Lottery Action, February 9-22, 2004, Vol. 11, no. 3

Iowa Lottery Authority Retailer Information Newsletter

Colombes, 21/2/20 [i.e. 22/2/20], équipe [de rugby de l'] Olympique : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58141

Lottery Action, March 22 - April 4, 2004, Vol. 11, no. 6

Iowa Lottery Authority Retailer Information Newsletter

Colombes, 21/2/20 [i.e. 22/2/20], équipe [de rugby du] club athlétique périgourdin : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58140

Lottery Action, April 19-22, 2004, Vol. 11, no. 8

Iowa Lottery Authority Retailer Information Newsletter

22/2/20, [stade de] Saint Cloud, équipe de France [de hockey sur gazon] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58134

22/2/20, [stade de] Saint Cloud, hockey [match de sélection], équipe du reste : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58133

Lottery Action November 3-16, 2003, Vol. 10, no. 22

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, September 22-October 5, 2003, Vol. 10, no. 19

Iowa Lottery Authority Retailer Information Newsletter

22-1-20, arrivée de M. Paul-Boncour [Joseph] à la Chambre [des députés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57726

Basic calcium phosphate crystals induce monocyte/macrophage IL-1(beta) secretion through the NLRP3 inflammasome in vitro.

Basic calcium phosphate (BCP) crystals are associated with severe osteoarthritis and acute periarticular inflammation. Three main forms of BCP crystals have been identified from pathological tissues: octacalcium phosphate, carbonate-substituted apatite, and hydroxyapatite. We investigated the proinflammatory effects of these BCP crystals in vitro with special regard to the involvement of the NLRP3-inflammasome in THP-1 cells, primary human monocytes and macrophages, and mouse bone marrow-derived macrophages (BMDM). THP-1 cells stimulated with BCP crystals produced IL-1β in a dose-dependent manner. Similarly, primary human cells and BMDM from wild-type mice also produced high concentrations of IL-1β after crystal stimulation. THP-1 cells transfected with short hairpin RNA against the components of the NLRP3 inflammasome and mouse BMDM from mice deficient for NLRP3, apoptosis-associated speck-like protein, or caspase-1 did not produce IL-1β after BCP crystal stimulation. BCP crystals induced macrophage apoptosis/necrosis as demonstrated by MTT and flow cytometric analysis. Collectively, these results demonstrate that BCP crystals induce IL-1β secretion through activating the NLRP3 inflammasome. Furthermore, we speculate that IL-1 blockade could be a novel strategy to inhibit BCP-induced inflammation in human disease.

22/12/19, réouverture du musée du Rhin à la maison de Victor Hugo, [6] place des Vosges [à Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57301

22/12/19, réouverture du musée du Rhin à la maison de Victor Hugo [6 place des Vosges à Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57300

La voix de M. Paul Deschanel, Président de la Chambre des députés : discours prononcé le 22 décembre 1914

[Discours. 1914-12-22]