Modelo de negocio de la Cooperativa Multiactiva de Productores de Compostaje y Abonos Orgánicos “COMPOSCOOP” de la ciudad de Manizales

El trabajo de investigación consiste en diseñar un modelo de negocio para la cooperativa “Composcoop” de Manizales, con base en el modelo Canvas, mediante la identificación de los elementos estratégicos que le generan valor al negocio -- La construcción del modelo, como herramienta de planificación estratégica, radicó en reconocer los elementos fundamentales que pueden generar valor al negocio y las actividades que deben tenerse en cuenta en un futuro inmediato para lograr posicionarse en el mercado de los abonos orgánicos -- La investigación tuvo enfoque cualitativo y se llevó a cabo al tener en cuenta cuatro momentos: primero: análisis documental de fuentes secundarias para conocer conceptualizaciones, tipos, importancia y metodología por aplicar; segundo: las entrevistas en profundidad con tres expertos temáticos, para tener mayores argumentos sobre el modelo que habría de trabajarse; tercero: la producción intelectual en un grupo focal para generar discusiones de la empresa, reflexiones de proyección y actividades realizadas para capturar mayor cantidad de clientes y fidelizarlos, y cuarto: hacer una triangulación en relación con los ejercicios antes desarrollados -- Al término del ejercicio se logró identificar la importancia y la pertinencia de la aplicación de un modelo de negocio, desarrollar habilidades que permitiesen potencializar la idea de negocio y definir la importancia de los roles y las responsabilidades frente a la estrategia para desarrollar lo planeado

Lecture by Enrique Martinez Celaya, given at Florida International University, December 5, 2010

Enrique Martinez Celaya talks about his life and his work. Introduction by Carol Damian.

El teatro cómico de Enrique García Álvarez

Enrique García Álvarez (Madrid, 1883-1931) belonged to the group of writers who stood out in the late nineteenth century and early twentieth in what was known as “género chico”, label used to oppose this kind of theater to the dramaturgy considered serious. It was composed of brief and comic works whose intention was to generate a fun time for the spectators. Our author was one of the leading representatives and his numerous creations appeared profusely in the posters of the theaters per hour. In the twentieth century, he adapted to the new forms imposed on the scene. Despite his enormous fame at the time, nowadays Enrique García Álvarez remains completely unknown, not only in the eyes of the general public but also to the more knowledgeable circles of our literature. Studies of his dramatic work are almost nonexistent and basically limited to their collaborations with other authors who had more luck as Arniches or Muñoz Seca. The purpose of this thesis is, therefore, to complete a thorough study of the figure and production of Enrique García Álvarez, as well as its impact on the literature. The opening chapter is a reconstruction of the life and work of the author. In the following chapters, we proceeded to the analysis of structural features such as theme, time, space, and characters of his dramatic world. At the end of these pages, we have included a photographic appendix that illustrates some moments of his personal and professional career. We have also developed appendices to classify his librettos chronologically, by collaborator and by genre...

TRIBUNAL ARBITRAL DE CARLOS EDUARDO NARANJO FLÓREZ Y MANUEL GUILLERMO ESTRADA FLÓREZ VS. EDWIN FERNANDO NUÑEZ SÁNCHEZ

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Validez de contenido de un cuestionario para evaluar las etapas del cambio de comportamiento en estilos de vida en escolares, Colombia: Estudio FUPRECOL

Estudio de validación en escolares pertenecientes a instituciones educativas oficiales de la ciudad de Bogotá, Colombia. Se diseñó y aplicó el CCC-FUPRECOL que indagó por las etapas de cambio para la actividad física/ejercicio, consumo de frutas, verduras, drogas, tabaco e ingesta de bebidas alcohólicas, de manera auto-diligenciada por formulario estructurado.

Estado nutricional y etapas de cambio comportamental frente a la actividad física niños y adolescentes de Bogotá, Colombia: Estudio FUPRECOL

Objetivo: El propósito del estudio fue relacionar la etapa en el cambio en el comportamiento frente a la actividad física y el estado nutricional en escolares entre 9 y 17 años de Bogotá- Colombia, pertenecientes al estudio FUPRECOL. Método: Se trata de un estudio transversal, en 6.606 niños y adolescentes entre 9 y 17 años, pertenecientes a 24 instituciones educativas, de Bogotá-Colombia. Se aplicó de manera auto-diligenciada el cuestionario de cambio de comportamiento en función a la intensión de realizar actividad física (CCC-Fuprecol) y se midió el peso y la estatura para determinar el estado nutricional con el índice de masa corporal (IMC). Resultados: El porcentaje de respuesta fue 94% y se consideraron válidos 6,606 registros, siendo 58.3 % (n=3.850) niñas con un promedio de edad de 12,7±2,3 años. En la población general, el 5,3 % de los escolares se encontraban en etapa de pre-contemplación, 31,8 % en contemplación, el 26,7 % en acción y el 36,2 % en etapa de mantenimiento. Al comparar la etapa de cambio con el estado nutricional por IMC, los escolares clasificados en obesidad mostraron mayor frecuencia de respuesta en la etapa de pre-contemplación, mientras que los escolares con peso saludable acusaron mayores porcentajes en la etapa de mantenimiento. Conclusión: En escolares de Bogotá, Colombia, se encontró una relación estadísticamente significativa entre a la intensión de realizar actividad con el estado nutricional medido con el IMC. Fomentar la promoción de la actividad física y monitorear el estado nutricional, deberá ser una prioridad en las agendas y políticas públicas dentro del ámbito escolar.

The culture of background investigations (Portugal, 1570-1773)

This article seeks to justify why it is possible to speak about a culture of background investigations in Portugal, or even in the Iberian Peninsula, especially in the 17th-18th centuries. It will emphasize three points: the huge number of people who made qualifications in Portugal and in the overseas Empire; how it created specialized knowledge and the need for specialized officers to deal with it; to demonstrate how the culture of qualification conditioned behaviors in different social groups.

El traslado de la capital del Reino de Guatemala (1773-1779). Conflicto de poder y juegos sociales

ResumenSegún los propios términos de los Ministros de la Real Audiencia, la decisión de reconstruir, en un lugar diferente, una nueva capital en la Capitanía General de Guatemala, tras los terremotos de 1773 provocó uno de los mayores asuntos que habrán ocurrido en las Audiencias de América. En este trabajo invitamos al lector a una nueva lectura del acontecimiento tomando en cuenta la complejidad de las apuestas financieras, la personalidad y la psicología de los actores sociales, los conflictos internos a las corporaciones municipales y eclesiásticas la influencia de las redes de poder que irrigaban la sociedad colonial. Una nueva luz en un conflicto del Antiguo Régimen que revela en toda su magnitud las trampas en que suelen caer los hombres de poder y con poca conciencia y de las consecuencias sociales de sus decisiones.AbstractIn their own words, the ministers of the Real Audiencia described the decision to rebuild, in a different location, a new capital for the Captaincy-General of Guatemala, after 1773 earthquakes destroyed the city as one of the greatest events that have occurred in the American Audiencias... In this work, we invite a new reading of this event, taking into account the complexity of the financial stakes, the personality, and psychology of the social actors, the internal conflicts of municipal and ecclesiastic corporations, and the influence of networks of power that reached throughout colonial society. A new light cast over an ancient regime conflict that reveals in all its magnitude the traps that men of power tend to fall into and the limited awareness they have of the social consequences of their decisions.

Environmental monitoring of airborne nanoparticles

The aim of this work was to review the existing instrumental methods to monitor airborne nanoparticle in different types of indoor and outdoor environments in order to detect their presence and to characterise their properties. Firstly the terminology and definitions used in this field are discussed, which is followed by a review of the methods to measure particle physical characteristics including number concentration, size distribution and surface area. An extensive discussion is provided on the direct methods for particle elemental composition measurements, as well as on indirect methods providing information on particle volatility and solubility, and thus in turn on volatile and semivolatile compounds of which the particle is composed. A brief summary of broader considerations related to nanoparticle monitoring in different environments concludes the paper.

Thomas Young's contribution to visual optics : the Bakerian lecture "On the mechanism of the eye"

Thomas Young (1773-1829) carried out major pioneering work in many different subjects. In 1800 he gave the Bakerian Lecture of the Royal Society on the topic of the “mechanism of the eye”: this was published in the following year (Young, 1801). Young used his own design of optometer to measure refraction and accommodation, and discovered his own astigmatism. He considered the different possible origins of accommodation and confirmed that it was due to change in shape of the lens rather than to change in shape of the cornea or an increase in axial length. However, the paper also dealt with many other aspects of visual and ophthalmic optics, such as biometric parameters, peripheral refraction, longitudinal chromatic aberration, depth-of-focus and instrument myopia. These aspects of the paper have previously received little attention. We now give detailed consideration to these and other less-familiar features of Young’s work and conclude that his studies remain relevant to many of the topics which currently engage visual scientists.

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

hSSB1 is a newly discovered single-stranded DNA (ssDNA)-binding protein that is essential for efficient DNA double-strand break signalling through ATM. However, the mechanism by which hSSB1 functions to allow efficient signalling is unknown. Here, we show that hSSB1 is recruited rapidly to sites of double-strand DNA breaks (DSBs) in all interphase cells (G1, S and G2) independently of, CtIP, MDC1 and the MRN complex (Rad50, Mre11, NBS1). However expansion of hSSB1 from the DSB site requires the function of MRN. Strikingly, silencing of hSSB1 prevents foci formation as well as recruitment of MRN to sites of DSBs and leads to a subsequent defect in resection of DSBs as evident by defective RPA and ssDNA generation. Our data suggests that hSSB1 functions upstream of MRN to promote its recruitment at DSBs and is required for efficient resection of DSBs. These findings, together with previous work establish essential roles of hSSB1 in controlling ATM activation and activity, and subsequent DSB resection and homologous recombination (HR).

p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation

p53 is the central member of a critical tumor suppressor pathway in virtually all tumor types, where it is silenced mainly by missense mutations. In melanoma, p53 predominantly remains wild type, thus its role has been neglected. To study the effect of p53 on melanocyte function and melanomagenesis, we crossed the 'high-p53'Mdm4+/- mouse to the well-established TP-ras0/+ murine melanoma progression model. After treatment with the carcinogen dimethylbenzanthracene (DMBA), TP-ras0/+ mice on the Mdm4+/- background developed fewer tumors with a delay in the age of onset of melanomas compared to TP-ras0/+ mice. Furthermore, we observed a dramatic decrease in tumor growth, lack of metastasis with increased survival of TP-ras0/+: Mdm4+/- mice. Thus, p53 effectively prevented the conversion of small benign tumors to malignant and metastatic melanoma. p53 activation in cultured primary melanocyte and melanoma cell lines using Nutlin-3, a specific Mdm2 antagonist, supported these findings. Moreover, global gene expression and network analysis of Nutlin-3-treated primary human melanocytes indicated that cell cycle regulation through the p21WAF1/CIP1 signaling network may be the key anti-melanomagenic activity of p53.