977 resultados para Infeção fúngica invasiva


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Pós-graduação em Engenharia e Ciência de Alimentos - IBILCE

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Pós-graduação em Cirurgia Veterinária - FCAV

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Human fungal infections have increased at an alarming rate in recent years, particularly in immunocompromised individuals. Cryptococcosis is the second most prevalent systemic fungal infection worldwide, and the most prevalent systemic infection in immunocompromised individuals, representing more than 70% of cases. The incidence of cryptococcosis is high in people with HIV/acquired immunodeficiency syndrome (AIDS), with recent estimates indicating that there are one million cases of cryptococcal meningitis globally per year in AIDS patients. The aim of this research was to develop a rapid flow cytometric antifungal susceptibility test and to compare the results with the standard methods. A reference strain and clinical isolates of Cryptococcus neoformans and Cryptococcus gattii were tested for susceptibility to amphotericin B by flow cytometry using propidium iodide as indicator of viability. Flow cytometry (FC) results were compared with the minimum inhibitory concentration (MIC) values determined by microdilution. The antifungal activity of amphotericin B ranged from MICs of 0.06 to 2μg/ml for the 11 isolates studied. The same results were found by FC. The FC method allows same-day results, assisting in the selection of appropriate antifungal therapies. These results demonstrate an excellent correlation between FC and the classic methods of testing for susceptibility to antifungal agents. This rapid diagnosis method makes it possible to quickly administer effective therapeutic interventions, often saving lives.

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Pós-graduação em Bases Gerais da Cirurgia - FMB

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Cancer alters the structure or functions of adjacent organs with their sole presence, and subsequent clinical manifestations, but can also cause harmful effects in distant organs. These clinical changes induced by non-invasive tumor action are of great clinical diversity and are known as paraneoplastic syndromes. This paper describes four cases of canine patients with neurological disorders associated to generalized superficial lymphadenopathy.

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A expansão rápida da maxila cirurgicamente assistida (ERMCA) é realizada por meio de osteotomias nos pilares da maxila e na sutura palatina mediana, promovendo a correção da deficiência transversa da maxila. Técnicas menos invasivas foram descritas, visando à realização desses procedimentos sob anestesia local, eliminando os custos de internação hospitalar e trazendo maior conforto aos pacientes. A proposta deste trabalho foi discutir os aspectos envolvidos na simplificação da técnica da ERMCA sob anestesia local por meio do relato de caso clínico-cirúrgico de paciente com 27 anos de idade. Conclui-se que o diagnóstico por meio da avaliação clínica e dos modelos de estudo é essencial para a indicação da ERMCA e esse procedimento proporciona boa previsibilidade na correção da deficiência transversal, com mínima morbidade. Além disso, a utilização de uma técnica minimamente invasiva é efetiva no tratamento de maxilas atrésicas, com índices de recidiva semelhantes aos das técnicas mais invasivas.

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The oral anticoagulants (AOC) and platelet antiagregants are drugs used for the prevention of thromboembolic phenomena, such as pulmonary embolism in patients with atrial fribrilation heart valves, thrombosis and pulmonary embolism. For patients who are undergoing surgical procedures-dentistry were asked to discontinue the use of anticoagulants until the value of the INR remained = 2.0, that in order to avoid trans and hemorrhages in the postoperative period. However, the AOC can cause the formation of a clot, leading to obstruction of blood pathways. Thus, it became doubtful the medicine for surgery, in which local hemostatic measures would be sufficient to promote hemostasis. Thus, the objective of the review was to evaluate the risk of bleeding in patients AOC users that are subjected to surgical procedures, through a bibliographical survey carried out in relevant clinical studies published between 1990 and 2012, by the MedlinePubMed data. In this review of literature was concluded that the benefit of thromboembolism prevention overcomes the risk hemorrhage, therefore, it is recommended to keep the dose of anticoagulant therapy unchanged for patients undergoing oral surgery and implant dentistry, using appropriate INR levels with the assistance of local hemostatic. In addition, a refined surgical technique should be performed in these patients. With respect to the most invasive oral surgery, with a risk of bleeding, treatment may be necessary in conjunction with the medical staff.

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Pós-graduação em Biociências e Biotecnologia Aplicadas à Farmácia - FCFAR

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)