Intra-abdominal fat is related to metabolic syndrome and non-alcoholic fat liver disease in obese youth

Background: Previous studies have shown an association between adiposity, especially intra-abdominal adipose tissue, and hemodynamic/metabolic comorbidities in adults, however it is not clear in pediatric population. The aim of the study was to analyze the relationship between non-alcoholic fatty liver disease (NAFLD) and components of metabolic syndrome (MS) with values of intra-abdominal (IAAT) and subcutaneous (SCAT) adipose tissue in obese children and adolescents.Methods: Cross-sectional study. Subjects: 182 obese sedentary children and adolescents (aged 6 to 16 y), identified by the body mass index (BMI). Measurements: Body composition and trunk fat by dual-energy X-ray absorptiometry- DXA; lipid profile, blood pressure and pubertal stage were also assessed. NAFLD was classified as absent (0), mild (1), moderate (2) and severe (3), and intra-abdominal and subcutaneous abdominal fat thickness were identified by ultrasound. The MS was identified according to the cut offs proposed by World Health Organization adapted for children and adolescents. The chi-square test was used to compare categorical variables, and the binary logistic regression indicated the magnitude of the associations adjusted by potential cofounders (sex, age, maturation, NAFLD and HOMA-IR).Results: Higher quartile of SCAT was associated with elevated blood pressure (p = 0.015), but not associated with NAFLD (p = 0.665). Higher IAAT was positively associated with increased dyslipidemia (p = 0.001), MS (p = 0.013) and NAFLD (p = 0.005). Intermediate (p = 0.007) and highest (p = 0.001) quartile of IAAT were also associated with dyslipidemia, independently of age, sex, maturation, NAFLD and HOMA-IR (homeostatic model assessment-insulin resistance).Conclusion: Obese children and adolescents, with higher IAAT are more prone to develop MS and NAFLD than those with higher values of SCAT, independent of possible confounding variables. © 2013 Silveira et al.; licensee BioMed Central Ltd.

In vivo analgesic activity, toxicity and phytochemical screening of the hydroalcoholic extract from the leaves of Psidium cattleianum Sabine

Ethnopharmacological relevance: Psidium cattleianum Sabine is extensively used in Brazilian traditional medicine to treat several diseases including painful disorders. Aim of the study to investigate the toxicity and the possible analgesic activities of the hydroalcoholic extract from the leaves of Psidium cattleianum Sabine (ELPCS), to support its use in folk medicine. To screen the major phytochemical constituents of this extract and evaluate their antioxidant activity. Materials and methods: ELPCS was assessed for its antioxidant activity using the DPPH model. Its analgesic activity was examined using mouse models of acetic acid-induced writhing and hot plate paw licking models. The major phytochemical constituents of the extract were screened; their toxicity on LLC-MK2 mammalian cells was evaluated. Results: ELPCS exhibited significant peripheral analgesic activity at doses of 60, 80, 100, 200 and 400 mg/kg in mice, but it did not display central analgesic activity and not was toxic to LLC-MK2 cell (LD 50>400 μg/mL). The extract exhibited free radical scavenging activity as evidenced by IC 50 values (15.9 μg/mL) obtained by the DPPH method. Phytochemical screening detected flavonoids, saponins, cardiac glycosides, anthraquinones, and tannins. Conclusions: The results of the experimental studies proved the analgesic activity of ELPCS and supported the traditional use of this plant. © 2013 Elsevier B.V. All rights reserved.

Detecção do gene de peroxidase em sementes de soja pela reação da polimerase em cadeia (PCR)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A capela e o terreiro na chapada: devoção mariana e encantaria de Borba Soeira no quilombo Mimbó, Piauí

Pós-graduação em Ciências Sociais - FFC

Estrutura e ultra-estrutura de membranas biológicas de ovinos da raça santa inês (Ovis aries, L., 1758) a fresco e conservadas em glicerina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

PEC formação universitária: análise e discussão dos novos modelos formativos do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Educación reproductiva y paternidad responsable en Guatemala

Incluye Bibliografía

Gestão dos resíduos sólidos urbanos na microrregião homogênea serra de Botucatu: caracterização física dos resíduos sólidos domésticos na cidade de Botucatu/SP

Pós-graduação em Agronomia (Energia na Agricultura) - FCA

Alunos precoces com indicadores de altas habilidades/superdotação no Ensino Fundamental I: identificação e situações (des)favorecedoras em sala de aula

Pós-graduação em Educação - FFC

Influência do graute e da taxa de armadura no comportamento da alvenaria de blocos de concreto

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Marcadores moleculares associados à qualidade de carne em bovinos Nelore

Pós-graduação em Genética e Melhoramento Animal - FCAV

Impactos no meio físico da bacia hidrográfica do Córrego das Almas, Pouso alegre (MG): subsídios para a educação ambiental

Pós-graduação em Geociências e Meio Ambiente - IGCE

Correlação entre dados geofísicos e geológicos em ocorrência de cobre localizada na bacia sedimentar do Camaquã - RS

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Doses de composto orgânico, com e sem fósforo adicionado ao solo, na produção e qualidade de sementes de alface

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As edições não póstumas de Inocência (1872/1884), de Visconde de Taunay: análise do primeiro capítulo

Pós-graduação em Letras - FCLAS