Liposomal daunorubicin and dexamethasone as a treatment for multiple myeloma - The DD protocol

Context and Objective: Lipasomial daunorubicin has been used to treat hematological malignancies, including multiple myelomo (MM). The goal was to evaluate efficacy, side-effects and toxicity of liposomal daunorubicin and dexamethasone (DD Protocol). Design and Setting: Prospective study of Sírio-Libonês, São Camilo, Brasil and Alemão Oswaldo Cruz hospitals. Methods: Twenty consecutive patients with active MM received four cycles of liposomal daunorubicin intravenously for two hours (25-30 mg/m 2/day) on three consecutive days per month, with oral dexamethasone, (10 mg every six hours) on four consecutive days three times a month. Results: The male/female ratio was 1:1 and median age 60. Nine patients were stage IIA, ten IIIA and one IIIB. The median from diagnosis to starting DD was 13 months. All patients received four cycles, except one. Fifteen had already received chemotherapy before DD. Responses of > 50% reduction in serum monoclonal paraprotein were observed in six patients after first cycle (30%), six after second (30%) and four after third (20%), while four (20%) did not obtain this. Initially, 17 patients (85%) had anemia: 12 (70%) achieved correction. Progressive disease was observed in three patients (15%), while one had minimal response, four (20%) partial and 12 (60%) complete. Hemotologlical toxicity was acceptable: three patients (15%) had neutrophils < 1,000/mm 3; none had thrombocyfopenia. Gastrointestinal toxicity was mild: nausea (10%), anorexio (15%) and no vomiting. Conclusions: This treatment has mild toxicity and good response rate. It may therefore be feasible before autologous bone marraw transplantation.

Os quatro núcleos/eixos de produção da poética de Caio Fernando Abreu

This article presents a short study about the literary work of Brazilian writer Caio Fernando Abreu (1946-1996). In order to study his formal and thematic choices, we established criteria based on concepts like motif and plot (dramatic situation), as developed by Tomachevski (1976). A specific articulation between motives and dramatic situations establishes four nuclei of Abreu's literary production, which is characterized by a literary experimentation with these elements and it constructs an organic work that makes itself and/or is made in a dialogic way (Bakhtin, 1981). Firstly, the main characteristics of the four nuclei and the books that embody them will be presented. Then, we will describe how the motives and dramatic situations are re-elaborated from one nucleus to another. Not only does each nucleus features some new elements, but also contains remainders of previous ones. As such, each of Abreu's works can be considered as both the same and unique.

Fernando Fajnzylber: una visión renovadora del desarrollo en América Latina

Incluye Bibliografía

Escritos de Aníbal Pinto Santa Cruz, 1946-1993: bibliografía existente en la Biblioteca de la CEPAL

Se incluyó además en la investigación la Biblioteca de la Fundación Educacional "Roberto Bellarmino" y la Biblioteca de la Facultad Latinoamericana de Ciencias Sociales (FLACSO)

Escritos de Aníbal Pinto Santa Cruz, 1947-1987: bibliografía existente en la Biblioteca CEPAL

Se incluyó además en la investigación la Biblioteca de la Fundación Educacional "Roberto Bellarmino" y la Biblioteca de la Facultad Latinoamericana de Ciencias Sociales (FLACSO)

ILPES, quinquaginta anni 1962-2012: documentación oficial existente en la Biblioteca Hernán Santa Cruz

Tomos 3 al 4 en proceso de preparación

Hernán Santa Cruz Barceló: un homenaje en la CEPAL

Resumen Este documento es una recopilación de las ponencias hechas por los participantes en el homenaje a don Hernán Santa Cruz Barceló, que tuvo lugar en la sede de la CEPAL en Santiago de Chile el día 7 de mayo de 1999. Fue organizado conjuntamente por el Instituto de Estudios Internacionales de la Universidad de Chile, la Fundación Felipe Herrera y la CEPAL.