Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9 A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2.

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22

Interleukin-22 (IL-22) plays an important role in the regulation of immune and inflammatory responses in mammals. The IL-22 binding protein (IL-22BP), a soluble receptor that specifically binds IL-22, prevents the IL-22/interleukin-22 receptor 1 (IL-22R1)/interleukin-10 receptor 2 (IL-10R2) complex assembly and blocks IL-22 biological activity. Here we present the crystal structure of the IL-22/IL-22BP complex at 2.75 angstrom resolution. The structure reveals IL-22BP residues critical for IL-22 binding, which were confirmed by site-directed mutagenesis and functional studies. Comparison of IL-22/IL-22BP and IL-22/IL-22R1 crystal structures shows that both receptors display an overlapping IL-22 binding surface, which is consistent with the inhibitory role played by IL-22 binding protein.

Catalog of Paintings Exhibited in the Colby College Art Museum May 8 -22- 1974

This catalog describes paintings by the author, completed as his Senior Scholar Project in art and exhibited in the Colby College Art Museum. Images of the paintings are not available.

Type 22 Design A Starboard Side

print number 67

Type 22 Design A Port Side

print number 71

Type 22 Design B Starboard Side

print number 193 ; Initials Lower Right: ELW (Everett Longley Warner)

Type 22 Design B Port Side

print number 198 ; Initials Lower Right: ELW (Everett Longley Warner)

Type 22 Design C Starboard Side

print number 66

Type 22 Design C Port Side

print number 76

Rastreamento da insuficiência placentária através do Doppler das artérias uterinas por via transvaginal entre 22 e 24 semanas de gestação

Resumo não disponível

Innovation districts: an investigation of the replication of the 22@ Barcelona’s Model in Boston

In 2000, the city of Barcelona launched 22@ Barcelona, dubbed the innovation district. The city sees the project as a means to accelerate Barcelona’s transition toward the knowledge economy. Other cities around the world have since followed the example of Barcelona, building or planning to build their own innovation districts. Boston began to establish its innovation district in 2010. Cities’ ultimate goal for these initiatives is to become more innovative and thus more competitive. Innovative districts are different from technology parks in that they aim to respond to a new economic paradigm in which economic production flows back to cities. The 22@ Barcelona model involves theoretical designs regarding five layers of innovation: economics, urban planning, productive, innovative, and creative. The comparative approach between 22@ Barcelona and Boston’s Innovation District intends to highlight the similarities and differences between those two innovation districts as well as providing a framework to define innovation districts.

Problemas com o Fies são tema de mais de 22 mil postagens nas redes sociais

CORTE DE VERBAS E PROBLEMAS COM FIES MOTIVAM CRÍTICAS NAS REDES O corte de verbas e problemas com o FIES que prejudicaram beneficiários do programa em todo o país foram tema quente nas redes sociais. Nos últimos três dias, foram mais 22 mil menções. As cidades com maior volume de comentários foram Rio de Janeiro, São Paulo, Belém, Belo Horizonte e Brasilia. O mapa mostra também um aumento das menções em capitais do Nordeste, como Recife, João Pessoa e Natal. E a nuvem de palavras mostra a presença de termos como "problemas" e "verbas", relativos às principais reclamações de estudantes e familiares.