Influence of clinicians’ experience and gender on extraction decision in orthodontics

Thesis (Master's)--University of Washington, 2016-06

An X-ray micro-fluorescence study to investigate the distribution of Al, Si, P and Ca ions in the surrounding soft tissue after implantation of a calcium phosphate-mullite ceramic composite in a rabbit animal model

Synthetic calcium phosphates, despite their bioactivity, are brittle. Calcium phosphate-mullite composites have been suggested as potential dental and bone replacement materials which exhibit increased toughness. Aluminium, present in mullite, has however been linked to bone demineralisation and neurotoxicity: it is therefore important to characterise the materials fully in order to understand their in vivo behaviour. The present work reports the compositional mapping of the interfacial region of a calcium phosphate-20 wt% mullite biocomposite/soft tissue interface, obtained from the samples implanted into the long bones of healthy rabbits according to standard protocols (ISO-10993) for up to 12 weeks. X-ray micro-fluorescence was used to map simultaneously the distribution of Al, P, Si and Ca across the ceramic-soft tissue interface. A well defined and sharp interface region was present between the ceramic and the surrounding soft tissue for each time period examined. The concentration of Al in the surrounding tissue was found to fall by two orders of magnitude, to the background level, within similar to 35 mu m of the implanted ceramic.

Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF

Background - The P-glycoprotein (P-gp), an ATP binding cassette transmembrane transporter, is expressed by astrocytes in the adult brain, and is positively modulated during astrogliosis. In a search for factors involved in this modulation, P-gp overexpression was studied in long-term in vitro astroglial cultures. Results - Surprisingly, most factors that are known to induce astroglial activation in astroglial cultures failed to increase P-gp expression. The only effective proteins were IFNγ and those belonging to the IL-6 family of cytokines (IL-6, LIF, CT-1 and CNTF). As well as P-gp expression, the IL-6 type cytokines - but not IFNγ - stimulated the expression of endogenous CNTF in astrocytes. In order to see whether an increased intracellular level of CNTF was necessary for induction of P-gp overexpression by IL-6 type cytokines, by the same cytokines analysis was carried out on astrocytes obtained from CNTF knockout mice. In these conditions, IFNγ produced increased P-gp expression, but no overexpression of P-gp was observed with either IL-6, LIF or CT-1, pointing to a role of CNTF in the intracellular signalling pathway leading to P-gp overexpression. In agreement with this suggestion, application of exogenous CNTF -which is internalised with its receptor - produced an overexpression of P-gp in CNTF-deficient astrocytes. Conclusions - These results reveal two different pathways regulating P-gp expression and activity in reactive astrocytes, one of which depends upon the intracellular concentration of CNTF. This regulation of P-gp may be one of the long searched for physiological roles of CNTF.

The effect of vision congruence on employee empowerment, commitment, satisfaction, and performance

Five models delineating the person-situation fit controversy were developed and tested. Hypotheses were tested to determine the linkages between vision congruence, empowerment, locus of control, job satisfaction, organizational commitment, and employee performance. Vision was defined as a mental image of a possible and desirable future state of the organization.^ Data were collected from 213 employees in a major flower import company. Participants were from various organizational levels and ethnic backgrounds. The data collection procedure consisted of three parts. First, a profile analysis instrument was used which was developed employing a Q-sort based technique, to measure the vision congruence between the CEO and each employee. Second, employees completed a survey instrument which included scales measuring empowerment, locus of control, job satisfaction, organizational commitment, and social desirability. Third, supervisor performance ratings were gathered from employee files. Data analysis consisted of using Kendall's tau to measure the correlation between CEO's and each employee's vision. Path analyses were conducted using the EQS structural equation program to test five theoretical models for goodness-of-fit. Regression analysis was employed to test whether locus of control acted as a moderator variable.^ The results showed that vision congruence is significantly related to job satisfaction and employee commitment, and perceived empowerment acts as an intervening variable affecting employee outcomes. The study also found that people with an internal locus of control were more likely to feel empowered than were those with external beliefs. Implications of these findings for both researchers and practitioners are discussed and suggestions for future research directions are provided. ^

O ciclo indiano de Marguerite Duras à luz da comparação diferencial: a reconfiguração de um personagem

La présente recherche a pour objectif analyser la reconfiguration d'un personnage dans deux romans et dans un texte dramatique de l’écrivaine française Marguerite Duras, qui font partie du Cicle indien. Ils sont : Le Ravissement de Lol V. Stein (1964), Le vice-consul (1965) e India Song (1975). Adoptant la perspective de la Comparaison Différentielle comme approche littéraire, proposée par Ute Heidmann (2008, 2010, 2012), professeur-docteur de l'Université de Lausanne (Suisse), ce travail cherche étudier le personnage Anne-Marie Stretter présent dans ces trois œuvres. On cherche comprendre de quelle manière se produit la réécriture du personnage à partir de trois axes d'analyse : les modalités de l'énonciation, en considérant l'analyse et la comparaison de l'œuvre littéraire comme un événement énonciatif, partant du concept de la scène d'énonciation, proposé par Dominique Maingueneau (2010) ; les modalités d'inscription générique, étroitement liées aux modalités énonciatives, avec un fondement théorique en Todorov (1980) et Heidmann (2012) ; et les modalités de dialogisme intertextuel et interdiscursif, considérant dans la relation dialogique des nouveaux et différentes propositions de sens. Para la compréhension de cela nous partons de Bakhtine (2010), Kristeva (1974), Todorov (1981) et de l'idée de dialogisme et intertextualité, pour arriver à l'idée d'interdiscours proposée par Heidmann (2010, 2012). À partir de cette étude, nous pouvons observer dans l'œuvre d'un même auteur différentes manières de construction d'un personnage, chacun avec ses spécificités et complexités, variant dans le genre et espaces discursifs. L'intérêt de la comparaison différentielle dans cette étude, partant d'un trait commun entre les trois œuvres, est de rendre visible les différences épistémologiques et les nouvelles propositions de sens.

Un modèle complexe de la prise de décisions de soins en fin de vie

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Moniteurs et campeurs : ethnographie d'un camp de vacances spécialisé

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Développement d'un nouveau modèle in vitro du cancer épithélial de l'ovaire

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

HTDE1 : caractérisation, localisation et potentiel transformant d'un membre d'une nouvelle famille de protéines

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Rôle de NF-kappaB dans la progression du cancer de la prostate : études clinicopathologiques et moléculaires

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Profil d'expression moléculaire des tumeurs épithéliales ovariennes à faible et haut potentiel de malignité

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Evaluating conditions for transboundary Marine Spatial Planning: challenges and opportunities on the island of Ireland

Transboundary cooperation is viewed as an essential element of Marine Spatial Planning (MSP). While much of the MSP literature focuses on the need for, and benefits of, transboundary MSP, this paper explores the political and institutional factors that may facilitate the effective transition to such an approach. Drawing on transboundary planning theory and practice, key contextual factors that are likely to expedite the transition to transboundary MSP are reviewed. These include: policy convergence in neighbouring jurisdictions; prior experience of transboundary planning; and good working relations amongst key actors. Based on this review, an assessment of the conditions for transboundary MSP in the adjoining waters of Northern Ireland and the Republic of Ireland is undertaken. A number of recommendations are then advanced for transboundary MSP on the island of Ireland, including, the need to address the role of formal transboundary institutions and the lack of an agreed legal maritime boundary. The paper concludes with some commentary on the political realities of implementing transboundary MSP.

Un modèle complexe de la prise de décisions de soins en fin de vie

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.