From T cell “exhaustion” to anti-cancer immunity

The immune system has the potential to protect from malignant diseases for extended periods of time. Unfortunately, spontaneous immune responses are often inefficient. Significant effort is required to develop reliable, broadly applicable immunotherapies for cancer patients. A major innovation was transplantation with hematopoietic stem cells from genetically distinct donors for patients with hematologic malignancies. In this setting, donor T cells induce long-term remission by keeping cancer cells in check through powerful allogeneic graft-versus-leukemia effects. More recently, a long awaited breakthrough for patients with solid tissue cancers was achieved, by means of therapeutic blockade of T cell inhibitory receptors. In untreated cancer patients, T cells are dysfunctional and remain in a state of T cell "exhaustion". Nonetheless, they often retain a high potential for successful defense against cancer, indicating that many T cells are not entirely and irreversibly exhausted but can be mobilized to become highly functional. Novel antibody therapies that block inhibitory receptors can lead to strong activation of anti-tumor T cells, mediating clinically significant anti-cancer immunity for many years. Here we review these new treatments and the current knowledge on tumor antigen-specific T cells.

Revue des hautes études : ancien Anti-matérialiste : organe mensuel de la synthèse scientifique, sociale et religieuse / dir. René Caillié

Périodicité : Mensuel

Revue des hautes études : ancien Anti-matérialiste : organe mensuel de la synthèse scientifique, sociale et religieuse / dir. René Caillié

1886/09/21 (A1,N1).

Revue des hautes études : ancien Anti-matérialiste : organe mensuel de la synthèse scientifique, sociale et religieuse / dir. René Caillié

1886/11/21 (A1,N3).

Revue des hautes études : ancien Anti-matérialiste : organe mensuel de la synthèse scientifique, sociale et religieuse / dir. René Caillié

1887/01/21 (A2,N5).

Revue des hautes études : ancien Anti-matérialiste : organe mensuel de la synthèse scientifique, sociale et religieuse / dir. René Caillié

1887/02/21 (A2,N6).

Revue des hautes études : ancien Anti-matérialiste : organe mensuel de la synthèse scientifique, sociale et religieuse / dir. René Caillié

1886/10/21 (A1,N2).

Revue des hautes études : ancien Anti-matérialiste : organe mensuel de la synthèse scientifique, sociale et religieuse / dir. René Caillié

1886/12/21 (A1,N4).

Etendard social. Organe de la Jeunesse anti-juive révolutionnaire

1899/06/14 (N3).

Etendard social. Organe de la Jeunesse anti-juive révolutionnaire

1899/05/21 (N1).

Etendard social. Organe de la Jeunesse anti-juive révolutionnaire

1899/06/04 (N2).

Alani Anti-Claudianus.

Bouhier.