvented by the use of a catalytic antibody, which can be "humanized," in place of the bacterial enzyme catalyst. We have explored the scope of such antibody-directed "abzyme" prodrug therapy, ADAPT, to evaluate the potential for a repeatable targeted cancer chemotherapy. We report the production of a catalytic antibody that can hydrolyze the carbamate prodrug 4-[N,N-bis(2-chloroethyl)]aminophenyl-N-[(1S)-(1,3- dicarboxy)propyl]carbamate (1) to generate the corresponding cytotoxic nitrogen mustard (Km = 201 microM, kcat = 1.88 min-1). In vitro studies with this abzyme, EA11-D7, and prodrug 1 lead to a marked reduction in viability of cultured human colonic carcinoma (LoVo) cells relative to appropriate controls. In addition, we have found a good correlation between antibody catalysis as determined by this cytotoxicity assay in vitro and competitive binding studies of candidate abzymes to the truncated transition-state analogue ethyl 4-nitrophenylmethylphosphonate. This cell-kill assay heralds a general approach to direct and rapid screening of antibody libraries for catalysts.