O LONG ZOOM: PENSAMENTO SISTÊMICO, INTERDISCIPLINARIDADE E COMUNICAÇÃO EM STEVEN JOHNSON

Steven Johnson é uma referência de relevo na pesquisa brasileira sobre comunicação digital. Ainda assim, essa temática é abordada apenas de maneira tangencial na maior parte da sua produção bibliográfica: os livros de Johnson são, ao mesmo tempo, exemplos e defesas de um método de pesquisa e exposição que integra pensamento sistêmico e abordagem interdisciplinar ao qual ele chama long zoom e que tem a pretensão de trazer novos fatos sobre os fenômenos aos quais é aplicado. Essa dissertação, através de um estudo teórico, analisa os limites e as possibilidades do pensamento de Steven Johnson e de seu long zoom para a pesquisa científica em Comunicação Social. Por meio de uma revisão bibliográfica da obra do autor, cruzando-a com dados biográficos, é apresentada uma análise de conjunto do pensamento de Steven Johnson que o caracteriza como, fundamentalmente, um pensamento epistemológico. A partir disso, com uma breve revisão das principais miradas epistemológicas, da Grécia Antiga ao século XXI, são traçados os parentescos intelectuais do long zoom. Num terceiro momento, revisa-se as formas com que Johnson aplica o long zoom aos problemas da Comunicação Social, verificando-se uma tendência dominante a ressaltar as consequências sociais dos fluxos de informação permitidos pelos meios de comunicação TV e internet, sobretudo, mas também videogames numa aproximação com a Cibernética e, principalmente, um modelo mcluhaniano de análise da comunicação. Após esse trajeto, conclui-se que, a despeito das suas próprias pretensões, Johnson não apresenta novos fatos com o seu long zoom, mas novos pontos de vista e proposições teóricas que podem ou não vir a ser comprovadas pelo trabalho de cientistas.

8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus

8-Hydroxydeoxyguanosine (80HDG) is a specific marker of oxidative damage to DNA. We have observed that patients with SLE (systemic lupus erythematosus), have undetectable levels of urinary 80HDG by HPLC. Further analysis by GC-MS confirmed that levels of 80HDG in SLE urine were 10(3)-fold lower than in an age- and sex-matched control group. Experiments utilising cultures of SLE and normal lymphocytes exposed to H2O2 confirmed the impaired ability of SLE lymphocytes to repair 80HDG. We subsequently observed in SLE patients that 80HDG had accumulated in low molecular weight DNA associated with circulating immune complexes. We suggest that oxygen radicals may induce pathology in SLE by maintaining the presence of an antigenic form of DNA in the circulation.

Lupus prognosis:a clinical study

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Immunoregulatory soluble CTLA-4 modifies effector T cell responses in systemic lupus erythematosus

Acknowledgments This work was supported by Arthritis Research UK (Grant no. 19282). We are grateful to Dr. Nick Fluck for his invaluable support in recruiting patients for the study, and Mrs. Vivien Vaughan for her invaluable expertise in recruiting study participants and maintaining ethical documentation.

Étude des mécanismes thrombotiques chez les patients atteints du lupus érythémateux disséminé : implications des auto-anticorps antilamine B1 et anticellules endothéliales

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

A geographical perspective on the decline and extermination of the Irish wolf Canis lupus - an initial assessment

Wolves were a component of the Irish landscape until 1786 when the last one was killed. It had taken a concerted effort by Cromwell and his Government in Ireland to bring this about particularly through deforestation and landscape change, legislation, bounties and the efforts of a few professional wolf hunters. This paper estimates the wolf population in Ireland at three lime periods in the 1600s and examines how each of the forces already mentioned led to their eventual extermination. The 87 dated and documented wolf incidents which include wolf attacks on both animals and humans, wolf observations and the hunting and killing of wolves over the period 1560-1789 show both spatial and temporal variations.

Étude des mécanismes thrombotiques chez les patients atteints du lupus érythémateux disséminé : implications des auto-anticorps antilamine B1 et anticellules endothéliales

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber

As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics.

Complicações do Alcoolismo na Família: Intervenções de Enfermagem

Desde há muito, o alcoolismo tem sido um tema em voga. No entanto, não deixa de ser um tema atual, objeto de preocupação e discussão de profissionais de diversas áreas do saber. Não obstante as respostas e os contributos que os profissionais trazem à mesa e que muito contribuem para a compreensão do fenómeno “alcoolismo” enquanto problema de Saúde Pública, sabe-se bem que um pouco por todo lado, e Cabo Verde não foge a regra, tem havido um aumento do consumo de álcool e os efeitos nefastos que este acarreta são cada vez mais frequentes e assustadores. Essa problemática é, na sua maioria, abordada sob o ponto de vista do alcoólico, e muito pouco abordada sob a perspetiva da família que tem no seu seio um elemento identificado como alcoólico. Assim com o objetivo de identificar as intervenções de Enfermagem perante as complicações do alcoolismo na família, foi realizado um estudo de caso abordado de forma qualitativa com uma família que tem no seu seio um elemento identificado alcoólico. Os dados foram recolhidas através da observação não estruturada, entrevistas semiestruturadas e questionários. Os resultados demonstram que as complicações do alcoolismo na família giram em torno de perturbações na harmonia e no equilíbrio familiar, violência verbal, problemas financeiros, conflitos interpessoais e sofrimento. Tais complicações demandam intervenção de uma equipa multidisciplinar onde a enfermagem tem um papel proactivo no ensino: processo de doença, no aumento da disponibilidade de aprendizagem, na redução da ansiedade, aumento do sistema de apoio e da autoestima, assistência de autocuidado, motivação do comportamento, facilitação de auto responsabilidade, apoio a tomada de decisão, promoção do envolvimento familiar, suporte a família, apoio ao cuidador, entre outras. As intervenções de enfermagem versadas neste trabalho figuram como ferramentas necessárias no cuidado ao alcoólico e sua família com vista a melhorar a qualidade de vida dos mesmos.

Progressive Multifocal Leukoencephalopathy and Systemic Lupus Erythematosus: Focus on Etiology

Progressive multifocal leukoencephalopathy (PML) caused by reactivation of the JC virus (JCV), a human polyomavirus, occurs in autoimmune disorders, most frequently in systemic lupus erythematosus (SLE). We describe a HIV-negative 34-year-old female with SLE who had been treated with immunosuppressant therapy (IST; steroids and azathioprine) since 2004. In 2011, she developed decreased sensation and weakness of the right hand, followed by vertigo and gait instability. The diagnosis of PML was made on the basis of brain MRI findings (posterior fossa lesions) and JCV isolation from the cerebrospinal fluid (700 copies/ml). IST was immediately discontinued. Cidofovir, mirtazapine, mefloquine and cycles of cytarabine were sequentially added, but there was progressive deterioration with a fatal outcome 1 year after disease onset. This report discusses current therapeutic choices for PML and the importance of early infection screening when SLE patients present with neurological symptoms. In the light of recent reports of PML in SLE patients treated with rituximab or belimumab, we highlight that other IST may just as well be implicated. We conclude that severe lymphopenia was most likely responsible for JCV reactivation in this patient and discuss how effective management of lymphopenia in SLE and PML therapy remains an unmet need.

EULAR Recommendations for Women's Health and the Management of Family Planning, Assisted Reproduction, Pregnancy and Menopause in Patients with Systemic Lupus Erythematosus and/or Antiphospholipid Syndrome

OBJECTIVES: Develop recommendations for women's health issues and family planning in systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). METHODS: Systematic review of evidence followed by modified Delphi method to compile questions, elicit expert opinions and reach consensus. RESULTS: Family planning should be discussed as early as possible after diagnosis. Most women can have successful pregnancies and measures can be taken to reduce the risks of adverse maternal or fetal outcomes. Risk stratification includes disease activity, autoantibody profile, previous vascular and pregnancy morbidity, hypertension and the use of drugs (emphasis on benefits from hydroxychloroquine and antiplatelets/anticoagulants). Hormonal contraception and menopause replacement therapy can be used in patients with stable/inactive disease and low risk of thrombosis. Fertility preservation with gonadotropin-releasing hormone analogues should be considered prior to the use of alkylating agents. Assisted reproduction techniques can be safely used in patients with stable/inactive disease; patients with positive antiphospholipid antibodies/APS should receive anticoagulation and/or low-dose aspirin. Assessment of disease activity, renal function and serological markers is important for diagnosing disease flares and monitoring for obstetrical adverse outcomes. Fetal monitoring includes Doppler ultrasonography and fetal biometry, particularly in the third trimester, to screen for placental insufficiency and small for gestational age fetuses. Screening for gynaecological malignancies is similar to the general population, with increased vigilance for cervical premalignant lesions if exposed to immunosuppressive drugs. Human papillomavirus immunisation can be used in women with stable/inactive disease. CONCLUSIONS: Recommendations for women's health issues in SLE and/or APS were developed using an evidence-based approach followed by expert consensus.

Vaccination of Adult Patients with Systemic Lupus Erythematosus in Portugal

In the wake of the Portuguese vaccination program 50th anniversary it seems appropriate to review vaccination in patients with systemic lupus erythematosus. Controversial issues as regards the association between autoimmune diseases, infections, and vaccines are discussed as well as vaccine safety and efficacy issues as regards chronic immunosuppressant (IS) drug therapy. After a brief overview of national policies, specific recommendations are made as regards vaccination for adult patients with SLE with a particular focus on current IS therapy and unmet needs.