Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction

Vertebrate limb induction is triggered in the lateral plate mesoderm (LPM) by a cascade of signaling events originating in the axial mesoderm. While it is known that Fgf, Wnt and retinoic acid (RA) signals are involved in this cascade, their precise regulatory hierarchy has not been determined in any species. tbx5 is the earliest gene expressed in the limb bud mesenchyme. Recently, another transcription factor, Prdm1, has been shown to be crucial for zebrafish forelimb development. Here, we show that Prdm1 is downstream of RA, Wnt2b and Tbx5 activity. We find that RA activity, but not Fgf signaling, is necessary for wnt2b expression. Fgf signaling is required for prdm1 expression in the fin bud, but is not necessary for the initiation of tbx5 expression. We propose a model in which RA signaling from the somitic mesoderm leads to activation of wnt2b expression in the intermediate mesoderm, which then signals to the LPM to trigger tbx5 expression. tbx5 is required for Fgf signaling in the limb bud leading to activation of prdm1 expression, which in turn is required for downstream activation of fgf10 expression.

Strategy-proof choice of acts : a preliminary study

We model social choices as acts mapping states of the world to (social) outcomes. A (social choice) rule assigns an act to every profile of subjective expected utility preferences over acts. A rule is strategy-proof if no agent ever has an incentive to misrepresent her beliefs about the world or her valuation of the outcomes; it is ex-post efficient if the act selected at any given preference profile picks a Pareto-efficient outcome in every state of the world. We show that every two-agent ex-post efficient and strategy-proof rule is a top selection: the chosen act picks the most preferred outcome of some (possibly different) agent in every state of the world. The states in which an agent’s top outcome is selected cannot vary with the reported valuations of the outcomes but may change with the reported beliefs. We give a complete characterization of the ex-post efficient and strategy-proof rules in the two-agent, two-state case, and we identify a rich class of such rules in the two-agent case.

In-bond industry : legal and administrative resolutions /

Mode of access: Internet.

Treaties and other international acts of the United States of America,

Vol. 1 will not appear in final form until all document volumes to which it refers have been published.

Conciliation act, 1896, and Industrial courts act, 1919. Report on conciliation and arbitration including particulars of proceedings under the Conciliation act, 1896, the Coal mines (minimum wage) act, 1912, the Wages (temporary regulation) acts, 1918 and 1919, the Restoration of pre-war practices act, 1919, and the Industrial courts act, 1919 ... 1919[-1920] ...

Title varies slightly.

Phyrne : a drama in four acts and a prologue with an introduction /

Translated and edited by Democritus [i.e. F. A. Laidlaw] from the Italian of Castelvecchio [i. e. G. C. B. L. Pullè] cf. BM, v. 35, col.7; v. 50, col. 931.

School bus safety belts: their use, carryover effects and administrative issues. Final report.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Safety, Washington, D.C.

Administrative careers serving the environment.

Mode of access: Internet.

Power and change : the administrative history of the Office of the Chief of Naval Operations, 1946-1986 /

Mode of access: Internet.

Administrative and review guidelines for the program project grant application.

Mode of access: Internet.

Military and Administrative Activities Working Group report on fiscal training.

Mode of access: Internet.

Peoples Republic of China : administrative atlas /

Supersedes Communist China: administrative atlas, 1969.