Physical activity and strength of the femoral shaft during the adolescent growth spurt

B28A FREE COMMUNICATION/SLIDE BONE DENSITY II

Youth, Religion and Participation : Theoretical and Methodological Approaches

This roundtable session focus on religious and social change as well as democracy and political culture, startingfrom the role of youth in these processes. The role of religion in young people’s participation is a key theme inthe cross-disciplinary network “youth and religion” connected to the Impact program. Participation here includesboth citizens’ “vertical” capacities to make their voices heard and influence decision-makers in the political system(e.g. via elections or civic organizations and social movements) and their “horizontal” capacities to communicateand cooperate with other people (within society at large or certain associations/communities). The participants ofthe session will present influential theories and methodologies used to study participation among youth within theresearch disciplines they represent (i.e. sociology of religion; theology; ethnology; political science). This will befollowed by a joint discussion of how these theories and methodologies have approached religious involvement witha particular focus on youth’s participation in politics, civil society as well as social media and the internet. The aim ofthe session is to look for common themes and new issues that can guide contemporary studies of participation in thefield of youth and religion. The session is open to conference participants interested in the issues discussed.

The effects of optical activity and absorption on two wave mixing in Bi12SiO20

We consider non-degenerate two-wave mixing in photorefractive Bi12SiO20. It is shown theoretically that the presence of absorption and optical activity in the photorefractive media may result in a number of maxima for the gain as the frequency detuning between the two beams is varied. Further, when the beam interaction is used for optical amplification, there may also exist an optimum crystal length beyond which there is a reduction in the useful gain obtainable. Experimental results are presented in confirmation of the theory.

Bromelain's activity and potential as an anti-cancer agent:Current evidence and perspectives

The medicinal qualities of pineapple are recognized in many traditions in South America, China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of proteases. Medicinal qualities of bromelain include anti-inflammatory, anti-thrombotic, fibrinolytic and anti-cancer functions. Existing evidence derived from clinical observations as well as from mouse- and cell-based models suggests that bromelain acts systemically, affecting multiple cellular and molecular targets. In recent years, studies have shown that bromelain has the capacity to modulate key pathways that support malignancy. It is now possible to suggest that the anti-cancer activity of bromelain consists in the direct impact on cancer cells and their micro-environment, as well as in the modulation of immune, inflammatory and haemostatic systems. This review will summarize existing data relevant to bromelain's anti-cancer activity and will suggest mechanisms which account for bromelain's effect, in the light of research involving non-cancer models. The review will also identify specific new research questions that will need to be addressed in order for a full assessment of bromelain-based anti-cancer therapy.

Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

Most of the gemcitabine (dFdC) resistant cell lines manifested high NF?B activity. The NF?B activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NF?B inhibitor, and copper (Cu) on the chemoresistant cell lines was examined. The DS/Cu complex significantly enhanced the cytotoxicity of dFdC (resistant cells: 12.2–1085-fold) and completely reversed the dFdC resistance in the resitant cell lines. The dFdC-induced NF?B activity was markedly inhibited by DS/Cu complex. The data from this study indicated that DS may be used in clinic to improve the therapeutic effect of dFdC in breast and colon cancer patients.