Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases

An additivity-based sequence to reactivity algorithm for the interaction of members of the Kazal family of protein inhibitors with six selected serine proteinases is described. Ten consensus variable contact positions in the inhibitor were identified, and the 19 possible variants at each of these positions were expressed. The free energies of interaction of these variants and the wild type were measured. For an additive system, this data set allows for the calculation of all possible sequences, subject to some restrictions. The algorithm was extensively tested. It is exceptionally fast so that all possible sequences can be predicted. The strongest, the most specific possible, and the least specific inhibitors were designed, and an evolutionary problem was solved.

Letter from James Winthrop to Edward Wigglesworth, 1780 October 4

In this brief letter College Librarian James Winthrop requests that Harvard College Tutor William Bentley be allowed to serve as a deputy librarian.

E. W. Nelson's notes on the Indians of the Yukon and Innoko Rivers, Alaska / edited, with an introd. by James W. VanStone, Curator, North American Archaeology and Ethnology, Field Museum of Natural History.

v.70(1978)

The Nordenskièold collection of Eskimo material culture from Port Clarence, Alaska / James W. VanStone.

n.s. no.14(1990)

Correspondence with James Sullivan, 1789-1792

Includes one bill to James Sullivan for fees incurred by William Sullivan (AB 1792). Also includes receipt for payment.

Power of Attorney, Samuel Shapleigh for James Otis Prentiss, Aug. 18, 1791

Document also contains what appears to be a bill for medical services rendered by Prentiss, a doctor, to William Boman.

Letter from James Otis, Jr. to James Otis, Sr., and portrait print of James Otis Jr., 1743 June 17

Letter from Otis in Boston to his father, James Otis Sr. on June 17, 1743. In the short, half-page letter, Otis asks his father for money to pay for expenses relating to Commencement including the printing of theses, shoes, buckles, and any entertainment. He mentions that he will share entertainment expenses with his classmate Lothrop Russell.

Notes of proceedings and cases determined in the high court of errors and appeals, the court of chancery, and the orphans court of the state of Delaware, 1792-1832

Contains summaries of cases heard by the Delaware Supreme Court and the Delaware Appeals Court in the counties of Sussex, Kent, and Newcastle covering a variety of legal topics. Supposedly based on Wilson's Red Book.

Student notebook of James Blake on Hebrew grammar, 1767

A small paper notebook containing eight-pages of English notes on Hebrew grammar and Hebrew script written by Harvard undergraduate James Blake in 1767. The title of the first page, "Of Nouns," is annotated with the note, "Benj'm Wadsworth, 1767" and the recto of the back cover contains a personal note to "Rev'd Mr. Wadsworth" signed "J. B.," presumably referring to Benjamin Wadsworth (1750-1826; Harvard AB 1769).

[ Bond of James Vansant and Richard Vanhorne], 1753

Bond signed by William Buckley, justice of the peace for Bucks County, Pennsylvania.

Latin exercise book of James Baker, 1759-1760

Small notebook kept by James Baker in the late 1750s; the dates 1755, 1756, and 1758 were written in the book. The volume contains Latin theses, Latin translations from the Book of Genesis, and three pages of English text recording an argument about the soul. The notebook has a string binding and pages of different size. The text does not appear to follow a system of organization and includes scribbles and struck-out words.

Student notebook of James Varney, 1721-1725

The bound notebook contains academic texts copied by Harvard student James Varney in the early 1720s. The texts are written tête-bêche (where both ends of the volume are used to begin writing). The front paste-down endpaper reads 'James Varney his book 1724,' and the rear paste-down endpaper reads 'Joseph Lovett' [AB 1728].