translin Is Required for Metabolic Regulation of Sleep

Dysregulation of sleep or feeding has enormous health consequences. In humans, acute sleep loss is associated with increased appetite and insulin insensitivity, while chronically sleep-deprived individuals are more likely to develop obesity, metabolic syndrome, type II diabetes, and cardiovascular disease. Conversely, metabolic state potently modulates sleep and circadian behavior; yet, the molecular basis for sleep-metabolism interactions remains poorly understood. Here, we describe the identification of translin (trsn), a highly conserved RNA/DNA binding protein, as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation. While broadly expressed in all neurons, trsn is transcriptionally upregulated in the heads of flies in response to starvation. Spatially restricted rescue or targeted knockdown localizes trsn function to neurons that produce the tachykinin family neuropeptide Leucokinin. Manipulation of neural activity in Leucokinin neurons revealed these neurons to be required for starvation-induced sleep suppression. Taken together, these findings establish trsn as an essential integrator of sleep and metabolic state, with implications for understanding the neural mechanism underlying sleep disruption in response to environmental perturbation.

An intercontinental comparison of chironomid palaeotemperature inference models: Europe vs North America

Chironomid-temperature inference models based on North American, European and combined surface sediment training sets were compared to assess the overall reliability of their predictions. Between 67 and 76 of the major chironomid taxa in each data set showed a unimodal response to July temperature, whereas between 5 and 22 of the common taxa showed a sigmoidal response. July temperature optima were highly correlated among the training sets, but the correlations for other taxon parameters such as tolerances and weighted averaging partial least squares (WA-PLS) and partial least squares (PLS) regression coefficients were much weaker. PLS, weighted averaging, WA-PLS, and the Modern Analogue Technique, all provided useful and reliable temperature inferences. Although jack-knifed error statistics suggested that two-component WA-PLS models had the highest predictive power, intercontinental tests suggested that other inference models performed better. The various models were able to provide good July temperature inferences, even where neither good nor close modern analogues for the fossil chironomid assemblages existed. When the models were applied to fossil Lateglacial assemblages from North America and Europe, the inferred rates and magnitude of July temperature changes varied among models. All models, however, revealed similar patterns of Lateglacial temperature change. Depending on the model used, the inferred Younger Dryas July temperature decrease ranged between 2.5 and 6°C.

The Right to Die Debate: The Demonization of Dr. Kevorkian and the Creation of a Moral Panic Surrounding Physician-Assisted Suicide in the United States

The Right to Die Debate is a recent but highly controversial moral matter. In particular, physician-assisted suicide (PAS) is an issue that has been evaded by the medical community for years. As of 1990, most states had never encountered the issue before and therefore did not have any laws in place to prohibit PAS (Strate et. al, 2005). Dr. Jack Kevorkian, a retired pathologist from Royal Oak Michigan was the first to publicly address PAS. He brought the issue into the limelight through a bizarre and crude series of assisted deaths that had a lasting impact on not only the Right to Die Debate as whole, but on public policy and both federal and state governmental agendas. This study focuses on the way in which the media, in particular the New York Times (NYT) has portrayed Dr. Jack Kevorkian as incompetent, morally culpable and in an overall negative light in the past twenty years. Applying Stanley Cohen’s 1972 theory of moral panic, a content analysis of NYT media publications between 1990 and 1999 supports Cohen’s theory and reveals that the media has created a moral panic surrounding Kevorkian. This has in turn led to public policy that prevents both terminally ill individuals and their doctors from having a desirable choice; that of voluntary euthanasia and PAS.

Volume 10, Number 3: September/October 2004

Page 2 - Users tell us what they think about library service, and library director Brinley Franklin explains why he thinks the library is a good investment. Page 3 - Pulitzer Prize-winning music critic Tim Page, once the beneficiary of the library’s music collections, is now a patron of the Music & Dramatic Arts Library. Page 4 - Donors to the Libraries during FY 2004 Page 5 - Remembering Theora Whetten, long-time Friend of the Libraries; welcoming new Friends, the Class of ‘55. Page 6 - Beach Society members include the Libraries in their estate plans. Stamford honors Estelle Feinstein. Page 7 - Jack & Virginia Stephens donate a collection of Connecticut town histories.

Lost Youth : successfully introduced by Jennie Goldstein in Max Gabel's comedy drama "Ferlorene Yugend" at Gabel's Theatre New York City

words and music by David Meyerowitz. [Arr. by Jack Kammen]

Hypnum (Limnobium) Gerwigii

Von J. B. Jack

Botanische Wanderungen am Bodensee und im Hegau

Von Jos. Bernh. Jack

Botanische Wanderungen am Bodensee und im Hegau

Von Jos. Bernh. Jack

Botanische Wanderungen am Bodensee und im Hegau

Von Jos. Bernh. Jack

Botanische Wanderungen am Bodensee und im Hegau

Von Jos. Bernh. Jack

Botanischer Ausflug in's obere Donauthal

Von Jos. Bernh. Jack

Anhang zu "Botanische Wanderungen am Bodensee und im Hegau"

Von Jos. Bernh. Jack

Flora von Achern

Von J. B. Jack

Nachtrag zu: "Botanische Wanderungen am Bodensee und im Hegau"

Von Jos. Bernh. Jack