Les zones industrielles d’exportation : Le cas de la Tunisie

Ce mémoire compte deux parties distinctes, chacune étant toutefois rattachée à une étude du régime des entreprises entièrement exportatrices de la Tunisie, à laquelle nous avons participé. Ce régime instauré en 1972, avec des modifications depuis, avait pour but d'établir des conditions favorables à la venue d'investissements étrangers dans les secteurs d'exportation. Ce type de régime correspond, dans ses grandes lignes, à ce qu'il est convenu d'appeler les zones industrielles d'exportation. La première partie de ce mémoire est une revue de la littérature sur le sujet, une étude du pour et du contre autant d'un point de vue théorique que pratique. Nous tenterons par la suite d'en dégager des points de réflexion sur l'expérience tunisienne. Celle-ci a-t-elle rencontré des conditions qui favorisait sa réussite? Toujours dans le cadre de l'étude du régime tunisien, il a été nécessaire d'utiliser le concept de "taux de change de référence"(TCR), afin d'évaluer les avantages et les coûts de l'établissement de tels incitatifs. Il s'agit en quelque sorte de calculer le prix de référence (shadow price) des devises utilisées dans ce régime ou générées par lui. La seconde partie de ce mémoire consiste, dans un premier temps, à expliquer les bases théoriques du taux de change de référence, c'est-à-dire à en établir la définition selon deux différentes approches, et à en donner les formes d'évaluation. Dans un deuxième temps, nous tentons d'estimer le TCR de la Tunisie. Cet exercice avait déjà été tenté par l'Institut d'Économie Quantitative de la Tunisie en 1988 sur la base de la protection commerciale existante en 1983. Cependant, la fiabilité du résultat pouvait être améliorée en ce qui concerne l'estimation de l'élasticité des demandes d'importation. Nous avons refait ces estimations en utilisant un plus grand nombre de données. De plus nous avons basé nos calculs du TCR sur la base de la protection existante en 1990.

Effects of Soil Organic Matter Properties and Microbial Community Composition on Enzyme Activities in Cryoturbated Arctic Soils

Enzyme-mediated decomposition of soil organic matter (SOM) is controlled, amongst other factors, by organic matter properties and by the microbial decomposer community present. Since microbial community composition and SOM properties are often interrelated and both change with soil depth, the drivers of enzymatic decomposition are hard to dissect. We investigated soils from three regions in the Siberian Arctic, where carbon rich topsoil material has been incorporated into the subsoil (cryoturbation). We took advantage of this subduction to test if SOM properties shape microbial community composition, and to identify controls of both on enzyme activities. We found that microbial community composition (estimated by phospholipid fatty acid analysis), was similar in cryoturbated material and in surrounding subsoil, although carbon and nitrogen contents were similar in cryoturbated material and topsoils. This suggests that the microbial community in cryoturbated material was not well adapted to SOM properties. We also measured three potential enzyme activities (cellobiohydrolase, leucine-amino-peptidase and phenoloxidase) and used structural equation models (SEMs) to identify direct and indirect drivers of the three enzyme activities. The models included microbial community composition, carbon and nitrogen contents, clay content, water content, and pH. Models for regular horizons, excluding cryoturbated material, showed that all enzyme activities were mainly controlled by carbon or nitrogen. Microbial community composition had no effect. In contrast, models for cryoturbated material showed that enzyme activities were also related to microbial community composition. The additional control of microbial community composition could have restrained enzyme activities and furthermore decomposition in general. The functional decoupling of SOM properties and microbial community composition might thus be one of the reasons for low decomposition rates and the persistence of 400 Gt carbon stored in cryoturbated material.

Dévaluation et commerce international : une étude sur quelques pays de la zone CFA

Le travail examine le rôle des prix dans le processus d’ajustement de la balance commerciale des pays de la zone CFA et vérifie la pertinence de la condition Marshall Lerner. Nous avons dérivé des fonctions d'importation et d'exportation à partir d'un problème d'optimisation dynamique puisé dans l'article de Reinhart (1994). Nous nous sommes servis des tests de cointégration. L'étude est calibrée sur le Cameroun, la Côte d'Ivoire, le Gabon et le Togo. Les résultats laissent croire qu'il n'existe pas de relation de long terme entre les prix, les exportations et les importations. La condition Marshall Lerner s'est révélée non valable à court terme. La révision des hypothèses sous-jacentes à cette condition a mis en exergue les élasticités des importations dans les possibilités de réussite de cette dévaluation.

Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 through Stimulation of E2-Ubiquitin Thioester Hydrolysis.

Mouse double minute 2 (MDM2) has a phosphorylation site within a lid motif at Ser17 whose phosphomimetic mutation to Asp17 stimulates MDM2-mediated polyubiquitination of p53. MDM2 lid deletion, but not Asp17 mutation, induced a blue shift in the λmax of intrinsic fluorescence derived from residues in the central domain including Trp235, Trp303, Trp323, and Trp329. This indicates that the Asp17 mutation does not alter the conformation of MDM2 surrounding the tryptophan residues. In addition, Phe235 mutation enhanced MDM2 binding to p53 but did not stimulate its ubiquitination function, thus uncoupling increases in p53 binding from its E3 ubiquitin ligase function. However, the Asp17mutation inMDM2 stimulated its discharge of the UBCH5a-ubiquitin thioester adduct (UBCH5a is a ubiquitin-conjugating enzyme E2D 1 UBC4/5 homolog yeast). This stimulation of ubiquitin discharge fromE2 was independent of the p53 substrate. There are now four known effects of the Asp17 mutation on MDM2: (i) it alters the conformation of the isolated N-terminus as defined by NMR; (ii) it induces increased thermostability of the isolated N-terminal domain; (iii) it stimulates the allosteric interaction ofMDM2 with the DNA-binding domain of p53; and (iv) it stimulates a novel protein–protein interaction with the E2-ubiquitin complex in the absence of substrate p53 that, in turn, increases hydrolysis of theE2-ubiquitin thioester bond. These data also suggest a new strategy to disrupt MDM2 function by targeting the E2-ubiquitin discharge reaction.

Plant-derived compounds stimulate the decomposition of organic matter in arctic permafrost soils

Arctic ecosystems are warming rapidly, which is expected to promote soil organic matter (SOM) decomposition. In addition to the direct warming effect, decomposition can also be indirectly stimulated via increased plant productivity and plant-soil C allocation, and this so called "priming effect" might significantly alter the ecosystem C balance. In this study, we provide first mechanistic insights into the susceptibility of SOM decomposition in arctic permafrost soils to priming. By comparing 119 soils from four locations across the Siberian Arctic that cover all horizons of active layer and upper permafrost, we found that an increased availability of plant-derived organic C particularly stimulated decomposition in subsoil horizons where most of the arctic soil carbon is located. Considering the 1,035 Pg of arctic soil carbon, such an additional stimulation of decomposition beyond the direct temperature effect can accelerate net ecosystem C losses, and amplify the positive feedback to global warming.

Photoluminescent materials based on PMMA and a highly-emissive octahedral molybdenum metal cluster complex

Materials that combine photoluminescence, optical transparency and facile processability are of high importance in many applications. This article reports on the development of photoluminescent poly(methyl methacrylate) materials based on novel highly emissive anionic molybdenum cluster complex [{Mo6I8}(OTs)6]2- (where OTs- is the p-toluenesulfonate ion). The materials were obtained by both solution and bulk copolymerisation of methyl methacrylate and (dMDAEMA)2[{Mo6I8}(OTs)6], where dMDAEMA+ is the polymerisable cation [2-(methacryloyloxy)ethyl]dimethyl-dodecylammonium. Evaluation of the resultant hybrid materials showed that one could combine the excellent photoluminescent properties of the cluster complex with the transparency and processability of PMMA.

Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein

Despite existing knowledge about the role of the A Disintegrin and Metalloproteinase 10 (ADAM10) as the α-secretase involved in the non-amyloidogenic processing of the amyloid precursor protein (APP) and Notch signalling we have only limited information about its regulation. In this study, we have identified ADAM10 interactors using a split ubiquitin yeast two hybrid approach. Tetraspanin 3 (Tspan3), which is highly expressed in the murine brain and elevated in brains of Alzheimer's disease (AD) patients, was identified and confirmed to bind ADAM10 by co-immunoprecipitation experiments in mammalian cells in complex with APP and the γ-secretase protease presenilin. Tspan3 expression increased the cell surface levels of its interacting partners and was mainly localized in early and late endosomes. In contrast to the previously described ADAM10-binding tetraspanins, Tspan3 did not affect the endoplasmic reticulum to plasma membrane transport of ADAM10. Heterologous Tspan3 expression significantly increased the appearance of carboxy-terminal cleavage products of ADAM10 and APP, whereas N-cadherin ectodomain shedding appeared unaffected. Inhibiting the endocytosis of Tspan3 by mutating a critical cytoplasmic tyrosine-based internalization motif led to increased surface expression of APP and ADAM10. After its downregulation in neuroblastoma cells and in brains of Tspan3-deficient mice, ADAM10 and APP levels appeared unaltered possibly due to a compensatory increase in the expression of Tspans 5 and 7, respectively. In conclusion, our data suggest that Tspan3 acts in concert with other tetraspanins as a stabilizing factor of active ADAM10, APP and the γ-secretase complex at the plasma membrane and within the endocytic pathway.

¿Cambiar para seguir igual? la experiencia de la oposición política rusa: del legado de la Perestroika a la democracia soberana

El colapso de la Unión Soviética a inicios de los años noventa del siglo pasado, constituyó para Rusia un punto de partida para su reconfiguración y reestructuración como un país independiente. En este proceso de reconfiguración y reestructuración Rusia ha adoptado diferentes elementos de la cultura política occidental; situación que resulta de gran interés, toda vez que en los años de la Guerra Fría la Rusia comunista encarnaba la antítesis de Occidente a nivel ideológico, político y económico. Esta investigación pretende estudiar la oposición política en Rusia entre los años 2004 y 2012, y, con ello, presentar algunos elementos clave en la comprensión de las acciones, relaciones e influencia de los diferentes actores del nuevo sistema político de esta potencia mundial.

Analysis of Needs and Resources

The initial aim of the CareMan project was to develop a joint degree programme that combined and utilised the strengths of the five collaborating universities that were already involved in delivering social and health care management education. Because the project was to be implemented in collaboration between education- al institutions, the collaboration had to be based on a detailed understanding of the national and institutional specifics of each of the individual academic enti- ties. During this process it was recognised that, due to a number of regulation issues, achieving the original aim would not be possible; ultimately, following a series of analytical works, which are presented below, it was decided that a set of three master’s level modules should be developed. One of the reasons was that the Finnish law on master’s degrees at universities of applied sciences (UAS) stated that the requirement for entry to a UAS master’s programme was a bachelor degree from a UAS or equivalent, plus a minimum of three years of work experience in an appropriate field. The three years’ work experience is also required from international students. In practice this meant that the participating Finnish UASs, Lahti and HAMK, could not award a diploma for foreign students without this work experience. The other European universities do not have the work experience requirement, although some take it as a bonus for admission (FHS UK). There were also other differences in law (e.g., requirements for mini - mum standards in Social Work education at FHS UK) that could not have been overcome during the period of project realisation. Consequently, the outcome was the development of only three common educational modules, each for 10 ECTS, which were developed, delivered and assessed during the lifetime of the project. The intention was that these would be integrated into the current masters’ level provision in each of the universities