I. Calculation of the length of printed lines of all the volumes in the Harvard Library, ca. 1789

This series contains one small leaf with handwritten calculations related to the number of volumes in the Harvard College Library. The verso has the note: "No. of Vol: in Harvard College 11465 vol. making one line 15380 miles long. The document is in the hand of Loammi Baldwin Sr., and may have been created in 1789 while the Library was compiling a catalog of its holdings.

Commonplace book of Hector Orr, 1789-1804

Hector Orr began recording entries in this commonplace book during his first year as a student at Harvard and continued writing in the volume sporadically until 1804. The entries written while he was a student, from 1789 to 1792, include themes written on the following topics: Time, Discontent, Patriotism, Virtue, Conscience, Patience, Avarice, Compassion, Mortality, Self-knowledge, Benevolence, Morning, Anger, Profanity, Bribery, Autumn and Winter, Hermitage, Conscience and Anticipation. He also wrote detailed entries about the forensic disputations in which he and his classmates participated, explaining both the affirmative and negative positions. One of these disputations involved discussion of the Stamp Act, which was then quite recent history. Orr's entries about the disputations list the names of students involved and specify their position in the argument.

Library catalogue notes of Isaac Smith, ca. 1789

Thirteen slips of paper with fragments of handwritten alphabetical lists created by Isaac Smith presumably in his capacity as Harvard Librarian. Most of the entries are surnames or single-word subjects. For example, one slip with "M" entries includes: milway, miracles, miraculous, Mitchell, and Mitchell. Some of the lists have struck-through words or have entries annotated with numbers and the abbreviations "o" and "bk." The verso of one leaf has a brief, undated note regarding the transfer of books between Mr. Hilliard and Mr. Smith.

Letters from Robert Hallowell Gardiner to his brother-in-law, William Tudor,

Four letters written during the Gardiner family’s journey through Maine and while they were settling in at Oaklands.

Letters from Robert Hallowell Gardiner to his brother-in-law, William Tudor,

Four letters in which Gardiner discusses progress of the church he was building on the estate and requests Tudor send him certain books from Boston.

Letters from Robert Hallowell Gardiner to his brother-in-law, William Tudor,

Four letters written from Oaklands. One letter from Emma expressing her grief and shock over the death of their father was finished by her husband, who described hearing the news from a friend, and Emma’s subsequent reaction. In other letters, Gardiner offers advice on resolving the elder William Tudor’s debts by selling off assets such as shares in the Boston Athenaeum and in a pew at Trinity Church. In one letter, Gardiner also offers his opinion regarding the prospects of Henry James (Harry) Tudor’s law career.

Letters from Robert Hallowell Gardiner to his brother-in-law, William Tudor,

Four letters regarding the Gardiner children as well as Delia Stewart’s constantly changing travel plans.

Letters from Robert Hallowell Gardiner to his brother-in-law, William Tudor,

Five letters regarding topics such as Delia Stewart’s travel plans, local Maine politics, and progress in the construction of a church on the estate. In one letter, Gardiner writes about attending the funeral of Bowdoin College President Jesse Appleton.

Letters from Robert Hallowell Gardiner to his brother-in-law, William Tudor,

Four letters regarding topics such as local Maine politics and various household items and books Tudor acquired on the Gardiner family’s behalf.

Letters from Robert Hallowell Gardiner to his brother-in-law, William Tudor,

One letter from Oaklands requesting Tudor come for a visit, and relaying anectdotes about the Gardiner and Stewart children. One letter written to Tudor in Brazil providing an update on family and local politics

Letter from Robert Hallowell Gardinder to his brother-in-law, Frederic Tudor,

Letter written from Gardiner discussing matters of business and briefly mentioning happenings at Oaklands.

Bond, Robert, 2 autographed letters signed to John Winthrop; East Hampton, Conn., 1651 March 8-March 10

Correspondence regarding advice Winthrop had given to Bond's family, and requesting he remit instructions for treating an illness of a neighbor's children.

Letter from George Richards Minot to Daniel Kilham, 1777 December 1

Three-page handwritten letter from Harvard undergraduate George Richards Minot to his friend and Harvard graduate Daniel Kilham, dated December 1, 1777. The letter describes the discipline inflicted upon Minot and seven of his classmates by the Harvard government following a “Thanksgiving frolic,” and the retributions carried out by the students against a Tutor who recommended harsh measures for the accused students. The Early Faculty minutes for 1777 (UAIII 5.5, Volume 4, pages 75-76) describes the students’ crime as “making riotous & tumultuous noises in the Hall…committed in Presence of a number foreigners, & and on a day appointed by Authority for public Thanksgiving.”

Transnational parenting and the well-being of Angolan migrant parents in Europe

Studies on the transnational family highlight the emotional difficulties of migrant parents separated from their children through international migration. This article consists of a large-scale quantitative investigation into the insights of transnational family literature by examining the well-being of transnational parents compared with that of parents who live with their children in the destination country. Furthermore, through a survey of Angolan migrant parents in both the Netherlands and Portugal, we compare the contexts of two receiving country. Our study shows transnational parents are worse off than their non-transnational counterparts in terms of four measures of well-being – health, life satisfaction, happiness, and emotional well-being. Although studies on migrant well-being tend to focus exclusively on the characteristics of the receiving countries, our findings suggest that, to understand migrant parents' well-being, a transnational perspective should also consider the existence of children in the migrant sending country. Finally, comparing the same population in two countries revealed that the receiving country effects the way in which transnational parenting is associated with migrant well-being.

The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite

Parasite proteases play key roles in several fundamental steps of the Plasmodium life cycle, including haemoglobin degradation, host cell invasion and parasite egress. Plasmodium exit from infected host cells appears to be mediated by a class of papain-like cysteine proteases called 'serine repeat antigens' (SERAs). A SERA subfamily, represented by Plasmodium falciparum SERA5, contains an atypical active site serine residue instead of a catalytic cysteine. Members of this SERAser subfamily are abundantly expressed in asexual blood stages, rendering them attractive drug and vaccine targets. In this study, we show by antibody localization and in vivo fluorescent tagging with the red fluorescent protein mCherry that the two P. berghei serine-type family members, PbSERA1 and PbSERA2, display differential expression towards the final stages of merozoite formation. Via targeted gene replacement, we generated single and double gene knockouts of the P. berghei SERAser genes. These loss-of-function lines progressed normally through the parasite life cycle, suggesting a specialized, non-vital role for serine-type SERAs in vivo. Parasites lacking PbSERAser showed increased expression of the cysteine-type PbSERA3. Compensatory mechanisms between distinct SERA subfamilies may thus explain the absence of phenotypical defect in SERAser disruptants, and challenge the suitability to develop potent antimalarial drugs based on specific inhibitors of Plasmodium serine-type SERAs.